Volume 26 Issue 10, October 2021

Blast-associated tauopathy in humans and rats with neurobehavioral syndromes. Left panel shows a positron emission tomography (PET) scan of the brain of a military veteran with a history of multiple blast exposures imaged with the PET tau ligand [¹⁸F]AV1451 (flortaucipir). Note the cortical ligand retention (red) at the grey/white matter junction, a distribution characteristic of the abnormal tau deposition found in chronic traumatic encephalopathy (CTE). Right panel shows perivascular deposition of hyperphosphorylated tau (green) in an astroglial process from a rat exposed to repetitive low-level blast exposures. Perivascular tau deposition is also a pathological feature of human CTE. For more information see the article by Dickstein et al. on pages 5940-5954.