Volume 23 Issue 10, October 2018

Human iPS cells carrying the APP KM670/671NL heterozygous or homozygous mutation generated by Crispr-cas9 based genome editing (middle or lower panels, respectively) were used to show that SRRM2 and PQBP1 (second and third left panels) are lower in the nuclei and that pSer1068-SRRM2 (fi rst left panels) is increased in the cytoplasm of differentiated neurons. Cytoplasmic levels of TCP1a (right panels) in human iPS cells carrying the APP KM670/671NL mutation and in human normal iPS cell-derived neurons were similar. For more information see the article by Tanaka et al on pages 2090–2110.