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Liver X Receptors regulate cerebrospinal fluid production via maintaining integrity of epithelium lining, epithelial function of choroid plexus and astrocyte function around ventricles. The ventricle system of brain Liver x receptor Double knockout mice showed progressive collapse and eventual closure with age, meanwhile, Aquaporin 4 expression in ependyma and white matter around ventricle was significantly increased (Right up). Aquaporin 4 colocalized with glial fibrillary acidic protein (lower panel). Mouse brian was immunostained for Aquaporin 4 (green), glial fibrillary acidic protein (red) and nuclei was stained with fluorescent dye DAPI (blue). For more info on this topic, please refer to the article by Dai et al on pages 844–856.