Volume 26 Issue 12, December 2021

Cover image for Molecular Psychiatry, involving neurons being generated within patient-derived 3D dorsal-forebain organoids. For more information see the article by Notaras et al. on pages 7760-7783.

Image

The distribution pattern of PV⁺ IN subtype in the sensorimotor cortex of Trio^fl/fl and Trio^{fl/fl;Dlx5/6-CIE} mice

Xiaoxuan Sun
Lifang Wang
Jun Li
Image 16 Feb 2022
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News

CSF circulation regulates depression: do not disturb the flow!

Eduardo Loureiro-Campos
Luísa Pinto
Ana Mendanha Falcão
News 20 Oct 2021
Identifying an elusive target with the help of an unproven technique

Mark Weiser
Michael Davidson
News 09 Jul 2021
Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition

Jana Lubec
Predrag Kalaba
Gert Lubec
News 09 Jul 2021

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Correspondence

Can antidepressants unlock prescription of rimonabant in the fight against COVID-19?

Juliette Salles
Fabienne Briand-Mésange
Hugues Chap
Correspondence 19 Jul 2021
Diversity of mechanism of action of psychotropic drugs in their anti-COVID-19 properties

Emmanuel Stip
Danilo Arnone
Syed Fahad Javaid
Correspondence 19 Jul 2021
Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms

Nicolas Hoertel
Marina Sánchez-Rico
Frédéric Limosin
Correspondence 12 Aug 2021
Moving forwards not backwards: heterogeneity in autism spectrum disorders

H. Hobson
S. Petty
Correspondence 16 Jul 2021
The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia

Yifan Li
Shiwu Li
Xiong-Jian Luo
Correspondence 10 Aug 2021

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Comment

A new suspect in the unsolved case of neuroinflammation in schizophrenia

Caitlin E. Murphy
Cynthia Shannon Weickert
Comment 20 Jul 2021

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Article

A genetic basis for friendship? Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice

Abigail J. Smith
Reagan Farmer
Michy P. Kelly
Article 28 Jul 2021
Organizational principles of amygdalar input-output neuronal circuits

Limeng Huang
Yiwen Chen
J. Julius Zhu
Article Open Access 16 Aug 2021
The temporal origin of dentate granule neurons dictates their role in spatial memory

Nuria Masachs
Vanessa Charrier
Djoher Nora Abrous
Article Open Access 15 Sept 2021
Modifying the m⁶A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging

Braulio Martinez De La Cruz
Robert Markus
Helen Miranda Knight
Article Open Access 19 Oct 2021
Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits

António Mateus-Pinheiro
Patrícia Patrício
Luísa Pinto
Article 14 Sept 2021
Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice

Zhongmeng Lai
Weiran Shan
Zhiyi Zuo
Article Open Access 18 Oct 2021
Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility

Clio Korn
Thomas Akam
Mark E. Walton
Article Open Access 30 Jun 2021
Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

Jonathan W. Kanen
Annemieke M. Apergis-Schoute
Trevor W. Robbins
Article Open Access 24 Aug 2021
5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding

Yanlin He
Xing Cai
Yong Xu
Article Open Access 21 Jul 2021
Reversing frontal disinhibition rescues behavioural deficits in models of CACNA1A-associated neurodevelopment disorders

Alexis Lupien-Meilleur
Xiao Jiang
Elsa Rossignol
Article 14 Jun 2021
Pharmacological and optical activation of TrkB in Parvalbumin interneurons regulate intrinsic states to orchestrate cortical plasticity

Frederike Winkel
Maria Ryazantseva
Eero Castrén
Article Open Access 28 Jul 2021
The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats

Cristiane Ribeiro de Carvalho
Mark William Lopes
Roger Walz
Article 27 Jul 2021
Activation of septal OXTr neurons induces anxiety- but not depressive-like behaviors

Tuanjie Huang
Fangxia Guan
Yunlei Yang
Article Open Access 06 Sept 2021
The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis

Thomas Kerloch
Fanny Farrugia
Emilie Pacary
Article Open Access 24 Sept 2021
Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats

Dong-Dong Shi
Ying-Dan Zhang
Zhen Wang
Article 24 Sept 2021
Ependymal cells-CSF flow regulates stress-induced depression

Ji-Seon Seo
Ioannis Mantas
Paul Greengard

Collection:

