TABLE OF CONTENTS

Volume 23, Issue 4 (April 2018)

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Image

Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors

N Mellios, D A Feldman, S D Sheridan, J P K Ip, S Kwok, S K Amoah, B Rosen, B A Rodriguez, B Crawford, R Swaminathan, S Chou, Y Li, M Ziats, C Ernst, R Jaenisch, S J Haggarty and M Sur

Mol Psychiatry 23: 791; doi:10.1038/mp.2018.5

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Letters to the Editor

A comparative expression analysis of isocitrate dehydrogenase-3 gene and protein levels in postmortem brain tissues from subjects with bipolar disorder

G Scola, A C Andreazza and L T Young

Mol Psychiatry 23: 792-793; advance online publication, July 25, 2017; doi:10.1038/mp.2017.149

Paternal experience impacts cognitive function in offspring: a pre-existing concept

J Bohacek, U Weber-Stadlbauer and I M Mansuy

Mol Psychiatry 23: 794-795; advance online publication, July 25, 2017; doi:10.1038/mp.2017.162

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Perspective

When should governments increase the supply of psychiatric beds?

S Allison, T Bastiampillai, J Licinio, D A Fuller, N Bidargaddi and S S Sharfstein

Mol Psychiatry 23: 796-800; advance online publication, July 11, 2017; doi:10.1038/mp.2017.139

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Mechanisms of Drug Action

Mechanisms of ketamine action as an antidepressant

P Zanos and T D Gould

Mol Psychiatry 23: 801-811; advance online publication, March 13, 2018; doi:10.1038/mp.2017.255

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Original Articles

Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling

L Cavalleri, E Merlo Pich, M J Millan, C Chiamulera, T Kunath, P F Spano and G Collo

Mol Psychiatry 23: 812-823; advance online publication, November 21, 2017; doi:10.1038/mp.2017.241

Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression

I Esterlis, N DellaGioia, R H Pietrzak, D Matuskey, N Nabulsi, C G Abdallah, J Yang, C Pittenger, G Sanacora, J H Krystal, R V Parsey, R E Carson and C DeLorenzo

Mol Psychiatry 23: 824-832; advance online publication, April 11, 2017; doi:10.1038/mp.2017.58

A novel 5HT3 receptor–IGF1 mechanism distinct from SSRI-induced antidepressant effects

M Kondo, Y Koyama, Y Nakamura and S Shimada

Mol Psychiatry 23: 833-842; advance online publication, April 25, 2017; doi:10.1038/mp.2017.87

A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression

P Riva-Posse, K S Choi, P E Holtzheimer, A L Crowell, S J Garlow, J K Rajendra, C C McIntyre, R E Gross and H S Mayberg

Mol Psychiatry 23: 843-849; advance online publication, April 11, 2017; doi:10.1038/mp.2017.59

Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study

J E Verhoeven, D Révész, M Picard, E E Epel, O M Wolkowitz, K A Matthews, B W J H Penninx and E Puterman

Mol Psychiatry 23: 850-857; advance online publication, March 28, 2017; doi:10.1038/mp.2017.48

Early life adversity and telomere length: a meta-analysis

K K Ridout, M Levandowski, S J Ridout, L Gantz, K Goonan, D Palermo, L H Price and A R Tyrka

Mol Psychiatry 23: 858-871; advance online publication, March 21, 2017; doi:10.1038/mp.2017.26

CK2 regulates 5-HT4 receptor signaling and modulates depressive-like behavior

J Castello, B LeFrancois, M Flajolet, P Greengard, E Friedman and H Rebholz

Mol Psychiatry 23: 872-882; advance online publication, November 21, 2017; doi:10.1038/mp.2017.240

Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors

M Jun, Q Xiaolong, Y Chaojuan, P Ruiyuan, W Shukun, W Junbing, H Li, C Hong, C Jinbo, W Rong, L Yajin, M Lanqun, W Fengchao, W Zhiying, A Jianxiong, W Yun, Z Xia, Z Chen and Y Zengqiang

Mol Psychiatry 23: 883-891; advance online publication, November 28, 2017; doi:10.1038/mp.2017.229

Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress Open

C S Kim, D H Brager and D Johnston

Mol Psychiatry 23: 892-903; advance online publication, April 18, 2017; doi:10.1038/mp.2017.28

Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice

J D Gray, T G Rubin, J F Kogan, J Marrocco, J Weidmann, S Lindkvist, F S Lee, E F Schmidt and B S McEwen

