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Article
| Open AccessA modular and controllable T cell therapy platform for acute myeloid leukemia
- Mohamed-Reda Benmebarek
- , Bruno L. Cadilha
- , Monika Herrmann
- , Stefanie Lesch
- , Saskia Schmitt
- , Stefan Stoiber
- , Abbass Darwich
- , Christian Augsberger
- , Bettina Brauchle
- , Lisa Rohrbacher
- , Arman Oner
- , Matthias Seifert
- , Melanie Schwerdtfeger
- , Adrian Gottschlich
- , Felicitas Rataj
- , Nadja C. Fenn
- , Christian Klein
- , Marion Subklewe
- , Stefan Endres
- , Karl-Peter Hopfner
- & Sebastian Kobold
-
Article
| Open AccessLong-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis
- Hagop M. Kantarjian
- , Timothy P. Hughes
- , Richard A. Larson
- , Dong-Wook Kim
- , Surapol Issaragrisil
- , Philipp le Coutre
- , Gabriel Etienne
- , Carla Boquimpani
- , Ricardo Pasquini
- , Richard E. Clark
- , Viviane Dubruille
- , Ian W. Flinn
- , Slawomira Kyrcz-Krzemien
- , Ewa Medras
- , Maria Zanichelli
- , Israel Bendit
- , Silvia Cacciatore
- , Ksenia Titorenko
- , Paola Aimone
- , Giuseppe Saglio
- & Andreas Hochhaus
-
Article |
U2af1 is required for survival and function of hematopoietic stem/progenitor cells
- Avik Dutta
- , Yue Yang
- , Bao T. Le
- , Yifan Zhang
- , Omar Abdel-Wahab
- , Chongzhi Zang
- & Golam Mohi
-
Article |
High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib
- Tiziano Barbui
- , Alessandro Maria Vannucchi
- , Alberto Alvarez-Larran
- , Alessandra Iurlo
- , Arianna Masciulli
- , Alessandra Carobbio
- , Arianna Ghirardi
- , Alberto Ferrari
- , Giuseppe Rossi
- , Elena Elli
- , Marcio Miguel Andrade-Campos
- , Mercedes Gasior Kabat
- , Jean-Jaques Kiladjian
- , Francesca Palandri
- , Giulia Benevolo
- , Valentin Garcia-Gutierrez
- , Maria Laura Fox
- , Maria Angeles Foncillas
- , Carmen Montoya Morcillo
- , Elisa Rumi
- , Santiago Osorio
- , Petros Papadopoulos
- , Massimiliano Bonifacio
- , Keina Susana Quiroz Cervantes
- , Miguel Sagues Serrano
- , Gonzalo Carreno-Tarragona
- , Marta Anna Sobas
- , Francesca Lunghi
- , Andrea Patriarca
- , Begona Navas Elorza
- , Anna Angona
- , Elena Magro Mazo
- , Steffen Koschmieder
- , Marco Ruggeri
- , Beatriz Cuevas
- , Juan Carlos Hernandez-Boluda
- , Emma Lopez Abadia
- , Blanca Xicoy Cirici
- , Paola Guglielmelli
- , Marta Garrote
- , Daniele Cattaneo
- , Rosa Daffini
- , Fabrizio Cavalca
- , Beatriz Bellosillo
- , Lina Benajiba
- , Natalia Curto-Garcia
- , Marta Bellini
- , Silvia Betti
- , Valerio De Stefano
- , Claire Harrison
- & Alessandro Rambaldi
-
Article |
Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2P95-mutated neoplasms
- Gabriele Todisco
- , Maria Creignou
- , Anna Gallì
- , Paola Guglielmelli
- , Elisa Rumi
- , Marco Roncador
- , Ettore Rizzo
- , Yasuhito Nannya
- , Daniela Pietra
- , Chiara Elena
- , Elisa Bono
- , Elisabetta Molteni
- , Vittorio Rosti
- , Silvia Catricalá
- , Martina Sarchi
- , Marios Dimitriou
- , Johanna Ungerstedt
- , Alessandro Maria Vannucchi
- , Eva Hellström-Lindberg
- , Seishi Ogawa
- , Mario Cazzola
- & Luca Malcovati
-
Letter
| Open AccessPhase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma
- Franck Morschhauser
- , Martin J. S. Dyer
- , Harriet S. Walter
- , Alexey V. Danilov
- , Loic Ysebaert
- , Daniel James Hodson
- , Christopher Fegan
- , Simon A. Rule
- , John Radford
