About the Editors
Brian Kelsall, Bethesda, MD, USA
Brian Kelsall received his B.A. in human biology from Stanford University and his M.D. from Case Western Reserve University School of Medicine. After completing residency training in internal medicine at The New York Hospital-Cornell Medical Center and a fellowship in infectious diseases at the University of Virginia Medical Center he went to the NIH, where he completed post-doctoral training with Warren Strober, and where he is now a Senior Investigator and Chief of the Mucosal Immunology Section of the Laboratory of Molecular Immunology in the NIAID. Dr. Kelsall’s interests in mucosal immunology date back to medical school when he studied beliefs and behaviors of cholera patients in Jakarta, Indonesia. This interest was further developed during his time as an infectious disease fellow studying IgA responses to infection with Entamoeba histolytica . At the NIH his primary research interests involve basic mechanisms of immune regulation in the intestine, with a focus on dendritic cell and macrophage function in intestinal viral infections and inflammatory bowel disease. Dr. Kelsall has been a member of the Society for Mucosal Immunology (SMI) since 1995, the Editor-in-chief of Mucosal Immunology since 2008, and current serves as an ad-hoc member of the SMI governing board.
William Agace, Lund, Sweden
William Agace received a B.Sc. (Hons) in 1989 from Bristol University, UK, and a Ph.D. in Mucosal Immunology from Lund University, Sweden in 1996. Following a postdoctoral period in the Department of Rheumatology, Immunology and Allergy, at the Brigham and Women's Hospital, MA (1996-1999), he joined the Immunology Section at Lund University, Sweden, where he has been Section Head since 2005. His research activities focus on immune regulation in the gastrointestinal tract with specific interests in mucosal dendritic and stromal cell subsets and mucosal T cell activation, differentiation and homing. His research has resulted in several Nordic awards including the Anders Jahre Young Researcher Award in Biomedicine from the University of Oslo and the Göran Gustafsson Prize in Medicine from the Swedish Royal Academy of Sciences.
Nadine Cerf-Bensussan, Paris, France
Nadine Cerf-Bensussan is Research Director at INSERM (Institut National de la Santéet de la Recherche) and Head of the INSERM laboratory Interactions of the Intestinal Epithelium with the Immune System in the IMAGINE Institute at UniversitéParis Descartes. Her work is at the intersection of basic and translational research and concerns the mechanisms that control intestinal T cell homeostasis in health and disease. Her major contributions include the first description of CD103, the description of T cell lymphomagenesis from intraepithelial lymphocytes in celiac disease, the dissection of the role of IL-15 is in acute or chronic intestinal inflammation, the demonstration of the role of Segmented Filamentous Bacterium as a driver of the post-natal maturation of gut T cell responses in mice. Dr. Cerf-Bensussan's ongoing work concerns the analysis of early onset inflammatory bowel diseases in children. She was awarded Prize Charles Debray in Gastroenterology, Prize Rosa Lamarca in Clinical Research and she is the recent recipient of an ERC Advanced Grant.
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Kathryn Knoop, St. Louis, MO, USA
Kathryn Knoop received her B.S. in biochemistry from Drake University and Ph.D. in Immunology from Emory University. As a graduate student, Dr. Knoop studied the development of microfold cells (M cells) an intestinal epithelial cell important for the delivery of antigens to Peyer’s patches, with Dr. Ifor Williams. She then moved to Washington University in St Louis for post-doctoral training, with Dr. Rodney Newberry where she continued studying the antigen delivery function of intestinal epithelial cells. She is currently an Instructor of Gastroenterology at the WUSTL School of Medicine and is interested in the ability of goblet cells to deliver luminal antigens across the epithelium, how this process is regulated and its impact on the initiation and maintenance of mucosal immune responses. Dr. Knoop has been a member of the Society for Mucosal Immunology (SMI) since 2009 when she joined as a graduate student.
After earning his Ph.D. in Geography from Loughborough University in the UK, Jason Roberts began work in the subscription services department at Blackwell Science in Oxford, UK. Following a move to Blackwell's US office, he joined that company's editorial team and eventually rose to Senior Editor of US-based medical journals. In 2004 he left Blackwell to become a Managing Editor. After receiving several requests to help out struggling editorial offices, he started Origin Editorial along with Kristen Overstreet, in order to provide peer review operational support and consultancies on peer review management best practice. Dr. Roberts is a past-president of the International Society of Managing and Technical Editors, the pre-eminent group seeking to advance professionalism within editorial offices. Dr. Roberts frequently serves as an invited speaker on such topics as publication ethics, peer review management and editorial office best practices. He is also an active supporter of using guidelines such as CONSORT for Randomized Controlled Trials to strengthen reporting standards in biomedical journals, believing that a smartly-run editorial office can deliver improvements to the quality of peer review and not just perform a purely operational role.
