TABLE OF CONTENTS

Volume 23, Issue 2 (February 2018)

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Synaptic mechanism in Alzheimer’s disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer’s disease

X Yang, C Yao, T Tian, X Li, H Yan, J Wu, H Li, L Pei, D Liu, Q Tian, L-Q Zhu and Y Lu

Mol Psychiatry 23: 167; doi:10.1038/mp.2018.1

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News and Commentary

Polygenic prediction of obsessive compulsive symptoms

N R Zilhão, A Abdellaoui, D J A Smit, D C Cath, J J Hottenga and D I Boomsma

Mol Psychiatry 23: 168-169; advance online publication, December 5, 2017; doi:10.1038/mp.2017.248

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Perspective

Trained innate immunity: a salient factor in the pathogenesis of neuroimmune psychiatric disorders

A P Salam, A Borsini and P A Zunszain

Mol Psychiatry 23: 170-176; advance online publication, December 12, 2017; doi:10.1038/mp.2017.186

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Review

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review Open

K E Hopperton, D Mohammad, M O Trépanier, V Giuliano and R P Bazinet

Mol Psychiatry 23: 177-198; advance online publication, December 12, 2017; doi:10.1038/mp.2017.246

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Original Articles

A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses Open

X Yang, C Yao, T Tian, X Li, H Yan, J Wu, H Li, L Pei, D Liu, Q Tian, L-Q Zhu and Y Lu

Mol Psychiatry 23: 199-210; advance online publication, September 27, 2016; doi:10.1038/mp.2016.151

Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer’s disease therapy

S Moriguchi, T Ishizuka, Y Yabuki, N Shioda, Y Sasaki, H Tagashira, H Yawo, J Z Yeh, H Sakagami, T Narahashi and K Fukunaga

Mol Psychiatry 23: 211-221; advance online publication, October 25, 2016; doi:10.1038/mp.2016.187

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females Open

E E Palmer, T Stuhlmann, S Weinert, E Haan, H Van Esch, M Holvoet, J Boyle, M Leffler, M Raynaud, C Moraine, H van Bokhoven, T Kleefstra, K Kahrizi, H Najmabadi, H-H Ropers, M R Delgado, D Sirsi, S Golla, A Sommer, M P Pietryga, W K Chung, J Wynn, L Rohena, E Bernardo, D Hamlin, B M Faux, D K Grange, L Manwaring, J Tolmie, S Joss, DDD Study, J M Cobben, F A M Duijkers, J M Goehringer, T D Challman, F Hennig, U Fischer, A Grimme, V Suckow, L Musante, J Nicholl, M Shaw, S P Lodh, Z Niu, J A Rosenfeld, P Stankiewicz, T J Jentsch, J Gecz, M Field and V M Kalscheuer

Mol Psychiatry 23: 222-230; advance online publication, August 23, 2016; doi:10.1038/mp.2016.135

Association of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism Open

M Rubinstein, A Patowary, I B Stanaway, E McCord, R R Nesbitt, M Archer, T Scheuer, D Nickerson, W H Raskind, E M Wijsman, R Bernier, W A Catterall and Z Brkanac

Mol Psychiatry 23: 231-239; advance online publication, December 13, 2016; doi:10.1038/mp.2016.222

Gestational vitamin D deficiency and autism-related traits: the Generation R Study Open

A A E Vinkhuyzen, D W Eyles, T H J Burne, L M E Blanken, C J Kruithof, F Verhulst, V W Jaddoe, H Tiemeier and J J McGrath

Mol Psychiatry 23: 240-246; advance online publication, November 29, 2016; doi:10.1038/mp.2016.213

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial Open

R E Frye, J Slattery, L Delhey, B Furgerson, T Strickland, M Tippett, A Sailey, R Wynne, S Rose, S Melnyk, S Jill James, J M Sequeira and E V Quadros

Mol Psychiatry 23: 247-256; advance online publication, October 18, 2016; doi:10.1038/mp.2016.168

The familial co-aggregation of ASD and ADHD: a register-based cohort study Open

L Ghirardi, I Brikell, R Kuja-Halkola, C M Freitag, B Franke, P Asherson, P Lichtenstein and H Larsson

Mol Psychiatry 23: 257-262; advance online publication, February 28, 2017; doi:10.1038/mp.2017.17

ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties Open

B St Pourcain, E B Robinson, V Anttila, B B Sullivan, J Maller, J Golding, D Skuse, S Ring, D M Evans, S Zammit, S E Fisher, B M Neale, R J L Anney, S Ripke, M V Hollegaard, T Werge, iPSYCH-SSI-Broad Autism Group, A Ronald, J Grove, D M Hougaard, A D Børglum, P B Mortensen, M J Daly and G Davey Smith

