Volume 101 Issue 3, March 2021

The cover shows an example of a multiplexed immunofluorescence-stained patient derived explant. For more information see the paper by Miles et al, this issue (p 396).

Inside the USCAP Journals

Inside the USCAP Journals | 18 February 2021

Inside the USCAP Journals
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- Our Monthly Top Picks

Mini Review

Mini Review | 09 December 2020

COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters)

Disorders involving injury to tissue stem cells may show unusually devastating clinical consequences. In acute graft-versus-host disease (aGVHD) relatively few cytotoxic immune cells target skin stem cells to produce significant morbidity and mortality. By analogy, SARS-CoV-2 initially homes to pulmonary stem cells that preferentially express the ACE2 receptor, thus potentially incurring similarly robust pathological consequences. As with aGVHD, lung stem cell targeting is a potential co-factor in explaining age-related severity of COVID-19 infection.
- George F. Murphy
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- Our Monthly Top Picks

Article

Article | 21 August 2020

Acidosis induces synovial fibroblasts to release vascular endothelial growth factor via acid-sensitive ion channel 1a

Both ASIC1a and VEGF are highly expressed in rheumatoid arthritis synovial tissue and are associated with vascular disease. Interfering with ASIC1a in vitro using silencing, blocking, and overexpression interferes with the release of VEGF under acid stimulation. Blocking ASIC1a in the articular cavity of rats with adjuvant arthritis not only reduces the expression of VEGF in the synovium, but also reduces the proliferation and lesions of blood vessels and interferes with the development of the disease.
- Xuewen Qian
- , Yihao Zhang
- & Feihu Chen
Article | 01 December 2020

Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells

Nitric oxide (NO) plays an important role in tumor biology, including the generation and maintenance of cancer stem cells (CSCs) subpopulations. Here the authors show that the inhibition of NO production in estrogen-positive breast cancer not only impact the CSC subpopulation but also enhance the efficacy of hormonal therapy with tamoxifen.
- Laura M. López-Sánchez
- , Rafael Mena
- & Antonio Rodríguez-Ariza
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- Our Monthly Top Picks
Article | 10 December 2020 | Open Access

Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway

Vascular endothelial growth factor secreted by placenta-derived mesenchymal stem cells (PD-MSCs) promotes follicular development and ovarian function after ovariectomy through vascular remodeling. These results provide fundamental data for understanding the therapeutic mechanisms of stem cell therapy based on placenta-derived mesenchymal stem cells PD-MSCs and provide a theoretical foundation for their application for obstetrical and gynecological diseases, including infertility and menopause.
- Jinki Cho
- , Tae-Hee Kim
- & Gi Jin Kim
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- Our Monthly Top Picks
Article | 05 January 2021

Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation

The abnormal differentiation of Th17 cells is a vital promoter of immune thrombocytopenia (ITP) progression. In this study, the authors found that miR-199a-5p is downregulated during ITP. Supplementation of extracellular vesicles (EVs) derived from miR-199a-5p-modified ADSCs markedly repress Th17 differentiation by transferring miR-199a-5p to CD4⁺T cells, thus ameliorating experimental ITP.
- Jianqin Li
- , Yanlin Xia
- & Zhaoyue Wang
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- Our Monthly Top Picks
Article | 18 January 2021

Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells

Using approaches involving chimeric mice and macrophage-adipocyte cocultures, the authors demonstrate that PFKFB3 disruption only in hematopoietic cells exacerbates the severity of diet-induced adipose tissue inflammation and systemic insulin resistance. Mechanistically, macrophage factors generated in response to PFKFB3 disruption act to enhance adipocyte proinflammatory responses and impair adipocyte insulin signaling.
- Bilian Zhu
- , Xin Guo
- & Chaodong Wu
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- Our Monthly Top Picks
Article | 14 December 2020

LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia

This study reveals that upregulation of lncRNA small nucleolar RNA host gene 5 (SNHG5), mediated by Yin Yang 1 (YY1), activates connective tissue growth factor (CTGF)/vascular endothelial growth factor (VEGFA) axis via targeting miR-26b to regulate angiogenesis of acute myelogenous leukemia (AML), providing new insights into mechanisms of AML.
- Zhen-Jiang Li
- , Jing Cheng
- & Ji-Fu Zheng
Article | 12 December 2020 | Open Access

PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages

The authors show that plasminogen activator inhibitor-1 (PAI-1) derived from cancer-associated fibroblasts promotes the invasion of esophageal squamous cell carcinoma (ESCC) cells and the migration of macrophages via lipoprotein receptor-related protein 1 (LRP1). High expression of PAI-1 and/or LRP1 is associated with poor prognosis in patients with ESCC, and the PAI-1/LRP1 axis could be a target of anticancer therapy.
- Hiroki Sakamoto
- , Yu-ichiro Koma
- & Hiroshi Yokozaki
Collection:
- Our Monthly Top Picks
Article | 02 December 2020

Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin

This study shows that exercise increases adropin levels and inhibits NLRP3 inflammasome activation in mice with diet-induced nonalcoholic steatohepatitis (NASH). Furthermore, adropin suppresses palmitic acid-induced NLRP3 inflammasome activation in hepatocytes and Kupffer cells. These results indicate that exercise may inhibit NLRP3 inflammasome activation via adropin induction, resulting in NASH improvement.
- Wenqi Yang
- , Ling Liu
- & Liangming Li
Collection:
- Our Monthly Top Picks
Article | 22 January 2021

Real-time lipid patterns to classify viable and necrotic liver tumors

Real-time lipid patterns can identify liver tumors and their inter-tumor and intra-tumor heterogeneity. Ceramides and related sphingolipids are a common feature of necrotic tumors and can characterize the tumor phenotype based on metabolic shifts relevant for cell death pathways. Lipid patterns have the potential to improve clinical decision-making in the near future.
- Pierre-Maxence Vaysse
- , Heike I. Grabsch
- & Tiffany Porta Siegel
Collections:
- Advances in Translational Pathology
- Our Monthly Top Picks
Article | 14 December 2020

Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants

This paper reports the optimisation of digital pathology approaches for evaluating drug responses in patient-derived explants at endpoint. The authors compare three image analysis software platforms and find that all three generate comparable data to that of a histomorphometrist. They also demonstrate the power of multi-immunofluorescence staining for monitoring multiple biomarkers simultaneously compared to virtual double staining of sequential sections by immunohistochemistry.
- Gareth J. Miles
- , Ian Powley
- & Catrin Pritchard
Collection:
- Our Monthly Top Picks

Supplement

Supplement | 15 March 2021

United States & Canadian Academy of Pathology 110th Annual Meeting Abstracts: Never Stop Learning

Volume 101 Issue 3, March 2021

Inside the USCAP Journals

Inside the USCAP Journals

Mini Review

COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters)

Article

Acidosis induces synovial fibroblasts to release vascular endothelial growth factor via acid-sensitive ion channel 1a

Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells

Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway

Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation

Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells

LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia

PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages

Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin

Real-time lipid patterns to classify viable and necrotic liver tumors

Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants

Supplement

United States & Canadian Academy of Pathology 110th Annual Meeting Abstracts: Never Stop Learning

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Volume 101 Issue 3, March 2021

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