Cover:In this issue, the paper by Tourkova et al describes how the HDL Receptor Scarb1 is required for normal bone differentiation. The cover shows the appearance of mouse vertebral trabecular bone at 8 and 16 weeks.

The cover shows cardiac sections from a 4C30 mouse, which harbors sialyltransferase transgenes, and from a wild-type mouse. Stain: Masson’s trichrome. For more information, see the paper by Nagai-Okatani et al, p. 1749, this issue.

The cover shows Retinal vascular leakage in diabetic Nile rats. For more information, see the paper by Toh et al, p. 1547.

The cover shows that mesenchymal deletion of Tgf-β1 does not affect mouse lung epithelial cell differentiation. For more information, see the paper by Noe et al, p 1367, this issue.

The paper by Liu et al (page 1193,this issue) presents a novel mechanism whereby epigenetic regulation of scar formation may be manipulated at the level of fibroblast DNA hydroxymethylation. The cover shows immunofluorescence staining of human fibroblasts for F actin (green) and phosphorylated focal adhesion kinase (red dots; blue = DAPI).

The cover shows immunofluorescence analysis of cholinergic neurons in basal forebrain. Cholinergic neurons decreased with aging, and anesthesia/surgery profoundly reduced cholinergic neurons in aged mice.For more information, see the paper by Xu et al, page 1078, this issue.

In this issue, the paper by Inoue et al(page 885) outlines the spontaneous correction from chromosome 21 trisomy to disomy without genetic manipulation, chemical treatment or exposure to irradiation. The cover shows generation of keratinocytes from induced pluripotent stem cells.

In this issue, the paper by Xie et al (p. 625) describes how lipopolysaccharide promotes lung fibroblast proliferation through autophagy inhibition via activation of the PI3K-Akt-mTOR pathway. The cover shows transmission electron microscopy of autophagosomes in mouse lung fibroblasts.

The review by Dave et al (page 452, this issue) discusses microRNA amplification and detection technologies in the context of opportunities and challenges for point of care diagnostics. The cover shows approaches based on oligonucleotide-templated reactions and nanobeads.

In this issue, Pepin et al (p 371), define a novel connection between genome-wide DNA methylation and cardiac metabolic remodeling in human ischemic heart failure. The cover art illustrates how epigenomic reprogramming of the human left ventricle specifically impacts metabolic gene expression in the context of cardiac ischemia.

In this issue, the paper by Okada et al (p 210) describes how the trigeminal sensory nerve is critical for maintenance of corneal epithelial stem cells in the corneal limbus. The cover shows immunofluorescence of corneal sensory nerves.

In this issue, the paper by Fan et al (p 17) describes how the cytoskeletal GTPase SEPT6 plays an important role in hepatic stellate cell activation and liver fibrosis. The cover shows immunofluorescent staining of α-smooth muscle actin and SEPT6 in human liver.