Denise Gibson joined Mucosal Immunology as Managing Editor in October 2012. She has over 15 years experience as a publishing services professional. Denise spent 13 years as a Production Editor at Springer Science + Business Media and has a background in journal project management and author and vendor relations. Most recently she has been with Origin Editorial where she gained experience as managing editor of a health science journal. She lives in the Boston, MA area with her husband and two children.
Dr. Artis is the Michael Kors Professor of Immunology and Director of the Jill Roberts Institute for IBD Research at Weill Cornell Medicine, Cornell University in New York City. He has developed a research program focused on dissecting the pathways that regulate innate and adaptive immune cell function at barrier surfaces in the context of health and disease.
Ken Beagley is Professor of Immunology at the Institute of Health and Biomedical Innovation, Queensland University of Technology and has worked in mucosal immunology for over 25 years. Current research interests focus on immunity to Chlamydia, to define and differentiate the mechanisms of immune-mediated pathology from the immune mechanisms that protect against infection, and to use this information to develop effective chlamydial vaccines. This work involves the use of both mouse and guinea pig models of infection and has now been extended to include development of a chlamydial vaccine for the koala. In all of these studies novel needle-free mucosal vaccination routes (intranasal, sublingual, transcutaneous) are used to target immunity to the female and male reproductive tracts. Other interests include the effects of chlamydial infections on spermatogenesis, ovarian function and the development of reactive arthritis, the development of novel topical microbicide/spermicide dual action therapeutics and development of orally delivered vaccines for genital herpes.
Dr. Brenchley, PhD, received a master's degree from Idaho State University in 1999 and received a Ph.D. in immunology from the University of Texas Southwestern Medical Center at Dallas in 2003. He joined the National Institutes of Health as a research fellow, studying immunopathogenesis and mucosal immunology in HIV-infected individuals. In 2008, he became an investigator in the Laboratory of Molecular Microbiology and was tenured to a senior investigator in 2012. His research interests aim to understand immunological mechanisms of HIV/SIV disease progression. In particular, his research aims to understand how immunological damage within the GI tract of HIV/SIV-infected individuals lead to translocation of microbial products into circulation where they stimulate the immune system and exacerbate disease progression.
Rachel R. Caspi
Dr. Caspi is is a tenured senior investigator, Section Head and Deputy Chief of the Laboratory of Immunology, National Eye Institute, NIH. She also holds an Adjunct Professorship at the University of Pennsylvannia Sch. Med. Dr. Caspi's research centers on responses to immunologically privileged retinal antigens in animal models of autoimmune uveitis, a potentially blinding human disease. Her studies have elucidated many basic mechanisms and helped devise clinically relevant immunotherapeutic approaches. She is the recipient of the 2010 Friedenwald award and the 2012 Alcon Research Institute award and has authored and co-authored over 220 publications.
Andrea Cerutti, MD, PhD, is a Professor of Medicine at Icahn School of Medicine at Mount Sinai. His group explores the cellular and signaling networks underlying class switching and antibody production in B cells. While intestinal immunity requires B cell production of massive amounts of IgA and some IgM, respiratory immunity further implicates B cell production of IgG and IgD. The latter is an enigmatic antibody class released by human B cells lodged in the aero-digestive mucosa, including nasopharyngeal cavities. Dr. Cerutti studies how signals from epithelial cells, goblet cells, dendritic cells, macrophages, granulocytes and innate lymphoid cells of the innate immune system integrate complementary signals from T cells of the adaptive immune system to generate mucosal and systemic humoral responses.
Andrea Cooper is Professor of Cellular Immunology at the University of Leicester (UK) where she pursues the study of mouse and human immune responses to tuberculosis. She obtained her PhD from The London School of Hygiene and Tropical Medicine and pursued her first post-doctoral research at the National Institutes of Health (US). Her early work focused on the immunobiology of leishmaniasis. She continued her investigation of host pathogen interactions at Colorado State University (US) and then at the Trudeau Institute (US) where she studied the factors impacting protective immunity to Mycobacterium tuberculosis. Her underlying interests include - the role of early innate events in driving coordinated immune responses; the role of cytokines and chemokines in initiation, expression and regulation of immunity; the role of lymphocyte priming, differentiation and migratory capacity on prolonged expression of immunity and the role of the inflamed environment in regulating the expression of immunity.