- , Guillaume Cartron
- , Krimo Bouabdallah
- , Andrew John Davies
- , Stephen Spurgeon
- , Nishanthan Rajakumaraswamy
- , Biao Li
- , Rita Humeniuk
- , Xi Huang
- , Pankaj Bhargava
- , Juliane M. Jürgensmeier
- & Gilles Salles
-
Perspective |
Optimal dosing of cytarabine in induction and post-remission therapy of acute myeloid leukemia
- Roland B. Walter
- , Frederick R. Appelbaum
- & Elihu H. Estey
-
Article
| Open AccessValue of flow cytometry for MRD-based relapse prediction in B-cell precursor ALL in a multicenter setting
- S. Modvig
- , H. Hallböök
- , H. O. Madsen
- , S. Siitonen
- , S. Rosthøj
- , A. Tierens
- , V. Juvonen
- , L. T. N. Osnes
- , H. Vålerhaugen
- , M. Hultdin
- , R. Matuzeviciene
- , M. Stoskus
- , M. Marincevic
- , A. Lilleorg
- , M. Ehinger
- , U. Norén-Nystrøm
- , N. Toft
- , M. Taskinen
- , O. G. Jónsson
- , K. Pruunsild
- , G. Vaitkeviciene
- , K. Vettenranta
- , B. Lund
- , J. Abrahamsson
- , A. Porwit
- , K. Schmiegelow
- & H. V. Marquart
-
Correspondence
| Open AccessSARS-CoV-2 antibody responses in patients with acute leukaemia
- J. O’Nions
- , L. Muir
- , J. Zheng
- , C. Rees-Spear
- , A. Rosa
- , C. Roustan
- , C. Earl
- , P. Cherepanov
- , R. Gupta
- , A. Khwaja
- , C. Jolly
- & L. E. McCoy
-
Review Article
| Open AccessClinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy
- Stefania Trino
- , Daniela Lamorte
- , Antonella Caivano
- , Luciana De Luca
- , Alessandro Sgambato
- & Ilaria Laurenzana
-
Article |
Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression
- Binu Sasi
- , Purushoth Ethiraj
- , Jamie Myers
- , An-Ping Lin
- , Shoulei Jiang
- , Zhijun Qiu
- , Kenneth N. Holder
- & Ricardo C. T. Aguiar
-
Article |
Targeted inhibition of cooperative mutation- and therapy-induced AKT activation in AML effectively enhances response to chemotherapy
- Montserrat Estruch
- , Kristian Reckzeh
- , Camilla Vittori
- , Anders Centio
- , Mina Ali
- , Sophia Engelhard
- , Ling Zhao
- , Kyoung Jae Won
- , Paul Liu
- , Bo Torben Porse
- & Kim Theilgaard-Mönch
-
Review Article
| Open AccessCXCR4 in Waldenström’s Macroglobulinema: chances and challenges
- Lisa Marie Kaiser
- , Zachary R. Hunter
- , Steven P. Treon
- & Christian Buske
-
Article |
Association between high-density lipoprotein cholesterol level and risk of hematologic malignancy
- Su-Min Jeong
- , Taewoong Choi
- , Dahye Kim
- , Kyungdo Han
- , Seok Jin Kim
- , Sang Youl Rhee
- , Edward L. Giovannucci
- & Dong Wook Shin
-
Correction |
Correction: CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC
- I. Tirado-Gonzalez
- , E. Czlonka
- , A. Nevmerzhitskaya
- , D. Soetopo
- , E. Bergonzani
- , A. Mahmoud
- , A. Contreras
- , I. Jeremias
- , U. Platzbecker
- , J. P. Bourquin
- , U. Kloz
- , F. Van der Hoeven
- & H. Medyouf
-
Article |
A highly heterogeneous mutational pattern in POEMS syndrome
- Jia Chen
- , Xue-min Gao
- , Hao Zhao
- , Hao Cai
- , Lu Zhang
- , Xin-xin Cao
- , Dao-bin Zhou
- & Jian Li
-
Letter
| Open AccessFAM122A is required for hematopoietic stem cell function
- Man-Hua Liu
- , Xiao-Cui Zhang
- , Jing Chen
- , Yun-Sheng Yang
- , Yin-Qi Wang
- , Jun-Ke Zheng
- , Guo-Qiang Chen
- & Ying Huang
-
Letter |
HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia
- Oriol de Barrios
- , Alexandros Galaras
- , Juan L. Trincado
- , Alba Azagra
- , Olga Collazo