Mol Psychiatry 23: 263-270; advance online publication, January 3, 2017; doi:10.1038/mp.2016.198

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models Open

J Xu, B J Hartley, P Kurup, A Phillips, A Topol, M Xu, C Ononenyi, E Foscue, S-M Ho, T D Baguley, N Carty, C S Barros, U Müller, S Gupta, P Gochman, J Rapoport, J A Ellman, C Pittenger, B Aronow, A C Nairn, M W Nestor, P J Lombroso and K J Brennand

Mol Psychiatry 23: 271-281; advance online publication, October 18, 2016; doi:10.1038/mp.2016.163

Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits

A Alachkar, L Wang, R Yoshimura, A R Hamzeh, Z Wang, N Sanathara, S M Lee, X Xu, G W Abbott and O Civelli

Mol Psychiatry 23: 282-294; advance online publication, August 15, 2017; doi:10.1038/mp.2017.164

Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor Open

E Scarr, M Udawela, E A Thomas and B Dean

Mol Psychiatry 23: 295-303; advance online publication, November 1, 2016; doi:10.1038/mp.2016.195

The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner

S C Page, G R Hamersky, R A Gallo, M D Rannals, N E Calcaterra, M N Campbell, B Mayfield, A Briley, B N Phan, A E Jaffe and B J Maher

Mol Psychiatry 23: 304-315; advance online publication, March 14, 2017; doi:10.1038/mp.2017.37

Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial

J L Roffman, L J Petruzzi, A S Tanner, H E Brown, H Eryilmaz, N F Ho, M Giegold, N J Silverstein, T Bottiglieri, D S Manoach, J W Smoller, D C Henderson and D C Goff

Mol Psychiatry 23: 316-322; advance online publication, March 14, 2017; doi:10.1038/mp.2017.41

Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia

T Notter, J M Coughlin, T Gschwind, U Weber-Stadlbauer, Y Wang, M Kassiou, A C Vernon, D Benke, M G Pomper, A Sawa and U Meyer

Mol Psychiatry 23: 323-334; advance online publication, January 17, 2017; doi:10.1038/mp.2016.248

Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions Open

N Kappelmann, G Lewis, R Dantzer, P B Jones and G M Khandaker

Mol Psychiatry 23: 335-343; advance online publication, October 18, 2016; doi:10.1038/mp.2016.167

Lipocalin-2 protects the brain during inflammatory conditions Open

S S Kang, Y Ren, C-C Liu, A Kurti, K E Baker, G Bu, Y Asmann and J D Fryer

Mol Psychiatry 23: 344-350; advance online publication, January 10, 2017; doi:10.1038/mp.2016.243

Cafeteria diet and probiotic therapy: cross talk among memory, neuroplasticity, serotonin receptors and gut microbiota in the rat

J E Beilharz, N O Kaakoush, J Maniam and M J Morris

Mol Psychiatry 23: 351-361; advance online publication, March 14, 2017; doi:10.1038/mp.2017.38

JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche Open

H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson, H van Praag and E T Coffey

Mol Psychiatry 23: 362-374; advance online publication, November 15, 2016; doi:10.1038/mp.2016.203

Evidence for neuroplastic compensation in the cerebral cortex of persons with depressive illness

R Bansal, D J Hellerstein and B S Peterson

Mol Psychiatry 23: 375-383; advance online publication, March 7, 2017; doi:10.1038/mp.2017.34

Identification of a novel, fast-acting GABAergic antidepressant

K M J McMurray, M J Ramaker, A M Barkley-Levenson, P S Sidhu, P K Elkin, M K Reddy, M L Guthrie, J M Cook, V H Rawal, L A Arnold, S C Dulawa and A A Palmer

Mol Psychiatry 23: 384-391; advance online publication, March 21, 2017; doi:10.1038/mp.2017.14

Peripheral administration of lactate produces antidepressant-like effects Open

A Carrard, M Elsayed, M Margineanu, B Boury-Jamot, L Fragnière, E M Meylan, J-M Petit, H Fiumelli, P J Magistretti and J-L Martin

Mol Psychiatry 23: 392-399; advance online publication, October 18, 2016; doi:10.1038/mp.2016.179