James Di Santo
James Di Santo received his Ph.D. and M.D. from Cornell University Medical College and the Memorial Sloan-Kettering Cancer Center in 1989 and 1991, respectively. He pursued post-doctoral training with Pr. Alain Fischer in Paris, where he identified and characterized genes responsible for primary human immunodeficiency syndromes. In 1994, Dr. Di Santo became a permanent staff scientist with the Institut National de la Santéet de la Recherche Médicale (Inserm). After spending one year as an EMBO Visiting Scientist at the University of Genetics in Cologne Germany with Pr. Klaus Rajewsky, Dr. Di Santo returned to Paris in 1996 and created his own research group studying the cytokine control of lymphocyte development and homeostasis. In 1999, Dr. Di Santo moved his laboratory to the Immunology Department of the Institut Pasteur, where he subsequently directed the Immunology Department from 2002 to 2006. In 2007, Dr. Di Santo was promoted to full Professor at the Institut Pasteur. His current research interests include deciphering the developmental pathways that generate a new family of innate lymphoid cells and developing new"humanized"mouse models as translational tools to understand human disease pathophysiology.
Dr. Dong is currently the Executive Dean of School of Medicine, Tsinghua University, and the Director of the Institute for Immunology at Tsinghua University. Dr. Dong's research is to understand the molecular mechanisms whereby immune and inflammatory responses are normally regulated, and to apply this knowledge to the understanding and treatment of autoimmunity and allergy disorders, as well as cancer. The work from Dr. Dong's group has led to the discoveries of Th17 and T follicular helper (Tfh) cell subsets in the immune system and elucidation of their biological and pathological functions. Dr. Dong has over 180 publications and the honors he has received include the 2009 American Association of Immunologists BD Bioscience Investigator Award and election of fellow, the American Association for the advancement of Science in 2011. In 2014 and 2015 Professor Dong was noted as a Highly Cited Researcher by Thomson Reuters.
Daniel Douek studied medicine at the Universities of Oxford and London. He then practiced internal medicine, before pursuing a Ph.D. in Immunology at the University of London. Dr. Douek was appointed to the NIH Vaccine Research Center in November 2000. His laboratory, the Human Immunology Section, studies the processes that determine the course of human diseases in which the immune system, particularly its T cell arm, plays a central role in their pathogenesis and outcome. He aims to use the knowledge gained to initiate clinical studies of new therapeutic and vaccine approaches. Dr. Douek is a widely published author in the field of human immunology and currently the main focus of his lab is both the pathogenesis and immune control of HIV infection. In 2007 Dr. Douek was given the World AIDS Day Award and was named as one of the 2012 POZ 100 for his significant contributions to accelerating the end of AIDS.
Gerard Eberl earned his Ph.D. in Immunology from the University of Lausanne in Switzerland and went on to serve in postdoctoral fellowships at the Ludwig Institute for Cancer Research in Switzerland and the Skirball Institute in New York. Since 2009, he has served as the head of the Lymphoid Tissue Development Unit at the Institut Pasteur in Paris. He is a founding board member of the Swiss Pasteur Foundation.
Richard Enelow is a Professor of Medicine and Microbiology/Immunology at Geisel School of Medicine at Dartmouth. His area of research broadly concerns the mechanisms that underlie the immune-mediated damage to the lungs which occurs in the context of respiratory virus infection. His clinical interests include immune-mediated lung disease, particularly the idiopathic interstitial pneumonias, and he is exploring the potential relationship between antiviral T cell responses to respiratory infection and chronic inflammatory lung disease. His current work involves understanding viral immunopathogenesis in murine models of influenza infection with particular respect to the mechanisms of tissue injury which occurs in the context of immune-mediated virus clearance.
John V. Forrester
John Forrester is a native Glaswegian, qualifying from his home University of Glasgow, MBChB in 1970 and MD 1979. He was appointed NHS Consultant Ophthalmologist in 1979 in Glasgow and subsequently to the Cockburn Chair of Ophthalmology, University of Aberdeen in 1984. In 2012, he was appointed Professor in Ocular Immunology at The University of Western Australia with joint appointment to the Lions Eye Institute's Division of Immunology. In 2013, he was appointed Honorary Professor at the University of Edinburgh. John Forrester can be described as a self-made clinician-scientist, and in this role was a Founding Member of the Academy of Medical Sciences in the UK. Among his continuing research interests are in the role of infection in autoimmune disease with special reference to ocular inflammatory disease (uveitis) and diabetes, as well as more basic and developmental biological studies of ocular tissues.
