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The cover shows image patches cropped from slides that were used as training input in a deep learning system for gynecologic cytopathology. For more information, see the paper by Ke et al, this issue (p 513).
In this issue, the paper by Yamazaki et al describes how continuous formation of small clusters of LGR5-positive cells contribute to tumor growth in colorectal cancer. The cover shows distribution of LGR5-positive cells (green) and HLA-DMA (red) in 3D structures.