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Volume 26 Issue 1, January 2021

Volume 26 Issue 1

Single molecule fluorescence in situ hybridization showing Mineralocorticoid Receptor (Nr3c2) expression in mouse hippocampal area CA2. Left: Nr3c2 expression (magenta) in CA1 (top inset) compared with CA2 (bottom inset). Right: Same as left but also including nuclei (blue) and CA2 markers Pcp4 (green) and Acan (red). For more information see the article by Dr. Serena Dudek et al. on pages 350-364.

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  • Comment | | Open Access

    Recent developments in the field of machine learning have spurred high hopes for diagnostic support for psychiatric patients based on brain MRI. But while technical advances are undoubtedly remarkable, the current trajectory of mostly proof-of-concept studies performed on retrospective, often repository-derived data, may not be well suited to yield a substantial impact in clinical practice. Here we review these developments and challenges, arguing for the need of stronger involvement of and input from medical doctors in order to pave the way for machine learning in clinical psychiatry.

    • Dennis M. Hedderich
    •  & Simon B. Eickhoff

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