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Immunofluorescent detection of TH+ (green) neurons and phospho-eIF2α (p-eIF2α; red) expression in SNc and VTA DA neurons of eIF2α(S51A/S51A) DAT-Cre and WT DAT-Cre mice, confirming positive targeting of dopaminergic (TH+) neurons for the expression of phospho-mutant eIF2α (scale bars represent 50 µm). Arrows indicate dopaminergic neurons (green) and p-eIF2α (red) co-stain. For more information see the article by Longo et al. on pages 6427-6450.
In addition to neuroinflammatory functions, chemokine CCL5 shows strong neurotrophic properties. In this study, we found that CCL5 facilitates hippocampal glucoregulatory efficiency. CCL5 promotes aerobic glucose metabolism, mitochondrial ATP generation and purine synthesis, improving synaptic plasticity and enhancing memory and cognition functions.