Ivan Fuss is a Staff Clinician in the Mucosal immunity Section at the National Institutes of Health. His research interests include the analysis of cytokine pathway abnormalities and their relationship to the occurrence of intestinal inflammation in experimental models and their human counterpart, inflammatory bowel disease. These studies have allowed new approaches to the understanding and treatment of such diseases which led to innovative therapeutic avenues such as the use of Anti-Interleukin-12 in Crohn's disease. He is an active member of the Crohn's and Colitis Foundation and has served on the CCFA Grant Review, Pediatric Affairs Committee and Research Initiatives Council member. Dr. Fuss is a two-time recipient of the NIH Merit Award for his work in the field of IBD and has received the North American Pediatric Gastroenterology Society Young Investigator and the World Congress of Gastroenterology Young Clinician Award.
Dr. Gause received his Ph.D. from Cornell University, was a fellow at the National Institutes of Health, and was a faculty member at the Uniformed Services University (USU) from 1989-2004. In 2004, Dr. Gause joined New Jersey Medical School as the Senior Associate Dean for Research. In 2016 he became director of the Rutgers Biomedical Health Sciences Institute for Infectious and Inflammatory Diseases. Dr. Gause has published over 100 papers, many in high-profile journals, served on editorial boards, organized and chaired symposia, and received a number of awards. His research has recently focused on macrophages and their role in inflammation and resistance.
Richard Grencis holds a Chair in Immunology in the Faculty of Life Sciences at the University of Manchester. After graduating as a zoologist from the University of Nottingham, Richard gained his Ph.D. at the University of Glasgow. His research has focused on the immune response to gastrointestinal helminth infections, particularly nematodes. His work has explored the immunoregulatory mechanisms governing resistance and susceptibility to this group of pathogens. He has also defined novel effector mechanisms and key cytokines responsible for expelling parasites from the intestine. His recent work has concentrated on defining immune mechanisms underpinning chronic infection by gut dwelling nematodes, which is the norm under conditions of natural infection. In addition, he is interested in the interplay between the parasite and the gut epithelium, immune-mediated control of the secreted mucosal barrier — mucus, and the interplay of these components with the host intestinal microflora.
Professor Hansbro is chair in immunology and microbiology and an NHMRC Principal Research Fellow at the Hunter Medical Research Institute and University of Newcastle, Australia. He is Associate Director of the Priority Research Centre for Lung Health there. He has established research programs in COPD, asthma and infection. His group has developed several novel mouse models of the important diseases (COPD, severe, steroid-insensitive asthma, early life infection & lung cancer). He has interrogated them (immune, histological, pathological, lung function & molecular analysis) to further our understanding of pathogenesis and develop novel therapies. He performs complimentary collaborative clinical and multi-disciplinary studies and collaborates widely. He publishes extensively influential journals and is regularly invited to present internationally, including as plenary and to chair sessions. He has a substantial funding record of obtaining nationally competitive grant that support his group. He undertakes substantial mentoring and supervision activities of junior researchers, regularly sits on grant review panels and is on the editorial board of 3 journals.
Simon Hogan is a Tenured Associate Professor of Pediatrics, Director of Allergy and Immunology Research at Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA. Simon's NIH-funded research team is focused on understanding the contribution of intestinal epithelial–immune interactions in health and disease, with particular focus on food allergy, anaphylaxis, cystic fibrosis and inflammatory bowel diseases.
Kenya Honda is a professor in the Department of Microbiology and Immunology at Keio University School of Medicine, Tokyo, Japan. He is also a team leader in the laboratory of Gut Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. He received his M.D. from Kobe University School of Medicine and Ph.D. from Kyoto University School of Medicine in Japan. He worked with Tadatsugu Taniguchi at University of Tokyo as an assistant professor and with Kiyoshi Takeda at Osaka University as an associate professor before he started his own laboratory at RIKEN. His laboratory uses a combination of sequencing, gnotobiotic technique, anaerobic culturing to identify and isolate bacterial strains that have strong influences on the host physiology and diseases, with an emphasis on the human microbiome.