2021 Highlights from MP
Article Open Access 07 Jul 2021
Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens

Hee-Dae Kim
Jing Wei
Deveroux Ferguson
Article Open Access 12 Jul 2021
Metabolomic changes in animal models of depression: a systematic analysis

Juncai Pu
Yiyun Liu
Peng Xie
Article Open Access 01 Sept 2021
Exploring the genetic heterogeneity in major depression across diagnostic criteria

Bradley S. Jermy
Kylie P. Glanville
Evangelos Vassos
Article Open Access 21 Jul 2021
Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks

Manfred G. Kitzbichler
Athina R. Aruldass
Neil A. Harrison
Article Open Access 17 Sept 2021
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder

Edward J. Goetzl
Owen M. Wolkowitz
Synthia H. Mellon
Article Open Access 01 Sept 2021
Disrupted intrinsic functional brain topology in patients with major depressive disorder

Hong Yang
Xiao Chen
Chao-Gan Yan
Article Open Access 12 Aug 2021
A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression

Helena U. Zacharias
Johannes Hertel
Karl-Heinz Ladwig
Article Open Access 04 Jun 2021
Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming

Mandakh Bekhbat
David R. Goldsmith
Jennifer C. Felger
Article 17 Sept 2021
Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

Yuri Milaneschi
Nils Kappelmann
Golam M. Khandaker
Article Open Access 16 Jun 2021
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

Liubov S. Kalinichenko
Christiane Mühle
Christian P. Müller
Article Open Access 28 Sept 2021
Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response

Saumeh Saeedi
Corina Nagy
Gustavo Turecki
Article 12 Aug 2021
Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors

Vesna Lazarevic
Yunting Yang
Per Svenningsson
Article Open Access 11 Aug 2021
Neurexin 1 variants as risk factors for suicide death

Nancy William
Carsten Reissner
Hilary Coon
Article Open Access 25 Jun 2021
Cerebrospinal fluid proteomics targeted for central nervous system processes in bipolar disorder

Andreas Göteson
Anniella Isgren
Mikael Landén
Article 04 Aug 2021
TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling

Duan Liu
Thanh Thanh Le Nguyen
Richard M. Weinshilboum
Article Open Access 17 Sept 2021
Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD

Lucia Recinella
Annalisa Chiavaroli
Sheila Leone

Collection:

2021 Highlights from MP
Article 30 Jul 2021
Post-traumatic stress symptoms in COVID-19 survivors: a self-report and brain imaging follow-up study

Yiheng Tu
Yuqi Zhang
Li Hu
Article 20 Jul 2021
Reduction of DNMT3a and RORA in the nucleus accumbens plays a causal role in post-traumatic stress disorder-like behavior: reversal by combinatorial epigenetic therapy

Gal Warhaftig
Noa Zifman
Gal Yadid
Article 12 Jul 2021
IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission

Boris Brant
Tchelet Stern
Shani Stern
Article Open Access 17 Sept 2021
Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors

Erica Seigneur
Jie Wang
Thomas C. Südhof

Collection:

2021 Highlights from MP
Article 22 Jun 2021
Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree

Matthew Halvorsen
Jin Szatkiewicz
James J. Crowley
Article 15 Sept 2021
Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model

Matthew R. Bruce
Karen L. Jones
Judy Van de Water
Article Open Access 21 Jul 2021
Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice

Chae-Seok Lim
Min Jung Kim
Bong-Kiun Kaang
Article Open Access 12 Jul 2021
A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain

Shabeesh Balan
Yoshimi Iwayama
Takeo Yoshikawa
Article 15 Jul 2021
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

Jorge Urresti
Pan Zhang
Lilia M. Iakoucheva
Article Open Access 26 Aug 2021

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Correction

Correction: Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

Jorge Urresti
Pan Zhang
Lilia M. Iakoucheva
Correction 21 Sept 2021

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Article

Oxytocin administration in neonates shapes hippocampal circuitry and restores social behavior in a mouse model of autism

Alessandra Bertoni
Fabienne Schaller
Françoise Muscatelli
Article Open Access 21 Jul 2021
Restoring glutamate receptosome dynamics at synapses rescues autism-like deficits in Shank3-deficient mice

Enora Moutin
Sophie Sakkaki
Julie Perroy
Article 30 Jul 2021
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes

V. Zerbi
M. Pagani
N. Wenderoth
Article Open Access 11 Aug 2021
Dysfunction of Trio GEF1 involves in excitatory/inhibitory imbalance and autism-like behaviors through regulation of interneuron migration

Xiaoxuan Sun
Lifang Wang
Jun Li
Article 07 May 2021
Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism

Michael V. Lombardo
Elena Maria Busuoli
Karen Pierce
Article Open Access 02 Aug 2021
Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization

Zhiqiang Sha
Dick Schijven
Clyde Francks
Article Open Access 01 Jul 2021
Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses

Saskia Räuber
Michael Heming
Gerd Meyer zu Hörste
Article Open Access 06 Aug 2021
Altered cortical thickness development in 22q11.2 deletion syndrome and association with psychotic symptoms

Joëlle Bagautdinova
Daniela Zöller
Stephan Eliez
Article Open Access 12 Jul 2021
Thalamic reticular nucleus impairments and abnormal prefrontal control of dopamine system in a developmental model of schizophrenia: prevention by N-acetylcysteine

Xiyu Zhu
Jan-Harry Cabungcal
Anthony A. Grace
Article 30 Jun 2021
In vivo evidence of lower synaptic vesicle density in schizophrenia

Rajiv Radhakrishnan
Patrick D. Skosnik
Deepak C. D’Souza
Article 16 Jun 2021
Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

Xiaojun Wu
Rammohan Shukla
Robert E. McCullumsmith
Article 16 Jul 2021
Grey and white matter microstructure is associated with polygenic risk for schizophrenia

Eva-Maria Stauffer
Richard A. I. Bethlehem
Edward T. Bullmore
Article Open Access 30 Aug 2021
Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis

Zhaowen Liu
Lena Palaniyappan
Jianfeng Feng
Article 28 Jul 2021
Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Dominika Luptáková
Theodosia Vallianatou
Per E. Andrén
Article Open Access 03 Sept 2021
Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis

Justus B. H. Wilke
Martin Hindermann
Hannelore Ehrenreich
Article Open Access 30 Jul 2021
Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids

Michael Notaras
Aiman Lodhi
Dilek Colak
Article Open Access 22 Jun 2021
The GNE-KLH anti-cocaine vaccine protects dams and offspring from cocaine-induced effects during the prenatal and lactating periods

Paulo Sérgio de Almeida Augusto
Raissa Lima Gonçalves Pereira
Frederico Duarte Garcia
Article 11 Aug 2021

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Correction

Correction: The GNE-KLH anti-cocaine vaccine protects dams and offspring from cocaine-induced effects during the prenatal and lactating periods

Paulo Sérgio de Almeida Augusto
Raissa Lima Gonçalves Pereira
Frederico Duarte Garcia
Correction 22 Sept 2021

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Article

Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster

Rita R. Fagan
Patrick J. Kearney
Haley E. Melikian
Article 01 Sept 2021
Angiogenic gene networks are dysregulated in opioid use disorder: evidence from multi-omics and imaging of postmortem human brain

Emily F. Mendez
Haichao Wei
Consuelo Walss-Bass
Article 12 Aug 2021
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults

Elena Rodriguez-Vieitez
Victor Montal
Patrizia Vannini
Article Open Access 29 Sept 2021
Pathfinder: a gamified measure to integrate general cognitive ability into the biological, medical, and behavioural sciences

Margherita Malanchini
Kaili Rimfeld
Robert Plomin
Article Open Access 01 Oct 2021
Mitochondrial dysfunction triggers the pathogenesis of Parkinson’s disease in neuronal C/EBPβ transgenic mice

Eun Hee Ahn
Kecheng Lei
Keqiang Ye
Article 06 Sept 2021

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Correction

Correction: Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain

Diego García-González
Ionut Dumitru
Hannah Monyer
Correction Open Access 07 Jun 2021
Correction: Disruption of NEUROD2 causes a neurodevelopmental syndrome with autistic features via cell-autonomous defects in forebrain glutamatergic neurons

Karen Runge
Rémi Mathieu
Antoine de Chevigny
Correction Open Access 19 Jul 2021
Correction: Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated learning

J. Woo
J. E. Kim
C. J. Lee
Correction 26 Jul 2021
Correction: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders

Nils Opel
Anbupalam Thalamuthu
Udo Dannlowski
Correction Open Access 22 Jun 2021

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Volume 26 Issue 12, December 2021

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