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Volume 101 Issue 3, March 2021

Volume 101 Issue 3

The cover shows an example of a multiplexed immunofluorescence-stained patient derived explant. For more information see the paper by Miles et al, this issue (p 396).

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Mini Review

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    Disorders involving injury to tissue stem cells may show unusually devastating clinical consequences. In acute graft-versus-host disease (aGVHD) relatively few cytotoxic immune cells target skin stem cells to produce significant morbidity and mortality. By analogy, SARS-CoV-2 initially homes to pulmonary stem cells that preferentially express the ACE2 receptor, thus potentially incurring similarly robust pathological consequences. As with aGVHD, lung stem cell targeting is a potential co-factor in explaining age-related severity of COVID-19 infection.

    • George F. Murphy

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