Mathias Hornef studied Medicine in Tübingen and Lübeck (Germany) as well as New York (USA) and Lausanne (Switzerland). He then worked as a research assistant and clinical fellow in Medical Microbiology at the Max von Pettenkofer Institute in Munich, Germany. Following his postdoctoral fellowship with Staffan Normark at the Karolinska Institute in Stockholm, Sweden, he finalized his clinical specialization and became independent researcher at the University of Freiburg and later Professor for Molecular Medical Microbiology at Hannover Medical School in Hannover, Germany. In 2014 he became director of the Institute of Medical Microbiology at the RWTH University Hospital in Aachen, Germany. His research focusses on the role of the intestinal epithelium in the host-microbial interplay with particular focus on the postnatal transition of the neonate, enteric infections and the establishment of host-microbial homeostasis.
Tracy Hussell completed her Ph.D. at University College London where she identified Helicobacter pylori as an aetiological agent in human gut lymphomas. After earning her Ph.D., Professor Hussell moved to Respiratory Medicine at St. Mary's Hospital to study immunity and pathology to respiratory syncytial virus. In 1998 she accepted a lectureship in the Centre for Molecular Microbiology and Infection (CMMI) at Imperial College led by Professors Gordon Dougan and Douglas Young. She was subsequently awarded a career development fellowship by the Medical Research Council. Professor Hussell was awarded a Personal Chair in Inflammatory Disease at Imperial College London in 2006 and has developed a vibrant research group studying immune health and its deregulation in the lung. Professor Hussell is currently the Director of the Manchester Collaborative Centre for Inflammation Research (MCCIR) at the University of Manchester.
Dr. Kiyono obtained his dental degree (D.D.S.) from Nihon University, and Ph. D. from the University of Alabama at Birmingham (UAB). His background as a dentist combined with extensive research experience in the field of Mucosal Immunology at UAB, Max-Planck Institute, Osaka University and now, the University of Tokyo make him exceptionally well qualified to discuss the current and future direction of mucosal immunology and mucosal vaccine.
Professor Nils Lycke is the Director of Mucosal Immunobiology & Vaccines (MIVAC) and Head of the Department of Clinical Immunology at the Sahlgrenska University Hospital in Gothenburg, Sweden. He is the principal investigator of several internationally recognized projects focused on mucosal immunity and tolerance. He has published over 170 original peer-reviewed papers and 29 reviews or book chapters. Dr. Lycke has helped pioneer the development of mucosal vaccines with important contributions to the field in adjuvant construction, including the patented CTA1-DD adjuvant. He has been the coordinator of 4 EU-sponsored projects and receives financial support from EU, NIH, Wellcome Trust, Swedish Cancer Foundation, The Norwegian Research Council, Novo Nordisk Foundation and the Swedish Research Council, and others. As a member of the WHO Transdisease Vaccinology Steering Committee for many years, Lycke has been deeply involved in vaccine design and development as well as interacting with industry and regulatory authorities. He has also organized several international meetings, including two keystone symposia, The European Mucosal Immunology Group (he is also founder of EMIG), and The International Mucosal Immunology Congress (SMI).
Andrew MacDonald completed his PhD at the University of Edinburgh in 1998, studying immunity to helminth parasites. After several years in the U.S., first at Cornell University and then at the University of Pennsylvania, he returned to the UK in 2002 to the University of Edinburgh where he established his laboratory through successive MRC Career Development and Senior Fellowships. In January 2013 he took up the position of Professor of Immunology at the University of Manchester. His research addresses some outstanding fundamental questions about activation and modulation of immunity by dendritic cells, with a particular emphasis on Type 2 inflammation — a defining feature of infection with parasitic worms, as well as being responsible for widespread suffering in allergies.
Peter J. Mannon, M.D., MPH is Professor of Medicine and Microbiology at the University of Alabama at Birmingham. He is a gastroenterologist specializing in the care of inflammatory bowel disease and GI complications of primary immunodeficiencies. He runs a translational laboratory that focuses on endotyping IBD, defining the mechanisms of response to novel therapeutic agents, and developing molecular biomarkers of disease.
Mike McGuckin is a NHMRC Senior Research Fellow and is Deputy Director (Research) at the Mater Medical Research Institute within the new Translational Research Institute in Brisbane, where he leads the Mucosal Diseases Research Group. Mike is the author of over 125 scientific publications with his research currently focused on mucosal infection and chronic inflammation in the gastrointestinal and respiratory tracts. He has particular interests in the role of secreted and cell surface mucin glycoproteins in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease. He is heavily involved in national and international peer review and is the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology.
Stephen McSorley received his Ph.D. from the University of Glasgow, Scotland, and subsequently completed post-doctoral fellowships at the CNRS-IPMC, Valbonne, France, and the University of Minnesota. He was a faculty member at the University of Connecticut Health Center from 2001-2005, returned to the University of Minnesota from 2005-2011, and moved to UC Davis in 2011. He is currently an Associate Professor in the Center for Comparative Medicine and a faculty member in the Graduate Group for Immunology. His research focuses on the examination of CD4 T cell and B cell responses to intestinal Salmonella infection and the interaction of bacterial flagellin with TLR5.
