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  • The advent of plaque-clearing antibodies to the amyloid-β as the first disease-modifying treatment for Alzheimer’s disease will change the course of this disease, the most common type of dementia. Related progress will gradually alter the trajectory of human aging.

    • Dennis J. Selkoe
  • This Perspective describes and discusses the Information Theory of Aging, which proposes that aging primarily stems from the loss of youthful epigenetic information that can be restored via epigenetic reprogramming to heal injury and reverse aging.

    • Yuancheng Ryan Lu
    • Xiao Tian
    • David A. Sinclair
  • Preclinical models are central to aging research. Yet, these models often lack key features of female humans. Here, the authors discuss shortcomings in the study of female aging and share opportunities for closing the gap in our understanding of sex-dependent aging trajectories.

    • Gabrielle Gilmer
    • Zachary R. Hettinger
    • Fabrisia Ambrosio
  • To build health equity for an aging world, research at the intersections of biology, toxicology and the social and behavioral sciences points the way: to promote healthy aging, focus on the environment.

    • Daniel W. Belsky
    • Andrea A. Baccarelli
  • Cognitive frailty (CF) is the complex and intertwined co-occurrence of physical frailty and cognitive decline. Untangling the interplay between these two domains and correctly diagnosing CF in the clinic is vital for early diagnosis and intervention.

    • Monica M. Nader
    • Caglar Cosarderelioglu
    • Peter M. Abadir
  • High-throughput analysis of cellular landscapes is an important tool to decipher the molecular mechanisms driving aging and disease. Here, Singh and Benayoun discuss key considerations in the design and analysis of omic data to gain robust and reproducible insights into the aging process.

    • Param Priya Singh
    • Bérénice A. Benayoun
  • This Perspective describes the clinical relevance of animal models in dementia for translational research. The authors emphasize incorporating aging as a component in model organisms to understand its contribution to disease pathogenesis.

    • Pranesh Padmanabhan
    • Jürgen Götz
  • In this Perspective, the authors discuss experimental scenarios that breach the assumption of independence of all samples or participants in a study, specifically in aging research. They outline various strategies to improve the rigor and accuracy of the science with design and analysis solutions, while also considering real-world constraints.

    • Daniella E. Chusyd
    • Steven N. Austad
    • David B. Allison
  • In this Perspective, Jan Vijg and Brandon Milholland discuss that at high ages the probability of survival becomes vanishingly small, presenting a soft limit to human lifespan. They elaborate on the mechanistic basis of the observed limit to maximum human lifespan, and on the seemingly impossible future developments required to circumvent the current limit.

    • Brandon Milholland
    • Jan Vijg
  • This Perspective describes the blueprint, challenges and potential solutions for the transformation of Alzheimer’s disease clinical care pathway with biomarker-guided and digitally facilitated detection and intervention at early disease stages.

    • Harald Hampel
    • Rhoda Au
    • Jeffrey Cummings
  • The authors discuss how adopting a complex systems perspective is a crucial step in advancing our understanding of the aging process and requires fundamental alteration of the questions being asked and the methods used to answer them.

    • Alan A. Cohen
    • Luigi Ferrucci
    • Ravi Varadhan
  • Whether and how cognitive training may be used to improve cognitive functions in older age remains incompletely explored, and existing studies have yielded inconsistent results. Here, the authors argue that emerging technologies can transform the field of cognitive enhancement by enabling personalized strategies for cognitive enhancement in older adults.

    • David A. Ziegler
    • Joaquin A. Anguera
    • Adam Gazzaley
  • Suicide is an important problem among older adults and in particular older men. Here, the author discusses factors that impact suicide risk, including social determinants of health and cultural perception of old age, and proposes strategies for a multifaceted approach to suicide prevention.

    • Diego De Leo
  • Age-friendly cities initiatives aim to facilitate active and healthy aging. Focusing on the urban physical environment, the authors argue that longevity-ready cities that aim for better health and well-being for people of all ages from a life-course perspective can accomplish more than initiatives focused solely on old age.

    • Chenghao Wang
    • Diego Sierra Huertas
    • Robert B. Jackson