Volume 102

  • No. 7 July 2022

    The cover shows MIBI-TOF imaging data from an archival human tissue microarray of squamous cell carcinoma. For more information, see the paper by Liu et al, this issue (p 762).

  • No. 6 June 2022

    The cover shows a gradient-weighted class activation map for well-differentiated adenocarcinoma. Hot regions correspond to key features for deep learning models to recognize well-differentiated adenocarcinoma. For more information, see the paper by Su et al, p 641, this issue.

  • No. 5 May 2022

    In this issue, the paper by Li et al (p 534) illustrates that interactions between leucines within the signal peptides of megalin and stannio-calcin-1 are crucial for regulation of mitochondrial metabolism. The cover shows by deconvolution confocal microscopy that stannio-calcin-1 fails to enter the cell or reach the mitochondria when applied to Lrp2-knockout mouse embryonal fibroblasts expressing mutant megalin.

  • No. 4 April 2022

    The cover shows expression of E-cadherin, N-cadherin, α-smooth muscle actin and p-Smad2 by immunofluorescence in untreated or high glucose-treated lens epithelial cells after treatment with a negative control or a miR-204-3p mimic. For more information see the paper by Li et al, this issue (p 452).

  • No. 3 March 2022

    The paper by Mohapatra et al. (p 298, this issue) describes how fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and/or TGF-β-induced tumor-associated fibrosis. The cover shows images of developing zebrafish embryos as a model for this study.

  • No. 2 February 2022

    In this issue (p 172), Innes et al present an experimental approach to simultaneously barcode and phenotype glioma initiating cells to assess their functional properties The cover shows the clonal populations that emerge during passaging of barcode-labelled cells.

  • No. 1 January 2022

    In this issue, the paper by Bai et al. (p 57) describes how hepatitis B virus crosses placenta to cause infection in utero. The cover shows co-localization of the GTPase Rab7 and HBsAg in Swan 71 cells infected with hepatitis B virus.