Expression of ErbB4 (Erb-B2 receptor tyrosine kinase 4), a gene associated with major depressive disorder, in dopamine neurons of the ventral tegmental area of mice. The ErbB4-expressing cells are indicated by tdTomato (red) in ErbB4-CreER mice crossed with the Ai9 reporter line, whereas the dopamine neurons are labeled by their expression of TH (tyrosine hydroxylase, green) immunostained with anti-TH. For more information see the article by Wang et al. on pages 1027-1045.

A representative immunofluorescence image showing knockdown of endogenous TDP-43 (upper left, red) from CA1 neurons in adult mouse hippocampus by Adeno-associated virus encoding an shRNA targeting TDP-43. The endogenous levels of TDP-43 were measured from CA1 neurons expressing an shRNA targeting firefly luciferase as a control (lower left, red). GFP was co-expressed with shRNAs and labeled the infected neurons (middle two images, green). Overlaid images of TDP-43 and GFP were shown on the right. For more information see the article by Ni et al. on pages 931-945.

The apoptosis-related orphan nuclear receptor NR4A1 contributes to vulnerability of adult hippocampal neural stem/progenitor cell to FOXG1 dosage. The panel shows murine adult hippocampal neural stem/progenitor cells transduced with a control GFP-expressing retrovirus (left) or a FOXG1-overexpressing retrovirus (right). Cytoplasmic NR4A1 (red) expression is increased after FOXG1 overexpression. DAPI in blue. For more information see the article by Schäffner et al. on pages 497-514.