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The authors found that, across tissues and in multiple datasets, aging is accompanied by a length-associated transcriptome imbalance. In most cases, a decrease in the relative abundance of long transcripts was observed and could be reversed by interventions targeting aging.
The authors analyze microbiome profiles from several public repositories to identify the higher-level indices that best reflect the abundance and ranking of disease-associated and health-associated gut microbes and that may help identify targets for therapeutic modulation.
Transcription factors control cell identity and function in health, disease and aging. Here the authors identify age-associated changes of transcriptional regulatory networks in single cells, revealing cell-type and tissue-type-independent patterns in key pathways, including circadian rhythm, antigen processing, collagen processing and inflammation.