Mol Psychiatry 23: 904-913; advance online publication, December 13, 2016; doi:10.1038/mp.2016.219

Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear

A Asok, A Draper, A F Hoffman, J Schulkin, C R Lupica and J B Rosen

Mol Psychiatry 23: 914-922; advance online publication, April 25, 2017; doi:10.1038/mp.2017.79

Bipolar mood cycles and lunar tidal cycles Open

T A Wehr

Mol Psychiatry 23: 923-931; advance online publication, January 24, 2017; doi:10.1038/mp.2016.263

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group Open

D P Hibar, L T Westlye, N T Doan, N Jahanshad, J W Cheung, C R K Ching, A Versace, A C Bilderbeck, A Uhlmann, B Mwangi, B Krämer, B Overs, C B Hartberg, C Abé, D Dima, D Grotegerd, E Sprooten, E Bøen, E Jimenez, F M Howells, G Delvecchio, H Temmingh, J Starke, J R C Almeida, J M Goikolea, J Houenou, L M Beard, L Rauer, L Abramovic, M Bonnin, M F Ponteduro, M Keil, M M Rive, N Yao, N Yalin, P Najt, P G Rosa, R Redlich, S Trost, S Hagenaars, S C Fears, S Alonso-Lana, T G M van Erp, T Nickson, T M Chaim-Avancini, T B Meier, T Elvsåshagen, U K Haukvik, W H Lee, A H Schene, A J Lloyd, A H Young, A Nugent, A M Dale, A Pfennig, A M McIntosh, B Lafer, B T Baune, C J Ekman, C A Zarate, C E Bearden, C Henry, C Simhandl, C McDonald, C Bourne, D J Stein, D H Wolf, D M Cannon, D C Glahn, D J Veltman, E Pomarol-Clotet, E Vieta, E J Canales-Rodriguez, F G Nery, F L S Duran, G F Busatto, G Roberts, G D Pearlson, G M Goodwin, H Kugel, H C Whalley, H G Ruhe, J C Soares, J M Fullerton, J K Rybakowski, J Savitz, K T Chaim, M Fatjó-Vilas, M G Soeiro-de-Souza, M P Boks, M V Zanetti, M C G Otaduy, M S Schaufelberger, M Alda, M Ingvar, M L Phillips, M J Kempton, M Bauer, M Landén, N S Lawrence, N E M van Haren, N R Horn, N B Freimer, O Gruber, P R Schofield, P B Mitchell, R S Kahn, R Lenroot, R Machado-Vieira, R A Ophoff, S Sarró, S Frangou, T D Satterthwaite, T Hajek, U Dannlowski, U F Malt, V Arolt, W F Gattaz, W C Drevets, X Caseras, I Agartz, P M Thompson and O A Andreassen for the ENIGMA Bipolar Disorder Working Group

Mol Psychiatry 23: 932-942; advance online publication, May 2, 2017; doi:10.1038/mp.2017.73

Early neuromodulation prevents the development of brain and behavioral abnormalities in a rodent model of schizophrenia

R Hadar, L Bikovski, M L Soto-Montenegro, J Schimke, P Maier, S Ewing, M Voget, F Wieske, T Götz, M Desco, C Hamani, J Pascau, I Weiner and C Winter

Mol Psychiatry 23: 943-951; advance online publication, April 4, 2017; doi:10.1038/mp.2017.52

Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment Open

Y Zhou, F Dong, T A Lanz, V Reinhart, M Li, L Liu, J Zou, H S Xi and Y Mao

Mol Psychiatry 23: 952-962; advance online publication, September 19, 2017; doi:10.1038/mp.2017.166

Genetic risk for schizophrenia and psychosis in Alzheimer disease

M A A DeMichele-Sweet, E A Weamer, L Klei, D T Vrana, D J Hollingshead, H J Seltman, R Sims, T Foroud, I Hernandez, S Moreno-Grau, L Tárraga, M Boada, A Ruiz, J Williams, R Mayeux, O L Lopez, E L Sibille, M I Kamboh, B Devlin and R A Sweet

Mol Psychiatry 23: 963-972; advance online publication, May 2, 2017; doi:10.1038/mp.2017.81

Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families

R Harripaul, N Vasli, A Mikhailov, M A Rafiq, K Mittal, C Windpassinger, T I Sheikh, A Noor, H Mahmood, S Downey, M Johnson, K Vleuten, L Bell, M Ilyas, F S Khan, V Khan, M Moradi, M Ayaz, F Naeem, A Heidari, I Ahmed, S Ghadami, Z Agha, S Zeinali, R Qamar, H Mozhdehipanah, P John, A Mir, M Ansar, L French, M Ayub and J B Vincent

