Volume 101

  • No. 12 December 2021

    The cover shows immunofluorescence of F-actin and cathepsin K in tunneling nanotubes observed during osteoclastogenesis in RAW-D cells. For more information, see the paper by Zhang et al, this issue, p. 1571.

  • No. 11 November 2021

    The cover shows the histological relationship between osteoclasts and blood vessels in normal and arthritic rats. For more information, see the paper by Kukita et al, this issue, p 1449.

  • No. 10 October 2021

    Cover Caption: The cover shows images of chemically-oligomerizable TAR DNA-binding protein-43, which mimics amyotrophic lateral sclerosis pathology in mammalian cells. For more information, see the paper by Yamanaka et al, this issue, p 1331.

  • No. 9 September 2021

    The cover shows an immunofluorescent image of a flat-mounted mid-ventral retina from a thirteen-lined-ground squirrel. To learn about the ground squirrel as a superb model for retinal ganglion cell disorders and optic neuropathies, see the paper by Xiao et al, this issue, p 1289.

  • No. 8 August 2021

    The cover shows DSS1 and PCID2 immunohistochemistry results in normal breast tissue (left), ductal carcinoma in situ (center), and invasive ductal carcinoma (right). DSS1 expression tended to be higher with increased malignancy, whereas PCID2 was always expressed. For more information, see the paper by Gondo et al, p 1048 this issue.

  • No. 7 July 2021

    The cover shows the postulated neurogenic and direct mechanisms through which serotonin receptors and TRPV4 may induce tissue edema. For more information, see the paper by Retamal et al, this issue, p 851.

  • No. 6 June 2021

    The cover shows morphological manifestations of skeletal muscle contusion in wild-type mice and PD-1-/- mice. For more information, see the paper by Shou et al, this issue (p 719).

  • No. 5 May 2021

    The cover shows immunofluorescent images of activating transcription factor 3 (red) and MART-1 (Melan-A; green) in human melanocytic specimens and tissue microarrays. For more information, see the paper by Zu et al, this issue (p 636).

  • No. 4 April 2021

    The cover shows image patches cropped from slides that were used as training input in a deep learning system for gynecologic cytopathology. For more information, see the paper by Ke et al, this issue (p 513).

  • No. 3 March 2021

    The cover shows an example of a multiplexed immunofluorescence-stained patient derived explant. For more information see the paper by Miles et al, this issue (p 396).

  • No. 2 February 2021

    The cover shows immunofluorescent double staining of ZO-1 and RPE65 in retinal pigment epithelial cells. For more information, see the paper by Lennikov et al, p 232, this issue.

  • No. 1 January 2021

    In this issue, the paper by Yamazaki et al describes how continuous formation of small clusters of LGR5-positive cells contribute to tumor growth in colorectal cancer. The cover shows distribution of LGR5-positive cells (green) and HLA-DMA (red) in 3D structures.