- , Ainara Meler
- , Antonio Agraz-Doblas
- , Clara Bueno
- , Paola Ballerini
- , Giovanni Cazzaniga
- , Ronald W. Stam
- , Ignacio Varela
- , Paola De Lorenzo
- , Maria Grazia Valsecchi
- , Pantelis Hatzis
- , Pablo Menéndez
- & Maribel Parra
-
Letter |
BCR-ABL1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analyzed by NGS
- Simona Soverini
- , Margherita Martelli
- , Luana Bavaro
- , Caterina De Benedittis
- , Simona Sica
- , Federica Sorà
- , Alessandra Iurlo
- , Massimiliano Bonifacio
- , Patrizia Pregno
- , Sara Galimberti
- , Francesca Lunghi
- , Francesco Albano
- , Mariella D’Adda
- , Monica Crugnola
- , Isabella Capodanno
- , Fausto Castagnetti
- , Gabriele Gugliotta
- , Cristina Papayannidis
- , Gianantonio Rosti
- , Antonio Percesepe
- , Flavio Mignone
- , Michele Baccarani
- , Giovanni Martinelli
- & Michele Cavo
-
Article
| Open AccessmiR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia
- Thi Thanh Vu
- , Friedrich Stölzel
- , Kristy W. Wang
- , Christoph Röllig
- , Melinda L. Tursky
- , Timothy J. Molloy
- & David D. Ma
-
Article
| Open AccessCopy number evolution and its relationship with patient outcome—an analysis of 178 matched presentation-relapse tumor pairs from the Myeloma XI trial
- James Croft
- , Sidra Ellis
- , Amy L. Sherborne
- , Kim Sharp
- , Amy Price
- , Matthew W. Jenner
- , Mark T. Drayson
- , Roger G. Owen
- , Sally Chown
- , Jindriska Lindsay
- , Kamaraj Karunanithi
- , Hannah Hunter
- , Walter M. Gregory
- , Faith E. Davies
- , Gareth J. Morgan
- , Gordon Cook
- , Lilit Atanesyan
- , Suvi Savola
- , David A. Cairns
- , Graham Jackson
- , Richard S. Houlston
- & Martin F. Kaiser
-
Letter
| Open AccessSTAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma
- Cosimo Lobello
- , Boris Tichy
- , Vojtech Bystry
- , Lenka Radova
- , Daniel Filip
- , Marek Mraz
- , Ivonne-Aidee Montes-Mojarro
- , Nina Prokoph
- , Hugo Larose
- , Huan-Chang Liang
- , Geeta G. Sharma
- , Luca Mologni
- , David Belada
- , Katerina Kamaradova
- , Falko Fend
- , Carlo Gambacorti-Passerini
- , Olaf Merkel
- , Suzanne D. Turner
- , Andrea Janikova
- & Sarka Pospisilova
-
Article |
Fit older adults with advanced myelodysplastic syndromes: who is most likely to benefit from transplant?
- Gregory A. Abel
- , Haesook T. Kim
- , Andrew Hantel
- , David P. Steensma
- , Richard Stone
- , Anand Habib
- , Vincent T. Ho
- , Martha Wadleigh
- , Areej El-Jawahri
- , Edwin P. Alyea
- , Daniel J. DeAngelo
- , John Koreth
- , Joseph H. Antin
- , Robert J. Soiffer
- & Corey Cutler
-
Article |
A new pre-emptive TKIs strategy for preventing relapse based on BCR/ABL monitoring for Ph+ALL undergoing allo-HCT: a prospective clinical cohort study
- Hui Liu
- , Li Xuan
- , Ren Lin
- , Lan Deng
- , Zhiping Fan
- , Danian Nie
- , Xudong Li
- , Xinquan Liang
- , Dan Xu
- , Yu Zhang
- , Na Xu
- , Jieyu Ye
- , Hua Jin
- , Dongjun Lin
- , Liping Ma
- , Jing Sun
- , Fen Huang
- & Qifa Liu
-
Letter |
Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model
- Toshihiro Tomii
- , Toshihiko Imamura
- , Kuniaki Tanaka
- , Itaru Kato
- , Azusa Mayumi
- , Emi Soma
- , Mio Yano
- , Kenichi Sakamoto
- , Takashi Mikami
- , Makiko Morita
- , Nobutaka Kiyokawa
- , Keizo Horibe
- , Souichi Adachi
- , Tatsutoshi Nakahata
- , Junko Takita
- & Hajime Hosoi
-
Article |
Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia
- Ashkan Emadi
- , Bandish Kapadia
- , Dominique Bollino
- , Binny Bhandary
- , Maria R. Baer
- , Sandrine Niyongere
- , Erin T. Strovel
- , Hannah Kaizer
- , Elizabeth Chang
- , Eun Yong Choi
- , Xinrong Ma
- , Kayla M. Tighe
- , Brandon Carter-Cooper
- , Blake S. Moses
- , Curt I. Civin
- , Anup Mahurkar
- , Amol C. Shetty
- , Ronald B. Gartenhaus
- , Farin Kamangar
- & Rena G. Lapidus
-
-
Letter
| Open AccessDynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian
- Erik B. van den Akker
- , Stavros Makrodimitris
- , Marc Hulsman
- , Martijn H. Brugman
- , Tatjana Nikolic
- , Ted Bradley
- , Quinten Waisfisz
- , Frank Baas
- , Marja E. Jakobs
- , Daphne de Jong
- , P. Eline Slagboom
- , Frank J. T. Staal
- , Marcel J. T. Reinders
- & Henne Holstege
-
Article |
A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma
- Hongbo Wang
- , Wei Wei
- , Jing-Ping Zhang
- , Zhihui Song
- , Yangyang Li
- , Wenming Xiao
- , Yijun Liu
- , Mu-Sheng Zeng
- , Michael N. Petrus
- , Craig J. Thomas
- , Marshall E. Kadin
- , Masao Nakagawa
- , Thomas A. Waldmann
- & Yibin Yang
-
Letter
| Open AccessLow-dose ruxolitinib plus steroid in severe SARS-CoV-2 pneumonia
- A. D’Alessio
- , P. Del Poggio
- , F. Bracchi
- , G. Cesana
- , N. Sertori
- , D. Di Mauro
- , A. Fargnoli
- , M. Motta
- , C. Giussani
- , P. Moro
- , G. Vitale
- , M. Giacomini
- & G. Borra
-
Article |
IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells
- Zhiwu Jiang
- , Rui Liao
- , Jiang Lv
- , Shanglin Li
- , Diwei Zheng
- , Le Qin
- , Di Wu
- , Suimin Chen
- , Youguo Long
- , Qiting Wu
- , Suna Wang
- , Simiao Lin
- , Xiaohan Huang
- , Zhaoyang Tang
- , Pengcheng Shi
- , Hongsheng Zhou
- , Qifa Liu
- , Ruocong Zhao
- , Yangqiu Li
- , Yang Jie
- , Wei Wei
- , Peilong Lai
- , Xin Du
- , Shuzhong Cui
- , Robert Weinkove
- , Pentao Liu
- , Duanqing Pei
- , Yao Yao
- & Peng Li
-
Article
| Open AccessCharacterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets
- Shady Adnan-Awad
- , Daehong Kim
- , Helena Hohtari
- , Komal Kumar Javarappa
- , Tania Brandstoetter
- , Isabella Mayer
- , Swapnil Potdar
- , Caroline A. Heckman
- , Soili Kytölä
- , Kimmo Porkka
- , Eszter Doma
- , Veronika Sexl
- , Matti Kankainen
- & Satu Mustjoki
-
Article |
Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells
- Thao Trinh
- , James Ropa
- , Arafat Aljoufi
- , Scott Cooper
- , Anthony Sinn
- , Edward F. Srour
- & Hal E. Broxmeyer
-
Article
| Open AccessBcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice
- Paolo Sportoletti
- , Daniele Sorcini
- , Anna G. Guzman
- , Jaime M. Reyes
- , Arianna Stella
- , Andrea Marra
- , Sara Sartori
- , Lorenzo Brunetti
- , Roberta Rossi
- , Beatrice Del Papa
- , Francesco Maria Adamo
- , Giulia Pianigiani
- , Camilla Betti
- , Annarita Scialdone
- , Valerio Guarente
- , Giulio Spinozzi
- , Valentina Tini
- , Maria Paola Martelli
- , Margaret A. Goodell
- & Brunangelo Falini
-
Letter |
The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival
- Pasquale L. Fedele
- , Yang Liao
- , Jia-nan Gong
- , Yuan Yao
- , Mark F. van Delft
- , Michael S. Y. Low
- , Lin Tai
- , Marco J. Herold
- , Jacob T. Jackson
- , Charis E. Teh
- , Tania Tan
- , Lorraine A. O’Reilly
- , Julie Tellier
- , George Grigoriadis
- , David C. S. Huang
- , Wei Shi
- , Stephen L. Nutt
- & Simon N. Willis