The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders Open

H Chang, N Hoshina, C Zhang, Y Ma, H Cao, Y Wang, D-d Wu, S E Bergen, M Landén, C M Hultman, M Preisig, Z Kutalik, E Castelao, M Grigoroiu-Serbanescu, A J Forstner, J Strohmaier, J Hecker, T G Schulze, B Müller-Myhsok, A Reif, P B Mitchell, N G Martin, P R Schofield, S Cichon, M M Nöthen, The Swedish Bipolar Study Group, MooDS Bipolar Consortium, H Walter, S Erk, A Heinz, N Amin, C M van Duijn, A Meyer-Lindenberg, H Tost, X Xiao, T Yamamoto, M Rietschel and M Li

Mol Psychiatry 23: 400-412; advance online publication, January 10, 2017; doi:10.1038/mp.2016.231

Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder Open

G Roberts, A Perry, A Lord, A Frankland, V Leung, E Holmes-Preston, F Levy, R K Lenroot, P B Mitchell and M Breakspear

Mol Psychiatry 23: 413-421; advance online publication, December 20, 2016; doi:10.1038/mp.2016.216

A DNA methylation biomarker of alcohol consumption Open

C Liu, R E Marioni, Å K Hedman, L Pfeiffer, P-C Tsai, L M Reynolds, A C Just, Q Duan, C G Boer, T Tanaka, C E Elks, S Aslibekyan, J A Brody, B Kühnel, C Herder, L M Almli, D Zhi, Y Wang, T Huan, C Yao, M M Mendelson, R Joehanes, L Liang, S-A Love, W Guan, S Shah, A F McRae, A Kretschmer, H Prokisch, K Strauch, A Peters, P M Visscher, N R Wray, X Guo, K L Wiggins, A K Smith, E B Binder, K J Ressler, M R Irvin, D M Absher, D Hernandez, L Ferrucci, S Bandinelli, K Lohman, J Ding, L Trevisi, S Gustafsson, J H Sandling, L Stolk, A G Uitterlinden, I Yet, J E Castillo-Fernandez, T D Spector, J D Schwartz, P Vokonas, L Lind, Y Li, M Fornage, D K Arnett, N J Wareham, N Sotoodehnia, K K Ong, J B J van Meurs, K N Conneely, A A Baccarelli, I J Deary, J T Bell, K E North, Y Liu, M Waldenberger, S J London, E Ingelsson and D Levy

Mol Psychiatry 23: 422-433; advance online publication, November 15, 2016; doi:10.1038/mp.2016.192

In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens Open

R M Bastle, R J Oliver, A S Gardiner, N S Pentkowski, F Bolognani, A M Allan, T Chaudhury, M St. Peter, N Galles, C Smith, J L Neisewander and N I Perrone-Bizzozero

Mol Psychiatry 23: 434-443; advance online publication, January 3, 2017; doi:10.1038/mp.2016.238

OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency Open

M Ullrich, M Weber, A M Post, S Popp, J Grein, M Zechner, H Guerrero González, A Kreis, A G Schmitt, N Üçeyler, K-P Lesch and K Schuh

Mol Psychiatry 23: 444-458; advance online publication, January 10, 2017; doi:10.1038/mp.2016.232

Brain structural and functional signatures of impulsive–compulsive behaviours in Parkinson’s disease

F Imperiale, F Agosta, E Canu, V Markovic, A Inuggi, M Jecmenica-Lukic, A Tomic, M Copetti, S Basaia, V S Kostic and M Filippi

Mol Psychiatry 23: 459-466; advance online publication, March 7, 2017; doi:10.1038/mp.2017.18

DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

P-M Martin, R E Stanley, A P Ross, A E Freitas, C E Moyer, A C Brumback, J Iafrati, K S Stapornwongkul, S Dominguez, S Kivimäe, K A Mulligan, M Pirooznia, W R McCombie, J B Potash, P P Zandi, S M Purcell, S J Sanders, Y Zuo, V S Sohal and B N R Cheyette

Mol Psychiatry 23: 467-475; advance online publication, October 18, 2016; doi:10.1038/mp.2016.184

OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals Open

H Ehrenreich, M Mitjans, S Van der Auwera, T P Centeno, M Begemann, H J Grabe, S Bonn and K-A Nave

Mol Psychiatry 23: 476-486; advance online publication, December 6, 2016; doi:10.1038/mp.2016.208

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Corrigendum

JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche Open

H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson, H van Praag and E T Coffey

Mol Psychiatry 23: 487; advance online publication, February 14, 2017; doi:10.1038/mp.2017.21

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Erratum

Peripheral administration of lactate produces antidepressant-like effects Open

A Carrard, M Elsayed, M Margineanu, B Boury-Jamot, L Fragnière, E M Meylan, J-M Petit, H Fiumelli, P J Magistretti and J-L Martin

Mol Psychiatry 23: 488; advance online publication, December 6, 2016; doi:10.1038/mp.2016.237

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