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Impaired neural connections between the hippocampus and the mPFC in the KCNH2-3.1 transgenic mouse model. Representative Imaris 3D image reconstruction showing the presence of synapses (synapse, red; YFP, green, layer V pyramidal neuron dendrites) in the mPFC of control (upper panel) and KCNH2-3.1 mice (lower panel) at a lower magnification (left) and a higher magnification (right). Decreased synapse number is observed in the VAMP2-FLAG labeled hippocampal CA1 axonal boutons onto mPFC layer V pyramidal neurons of Thy1-YFP-H/NSE/KCNH2-3.1 transgenic mice compare to control mice. For more information, see the article by Ren et al. on pages 206-229.