-
Article |
Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
- Christoph Rummelt
- , Sivahari P. Gorantla
- , Manja Meggendorfer
- , Anne Charlet
- , Cornelia Endres
- , Konstanze Döhner
- , Florian H. Heidel
- , Thomas Fischer
- , Torsten Haferlach
- , Justus Duyster
- & Nikolas von Bubnoff
-
Review Article |
Targeting RNA-binding proteins in acute and chronic leukemia
- Irina A. Elcheva
- & Vladimir S. Spiegelman
-
Article |
DPP4+ exosomes in AML patients’ plasma suppress proliferation of hematopoietic progenitor cells
- Swathi Namburi
- , Hal E. Broxmeyer
- , Chang-Sook Hong
- , Theresa L. Whiteside
- & Michael Boyiadzis
-
Review Article |
ADARs, RNA editing and more in hematological malignancies
- Phaik Ju Teoh
- , Mun Yee Koh
- & Wee Joo Chng
-
Correspondence |
PTPN11 mutations are associated with poor outcomes across myeloid malignancies
- David M. Swoboda
- , Najla Al Ali
- , Onyee Chan
- , Eric Padron
- , Andrew T. Kuykendall
- , Jinming Song
- , Mohammad Hussaini
- , Chetasi Talati
- , Kendra Sweet
- , Jeffrey E. Lancet
- , David A. Sallman
- & Rami S. Komrokji
-
Letter |
Short term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial BTK inhibitor therapy for CLL or lymphoplasmacytic lymphoma
- Clive S. Zent
- , Michael T. Brady
- , Carolyne Delage
- , Myla Strawderman
- , Nathan Laniewski
- , Phuong N. Contant
- , Preshetha Kanagaiah
- , Mark Y. Sangster
- , Paul M. Barr
- , Charles C. Chu
- , David J. Topham
- & Jonathan W. Friedberg
-
Review Article |
New strategies to treat AML: novel insights into AML survival pathways and combination therapies
- Ramya Nair
- , Alejandro Salinas-Illarena
- & Hanna-Mari Baldauf
-
Review Article
| Open AccessInhibitors targeting Bruton’s tyrosine kinase in cancers: drug development advances
- Tingyu Wen
- , Jinsong Wang
- , Yuankai Shi
- , Haili Qian
- & Peng Liu
-
Correspondence |
Systemic mastocytosis with acute myeloid leukemia occurs from mutually exclusive clones expressing KITD816V and FLT3-ITD
- Jose-Mario Capo-Chichi
- , Elizabeth Kagotho
- , Rakesh Nayyar
- , Davidson Zhao
- , Mark Minden
- & Hong Chang
-
Correspondence |
COVID-19 and myeloproliferative neoplasms: some considerations
- Baransel Kamaz
- & Ann Mullally
-
Article
| Open AccessXenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity
- Sandrine Poglio
- , Martina Prochazkova-Carlotti
- , Floriane Cherrier
- , Audrey Gros
- , Elodie Laharanne
- , Anne Pham-Ledard
- , Marie Beylot-Barry
- & Jean-Philippe Merlio
-
Correction |
Corrections: Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine
- S. Pützer
- , L. Varghese
- , J. von Jan
- , T. Braun
- , A. K. Giri
- , P. Mayer
- , N. Riet
- , S. Timonen
- , S. Oberbeck
- , H. Kuusanmäki
- , S. Mustjoki
- , M.-H. Stern
- , T. Aittokallio
- , S. Newrzela
- , A. Schrader
- & M. Herling
-
Article
| Open AccessWnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism
- Md Kamrul Hasan
- , Emanuela M. Ghia
- , Laura Z. Rassenti
- , George F. Widhopf II
- & Thomas J. Kipps
-
Article |
A trispecific killer engager molecule against CLEC12A effectively induces NK-cell mediated killing of AML cells
- Upasana Sunil Arvindam
- , Paulien M. M. van Hauten
- , Dawn Schirm
- , Nicolaas Schaap
- , Willemijn Hobo
- , Bruce R. Blazar
- , Daniel A. Vallera
- , Harry Dolstra
- , Martin Felices
- & Jeffrey S. Miller
