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Current models of human fear learning processes emphasize a primary contribution of the ventromedial prefrontal cortex (vmPFC) to fear inhibition (i.e., fear extinction). Here, we discuss crucial findings from recent brain imaging studies that highlight the role of vmPFC and its subregions in how fear is acquired (i.e., fear conditioning).
A three-dimensional graphic design representation of the potential role of meningeal vessels in Alzheimer disease. Although there are major differences between APOE4(+) and APOE4(−) Alzheimer disease cases (described in detail in the Comment article by Mentis and colleagues), the figure depicts the clearance of macromolecules and other solutes from meningeal lymphatic vessels. Cover image: Ella Maru Studio.
Recent developments in the field of machine learning have spurred high hopes for diagnostic support for psychiatric patients based on brain MRI. But while technical advances are undoubtedly remarkable, the current trajectory of mostly proof-of-concept studies performed on retrospective, often repository-derived data, may not be well suited to yield a substantial impact in clinical practice. Here we review these developments and challenges, arguing for the need of stronger involvement of and input from medical doctors in order to pave the way for machine learning in clinical psychiatry.