Mol Psychiatry 23: 973-984; advance online publication, April 11, 2017; doi:10.1038/mp.2017.60

Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis

S Boku, T Izumi, S Abe, T Takahashi, A Nishi, H Nomaru, Y Naka, G Kang, M Nagashima, A Hishimoto, S Enomoto, G Duran-Torres, K Tanigaki, J Zhang, K Ye, S Kato, P T Männistö, K Kobayashi and N Hiroi

Mol Psychiatry 23: 985-992; advance online publication, August 22, 2017; doi:10.1038/mp.2017.158

ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains

R M Cantor, L Navarro, H Won, R L Walker, J K Lowe and D H Geschwind

Mol Psychiatry 23: 993-1000; advance online publication, May 23, 2017; doi:10.1038/mp.2017.114

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder Open

M V Lombardo, H M Moon, J Su, T D Palmer, E Courchesne and T Pramparo

Mol Psychiatry 23: 1001-1013; advance online publication, March 21, 2017; doi:10.1038/mp.2017.15

A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder

L Yang, S Chang, Q Lu, Y Zhang, Z Wu, X Sun, Q Cao, Y Qian, T Jia, B Xu, Q Duan, Y Li, K Zhang, G Schumann, D Liu, J Wang, Y Wang and L Lu

Mol Psychiatry 23: 1014-1020; advance online publication, April 18, 2017; doi:10.1038/mp.2017.74

Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated learning

J Woo, J E Kim, J J Im, J Lee, H S Jeong, S Park, S-Y Jung, H An, S Yoon, S M Lim, S Lee, J Ma, E Y Shin, Y-E Han, B Kim, E H Lee, L Feng, H Chun, B-E Yoon, I Kang, S R Dager, I K Lyoo and C J Lee

Mol Psychiatry 23: 1021-1030; advance online publication, June 27, 2017; doi:10.1038/mp.2017.113

Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours

A C Ferreira, T Santos, B Sampaio-Marques, A Novais, S D Mesquita, P Ludovico, L Bernardino, M Correia-Neves, N Sousa, J A Palha, J C Sousa and F Marques

Mol Psychiatry 23: 1031-1039; advance online publication, May 9, 2017; doi:10.1038/mp.2017.95

Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex

D Scheggia, E Zamberletti, N Realini, M Mereu, G Contarini, V Ferretti, F Managò, G Margiani, R Brunoro, T Rubino, M A De Luca, D Piomelli, D Parolaro and F Papaleo

Mol Psychiatry 23: 1040-1050; advance online publication, June 20, 2017; doi:10.1038/mp.2017.126

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

N Mellios, D A Feldman, S D Sheridan, J P K Ip, S Kwok, S K Amoah, B Rosen, B A Rodriguez, B Crawford, R Swaminathan, S Chou, Y Li, M Ziats, C Ernst, R Jaenisch, S J Haggarty and M Sur

Mol Psychiatry 23: 1051-1065; advance online publication, April 25, 2017; doi:10.1038/mp.2017.86

Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study

S-M Wei, E B Baller, P D Kohn, J S Kippenhan, B Kolachana, S J Soldin, D R Rubinow, P J Schmidt and K F Berman

Mol Psychiatry 23: 1066-1075; advance online publication, April 18, 2017; doi:10.1038/mp.2017.72

The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders: a delineation of four potential pathways to illness

K S Kendler, H Ohlsson, R S E Keefe, K Sundquist and J Sundquist

Mol Psychiatry 23: 1076-1083; advance online publication, April 18, 2017; doi:10.1038/mp.2017.78

Structural alterations within cerebellar circuitry are associated with general liability for common mental disorders

A L Romer, A R Knodt, R Houts, B D Brigidi, T E Moffitt, A Caspi and A R Hariri

Mol Psychiatry 23: 1084-1090; advance online publication, April 11, 2017; doi:10.1038/mp.2017.57

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Corrigendum

Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors FREE

M Jun, Q Xiaolong, Y Chaojuan, P Ruiyuan, W Shukun, W Junbing, H Li, C Hong, C Jinbo, W Rong, L Yajin, M Lanqun, W Fengchao, W Zhiying, A Jianxiong, W Yun, Z Xia, Z Chen and Y Zengqiang

Mol Psychiatry 23: 1091; advance online publication, January 9, 2018; doi:10.1038/mp.2017.254

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