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Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors

Molecular Psychiatry volume 23, page 791 (2018)Cite this article

Human iPSC-derived organoids were co-electroporated with GFP and control vector (top) or shRNA targeting MeCP2 (bottom) and examined after 7 days. MeCP2 shRNA-targeted cells comprise an increased number of Pax6(+) neural progenitors. (Scale: 50 μm.) High-magnification of cells is shown in each respective inset (right). The asterisks in the top right panel denote the Pax6(-) cells in the control group. Representative Pax6(+) progenitors seen after depletion of MeCP2 are denoted by arrows in the bottom right panel. (Scale: 20 μm.) For more information on this topic, please refer to the article by Mellios et al. on pages 1051-1065.

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Authors and Affiliations

  1. Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA

    N Mellios, S K Amoah, B A Rodriguez & R Swaminathan

  2. Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA

    N Mellios, D A Feldman, S D Sheridan, J P K Ip, S Kwok, B Rosen, B Crawford, S Chou & M Sur

  3. Departments of Neurology & Psychiatry, Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    S D Sheridan & S J Haggarty

  4. Whitehead Institute for Biomedical Research, Cambridge, MA, USA

    Y Li & R Jaenisch

  5. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    M Ziats

  6. Department of Psychiatry, McGill University, Montreal, QC, Canada

    C Ernst

Authors
  1. N Mellios
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  2. D A Feldman
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  3. S D Sheridan
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  4. J P K Ip
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  5. S Kwok
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  6. S K Amoah
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  7. B Rosen
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  8. B A Rodriguez
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  9. B Crawford
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  10. R Swaminathan
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  11. S Chou
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  12. Y Li
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  13. M Ziats
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  14. C Ernst
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  15. R Jaenisch
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  16. S J Haggarty
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  17. M Sur
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Mellios, N., Feldman, D., Sheridan, S. et al. Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors. Mol Psychiatry 23, 791 (2018). https://doi.org/10.1038/mp.2018.5

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