Professor Allan Mowat MBChB, Ph.D., FRCPath is Professor of Mucosal Immunology at the University of Glasgow and has been involved in research into the intestinal immune system since the 1970s. He has been a member of the SMI since its inception and is currently President-Elect of the society. He was a co-organizer of the ICMI in London in 1988 and was a founder of the European Mucosal Immunology Group. He is the organizer of its next meeting in Glasgow in 2014. As well as his research interests, he has a large teaching load and is a Consultant in Diagnostic Clinical Immunology in the NHS.
Cathryn Nagler graduated with honors from Barnard College and Columbia University, obtained her Ph.D. from the Sackler Institute of Biomedical Science at N.Y.U. School of Medicine and did a postdoctoral fellowship at M.I.T. She was Associate Professor of Pediatrics (Immunology) at Harvard Medical School prior to joining the University of Chicago in 2009. She is currently an elected Councilor of the Society for Mucosal Immunology. Dr. Nagler has a long-standing interest in the mechanisms governing tolerance to dietary antigens and the potential immunomodulatory features of this route of antigen administration. Her most recent work examines how intestinal bacteria regulate susceptibility to allergic responses to food. She is applying the insights gained from studying mouse models to the development of novel probiotic interventions for the prevention and treatment of food allergy.
Gabriel Nuñez earned his M.D. from the University of Seville, Spain. He received postdoctoral training in immunology at the University of Texas Southwestern Medical Center in Dallas, and residency training in anatomical pathology at Washington University in St. Louis. In 1987, he joined the laboratory of Stanley Korsmeyer at Washington University, where he studied the function of the antiapoptotic protein Bcl2. In 1991, he joined the Department of Pathology at the University of Michigan in Ann Arbor as an Assistant Professor and was promoted to Full Professor in 2001. He holds the Paul de Kruif Endowed Professorship in Academic Pathology. His laboratory identified NOD1 and NOD2, the first members of the Nod-like receptor (NLR) family, a class of pattern-recognition receptors that mediate cytosolic sensing of microbial organisms. Nuñez and colleagues showed that genetic variation in NOD2 is strongly associated with susceptibility to Crohn's disease. Currently, the Nuñez laboratory is interested in microbial-host interactions, the pathogenesis of inflammatory disease and the role of the microbiota in host defense and colitis. Dr. Nuñez is the author of more than 280 scientific publications. His research program is supported by grants from the National Institutes of Health, the Broad Foundation, the Crohn's and Colitis Foundation of America and the Bill and Melinda Gates Foundation.
Hiroshi Ohno received his M.D. in 1983 and Ph.D in 1991 from Chiba University, Japan. He is now a Group Director at RIKEN Center for Integrative Medical Sciences. His primary research interests involve the relationship between the host and gut microbiota, with a focus on intestinal epithelial M cells, and the role of gut microbiota in the intestinal immune system as well as the host health and disease conditions. His research has resulted in a Momofuku Ando Award in 2015. Dr. Ohno has been a member of the Society for Mucosal Immunology (SMI) since 2002.
Dr. Openshaw is Professor of Experimental Medicine, consultant physician and President of the British Society for Immunology (appointed 2014); theme lead on Infection for the Imperial College Biomedical Research Centre (2016); NIHR Senior Clinical Investigator; received the Chanock Award (2012) for RSV research; Croonian lecture (2013) on influenza pandemics. He served on UK Department of Health's advisory group on Influenza and is now vice-Chair of NERVTAG (UK emerging threats advisory group). Dr. Openshaw trained in respiratory medicine and T cell immunology, developing new methods of characterizing T cells (especially intracellular cytokine staining). He works on lung immunology, viral lung disease, vaccination and immunopathogenesis and especially on mouse models of respiratory virus infection. He led a consortium (‘MOSAIC') studying immunopathogenesis in hospitalized patients with influenza; now he directs studies of human volunteers experimentally infected with RSV. He has also co-authored over 200 scientific manuscripts (h-index 54).
Oliver Pabst studied Biotechnology and was trained in Developmental Biology before he focused on immunology and in 2009 became Professor of Mucosal Immunology at Hannover Medical School, Germany. The Pabst lab combines surgical manipulation of mice with genetic tools to understand the balancing of immunity and tolerance in the gut. Current projects investigate pathways of IgA induction by high throughput sequencing, the regulation of immune responses to food antigen and immune cell migratory routes.
