Volume 100 Issue 1, January 2020

Volume 100 Issue 1

Cover: The cover shows identification of nuclei in paraffin sections using the NanoSuit method. Upper row, malignant mesothelioma; middle row, gastric carcinoma (signet ring cell carcinoma); and lower row, breast cancer sample. Left column, hematoxylin and eosin (H&E) staining; middle column, low-vacuum scanning electron microscopy images of samples stained with gold (III) chloride, taken in BSE mode; and right column, mixed low-vacuum scanning electron microscopy images of samples stained with gold (III) chloride. For more information, see the paper by Kawasaki et al, this issue (p 161).

Inside the USCAP Journals

Article

  • Article |

    • Sandra Martinez-Morilla
    • , John McGuire
    • , Patricia Gaule
    • , Lauren Moore
    • , Balazs Acs
    • , Delphine Cougot
    • , Allen M. Gown
    • , Hadi Yaziji
    • , Wei-Lien Wang
    • , Richard W. Cartun
    • , Jason L. Hornick
    • , Lynette M. Sholl
    • , Jingxin Qiu
    • , Mari Mino-Kenudson
    • , Eunhee S. Yi
    • , Mary Beth Beasley
    • , Daniel T. Merrick
    • , Abiy B. Ambaye
    • , Zhong J. Zhang
    • , Jill Walker
    •  & David L. Rimm
  • Article |

    The authors established and characterized a novel gastroesophageal junction (GEJ) cancer cell line derived from the malignant pleural effusion of a treated GEJ cancer patient. This cell line represents a valuable addition to the limited number of bona fide GEJ cancer cell lines for both basic and translational research.

    • Wei Zhang
    • , Taylor A. Williams
    • , Ankur S. Bhagwath
    • , Jared S. Hiermann
    • , Craig D. Peacock
    • , D. Neil Watkins
    • , Peiguo Ding
    • , Jason Y. Park
    • , Elizabeth A. Montgomery
    • , Arlene A. Forastiere
    • , Chunfa Jie
    • , Brandi L. Cantarel
    • , Thai H. Pham
    •  & David H. Wang
  • Article |

    The severe immunodeficiency of NOD.Cg-PrkdcscidIl2rgtm1Wjl (NSG) mice, a widely used strain for generating patient-derived xenografts from primary tumors, impairs drug metabolism and reduces tolerability towards common cytostatic drugs. Consequently, dose finding and tolerance tests are strongly recommended prior to perform large-scale cancer precision medicine approaches.

    • Claudia Maletzki
    • , Stephanie Bock
    • , Philipp Fruh
    • , Karolis Macius
    • , Anika Witt
    • , Friedrich Prall
    •  & Michael Linnebacher

Technical Report