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    This Collection highlights the newest top-viewed content from Laboratory Investigation. Updated each month, we hope you enjoy reading these articles. Laboratory Investigation aims to publish high-quality original research in all biomedical disciplines relating to the understanding of human disease and the application of new methods to the diagnosis of disease.

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    Brightfield microscopy is the preferred method of pathologists for diagnosing solid tumors, utilizing common staining techniques such as hematoxylin and eosin staining and immunohistochemistry.

    Image: Daniel R. Bauer
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    Biology has evolved greatly in the past decade as high-throughput technologies were developed and applied to various biological disciplines. These technologies have generated an unprecedented amount and new types of biological data and how to make sense of “big data” is an emerging technological and conceptual challenge. Computational biology largely relies on computational and statistical algorithms to better understand biological processes. The editors of LI commissioned experts in the fields of computational biology and pathology to compile a special issue on computational pathology. We include original research, technical reports and review articles that use, modify, improve, develop, or summarize computational algorithms to solve biomedical questions.

    Image: Mousumi Roy and Fusheng Wang
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    The editors of Laboratory Investigation present a collection of recent papers that explore the relationships between changes in the mammalian glycome and pathobiology.

    Image: Atsushi Kuno
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    Transient receptor potential (TRP) ion channels serve as cellular sensors that respond to a range of physical and chemical stimuli. Twenty-eight mammalian TRP ion channels have been reported, which belong to six subfamilies (TRPV, TRPM, TRPC, TRPA, TRPP, and TRPML). This collection of articles from Laboratory Investigation describes the roles of various TRP ion channels in inflammation, fibrosis and cancer.

    Image: Koji Shibasaki
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    Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. The pathological spectrum of NAFLD ranges from simple steatosis to the necro-inflammatory and fibro-progressive form, non-alcoholic steatohepatitis (NASH), which may then progress to cirrhosis, liver failure and hepatocellular carcinoma. This web focus features papers from Laboratory Investigation and Modern Pathology that present new models and techniques, diagnostic advances, mechanistic insights and potential innovative therapies for NAFLD and NASH. Photo credit: Ming-Hong Tai

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    The editors of Laboratory Investigation and Modern Pathology present a variety of recent papers related to ocular pathology. These experimental and diagnostic studies cover congenital anomalies, corneal injury and repair, degenerative disease, and various malignancies.

    Image: Peter Lwigale
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    This Laboratory Investigation web focus highlights innovative models and techniques from European contributors. These papers feature advances in molecular genetics, metabolomics, diagnostic imaging, biomarker discovery, and animal models of human disease.

    Image: Helge Taubert
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    The growing burden of neurodegenerative diseases on patients, their families, and health care providers has also stimulated some exciting new developments in the field. This issue of Laboratory Investigation provides a broad view of the field of neurodegenerative diseases with diverse papers focusing on basic research, clinicopathological correlation, neuropathological diagnosis.

    Image: Xinglong Wang