Charles Parkos MD, PhD has had a career-long interest in basic mechanisms of inflammation, beginning with studies that were among the first to define the molecular basis of oxidant-mediated killing by neutrophils, followed by studies on the biology and molecular basis of interactions between leukocytes with epithelial cells. For the past 20 years, he has been a major contributor in studies on leukocyte transepithelial migration and effects on epithelial barrier function as it relates to pathologic mucosal inflammation. Parkos has applied state-of-the-art molecular/protein biochemisty approaches to complex cell biological systems and identified a number of epithelial and neutrophil proteins that play critical roles in mucosal inflammation, including CD11b/CD18, CD47, SIRP, and more recently, certain members of the JAM family of proteins, ICAM-1 as well as identified novel glycan-dependent interactions. He has extended studies to in-vivo animal models of inflammation that have provided key insights into the relationship between epithelial permeability and pathologic versus homeostatic inflammatory responses.
Dana Philpott is an Associate Professor in the Department of Immunology at the University of Toronto. Dr. Philpott obtained her PhD from the University of Toronto, where she studied host-pathogen interactions, focusing on enteropathogenic Escherichia coli infection of epithelial cells. She then did her post-doctoral work at the Institut Pasteur under the direction of Dr. Philippe Sansonetti and later became a group leader at this institute. Dr. Philpott was recruited to Toronto in 2006. Her research focus is to understand how Nod-like receptors influence gut homeostasis and how this might impact infection and disease pathogenesis. A particular interest is understanding Crohn's disease pathogenesis by studying the function of genes that have been linked to the development of this disease, including NOD2 and ATG16L1, as well as their interplay with the gut microbiota.
Fiona Powrie is the Sidney Truelove Professor of Gastroenterology and Director of the Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford. Her research interests include characterization of the interaction between the intestinal micro biota and the host immune system and how this mutualistic relationship breaks down in inflammatory bowel disease. Her work has identified the functional role of regulatory T cells in intestinal homeostasis and shed light on their development and mechanism of action. She has also shown that both adaptive and innate immune mechanisms contribute to intestinal inflammation and identified the IL-23 pathway as a pivotal player in the pathogenesis of chronic intestinal inflammation. Fiona Powrie received the Ita Askonas Award from the European Federation of Immunological Societies for her contribution to immunology in Europe and the Louis Jeantet Prize for Medicine 2012. She was elected a Fellow of the Royal Society in 2011 and of EMBO in 2013.
Anuradha Ray, PhD
Anuradha Ray is a Professor of Medicine and Immunology at the University of Pittsburgh School of Medicine. She received her Ph.D. from Calcutta University in India and underwent postdoctoral training at Cornell University in Ithaca, NY and at Rockefeller University in New York, NY. She was on the faculty at Rockefeller University and at Yale University between 1990 and 2001 before moving to the University of Pittsburgh. Dr. Ray's early research led to the first identification of NF-κB as a target for glucocorticoid-mediated repression of gene expression and the discovery of GATA-3 as an essential regulator of Th2 cells which promote asthma and allergic diseases. The primary goal of Dr. Ray's current research is to understand immune mechanisms involving interactions between dendritic cells (DCs) and T cells as they relate to chronic inflammatory diseases such as severe asthma or, on the flip side, to immune tolerance. She is also interested in mechanisms by which pathogens subvert the immune system. Her research has been continuously funded by multiple grants from the National Institutes of Health. She is an invited member of the Faculty of 1,000 Biology in the immunology discipline.
Dr. Rothenberg is the Director of the Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center and a tenured Professor of Pediatrics at Cincinnati Children's and the University of Cincinnati College of Medicine. He graduated summa cum laude with Highest Honors in Chemistry and Biochemistry from Brandeis University and the combined MD/PhD program at Harvard University. Dr. Rothenberg did a combined fellowship in Allergy/Immunology and Hematology at Children's Hospital in Boston. His research is focused on molecular analysis of allergic inflammation. His laboratory takes a multi-disciplinary approach including the development of preclinical murine models: genetics, genomics, molecular immunology, and biochemistry. He is the Founder and Director of the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) which is part of the Rare Disease Clinical Research Consortium Network of the NIH. He is an elected member of the ASCI, AAP, AAAS and SPR. His publications number over 300.
