Cellular and proteomic profiling of aging and COVID-19

  • Laura Arthur
  • Ekaterina Esaulova
  • Maxim N. Artyomov


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    • Arthur et al. leverage different types of big data, either generated in house from cohorts of healthy aging and COVID-19, or downloaded from the ever-increasing public data archives, to disentangle the distinct cellular and proteomic mechanisms of COVID-19 and aging.

      • Ruth R. Montgomery
      • Hanno Steen
      News & Views
    • A phase 2 clinical trial of active immunization against a pathological form of the tau protein provides evidence for feasibility of this approach. Although active treatment did not show benefits on clinical outcome measures, analyses of fluid biomarkers and of a subset of patients with predicted pathology provide hints of efficacy.

      • Douglas Galasko
      News & Views
    • Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ)-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on Aβ toxicity should be revised.

      • Gunnar Brinkmalm
      • Henrik Zetterberg
      News & Views
    • This Perspective discusses the socioeconomic concept of the longevity dividend, in which healthy and productive aging is achieved through a positive correlation between three dimensions: life expectancy, health and the economy.

      • Andrew J. Scott
    • Chronic inflammation, or ‘inflammaging’, is a key process in age-related diseases, and identification of the molecular players involved is a top priority. Cai and Han identified an evolutionary conserved functional lncRNA able to modulate the release of inflammatory SASP molecules from senescent cells through the NF-κB pathway.

      • Rosario Avolio
      • Elias Bechara
      • Gian Gaetano Tartaglia
      News & Views
  • Vaccine hesitancy has created a gap in COVID-19 vaccination status between residents and staff in long-term care settings. Closing that gap is essential to protect our most vulnerable populations and fulfill the duty of care they deserve.

  • The editors speak to Louise Aronson, geriatrician and Pulitzer Prize finalist, about how old age is perceived and defined, and the influence of social determinants on health. Aronson reflects on her experiences caring and advocating for older adults, and outlines some of the challenges to be addressed during the UN Decade of Healthy Aging.

    • Briony Jain
  • The pandemic has highlighted the need for stronger intergenerational connections. Restarting intergenerational programs and expanding newer initiatives to connect people of different ages must be prioritized in debates about how society should progress post-pandemic.

  • There is a major and rapidly growing deficiency in the US eldercare workforce at all levels, especially among physicians. Efforts to increase recruitment and retention into geriatrics have failed, especially among critically important educators and researchers. Possible strategies to assure adequate care for older persons are discussed.

    • John W. Rowe
  • The latest spat over the potential approval of aducanumab, an amyloid-β-targeting drug for Alzheimer’s disease, highlights continuing controversy over the amyloid-β hypothesis.

    • Mark Zipkin
    News Feature