Dr. Barbara Shacklett is a virologist and immunologist whose laboratory focuses on mucosal immunity to HIV. Dr. Shacklett received her B.S. in Microbiology from Rutgers University, followed by a Ph.D. in Microbiology from the University of California. She completed postdoctoral training in virology at the Institut Cochin in Paris, France, and in cellular immunology at the Aaron Diamond AIDS Research Center in New York. In 2003, she was appointed to a faculty position at UC Davis, where she now holds the rank of tenured full professor. Dr. Shacklett's laboratory studies antiviral host defenses in mucosal tissues of the gastrointestinal and reproductive tracts. She is also involved in studies to develop mucosal vaccines and microbicides and to eradicate HIV from tissue reservoirs.
Ludvig M. Sollid is the Director of the Centre for Immune Regulation in Oslo, Norway, which is a Research Council of Norway and FOCIS (Federation of Clinical Immunology Societies) center of excellence. He is also Professor at the University of Oslo and a Senior Consultant at the Oslo University Hospital-Rikshospitalet. His laboratory investigates the mechanisms for association of MHC molecules with disease and the involvement of T and B cells in the pathogenesis of autoimmune disorders. Sollid has particularly been interested in deciphering the immune mechanism underlying celiac disease. He is the recipient of several research awards including the Research Council of Norway's Møbius Prize for Outstanding Research, the Warren Prize for Excellence in Celiac Disease Research, the Rank Prize in Nutrition and the UEG Research Prize.
Dr. Warren Strober is Chief of the Mucosal Immunity Section in the Laboratory of Host Defenses at NIH. His main areas of interest in Mucosal Immunology center around the pathogenesis of inflammatory bowel diseases and GI disease associated with immunodeficiency. His research in these areas has been recognized by several awards including the PHS Distinguished Service Medal, the Lifetime Achievement Award of SMI and the William Beaumont Award of the American Gastrointestinal Association. In addition, he was recognized as Doctor of Medicine, Honoris Causa by the Charite Hospital, Humboldt University. Finally, Dr. Strober served as President of the Society for Mucosal Immunity and has had the privilege of training many prominent members of the community of mucosal immunologists.
Kiyoshi Takeda graduated from Osaka University School of Medicine in 1992 and conducted his PhD work at the Graduate School of Medicine, Osaka University under the supervision of Prof. Shizuo Akira. He was an assistant professor in Hyogo College of Medicine, and Research Institute for Microbial Diseases, Osaka University, where he worked on the mechanisms for Toll-like receptor-dependent pathogen recognition. In 2003, he became a professor at Medical Institute of Bioregulation, Kyushu University, and then moved to Graduate School of Medicine, Osaka University in 2007. He is also a professor at WPI Immunology Frontier Research Center, Osaka University. His present research activity is focused on understanding the pathogenesis of inflammatory bowel diseases, particularly the analysis on how intestinal homeostasis is maintained by mucosal innate immune cells and epithelial cells.
Dale trained clinically as a pediatrician, allergist and immunologist, but developed research interests in the basic immunobiology of allergy and asthma. He studied subsets of CD4 T cells, NKT cells, Treg cells and innate lymphoid cells in the context of asthma and allergy, and has also led translational medicine studies in the areas of asthma and food allergy. He was a tenured professor at Stanford University and at Harvard Medical School as a researcher, teacher and clinician; currently he is a Principal Medical Director at Genentech in the Respiratory and Allergic Diseases Section, and a clinical/teaching professor at University of California, San Francisco. Dale severed SMI as Treasurer from 2007-2011, as a member of the Editorial Board of Mucosal Immunology from 2008, and as Associate Editor from 2009 to the present.
Jo Viney received her doctorate degree from St. Bartholomew's Hospital at the University of London in 1991. She then completed two postdoctoral fellowships — the first at the Imperial Cancer Research Fund in London, and the second at Genentech in South San Francisco. Following her training, Dr. Viney joined Immunex in Seattle in 1995 as a Staff Scientist. She remained at the company (which was acquired by Amgen in 2002) until leaving to join Biogen Idec in 2011. Dr. Viney's research revolves around understanding the mechanistic basis of immune homeostasis in organs susceptible to inflammatory disease. Her basic research interests have covered investigating tolerogenic antigen presentation in the intestine, new mouse models of colitis, and novel butyrophilin-like (BTNL) inhibitory molecules. Dr. Viney and her teams have also delivered multiple NMEs into clinical development for asthma, rheumatoid arthritis, psoriasis, lupus, and inflammatory bowel disease. She is also the Vice President of the Immunology Research group at Biogen Idec, and the Past President for the Society for Mucosal Immunology (SMI).