George F Murphy

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Advancing the understanding of human and experimental disease

Latest Research

  • Article
    | Open Access

    Ascorbate can act as an oxidant to induce tumor cell death at a pharmacological dose. Here the authors show that this response is associated with increases in GPCR Gi/o activity. This effect promotes rises in intracellular Ca2+ influx through transient receptor potential channel activity in retinoblastoma cells.

    • Jakub Oronowicz
    • , Jacqueline Reinhard
    • , Peter Sol Reinach
    • , Szymon Ludwiczak
    • , Huan Luo
    • , Marah Hussain Omar Ba Salem
    • , Miriam Monika Kraemer
    • , Heike Biebermann
    • , Vinodh Kakkassery
    •  & Stefan Mergler
  • Article |

    Cardiovascular diseases are the leading cause of death worldwide. Myocardial ischaemia/reperfusion (I/R) injury is a major risk for cardiovascular disease. Herein, the authors demonstrate that circPAN3 ameliorates myocardial I/R injury by absorbing miR-421 to regulate Pink1-mediated autophagy, which may provide potential therapeutic targets in I/R injury.

    • Cheng-Long Zhang
    • , Tian-Yi Long
    • , Si-Si Bi
    • , Sayed-Ali Sheikh
    •  & Fei Li
  • Article
    | Open Access

    This study demonstrates that NFAT5 promotes oral squamous cell carcinoma progression in the hyperosmotic environment through increased expression of DPAGT1, an essential enzyme for protein glycosylation, and altered EGFR subcellular localization from the cytoplasm to the plasma membrane in tumor cells.

    • Shohei Yoshimoto
    • , Hiromitsu Morita
    • , Miho Matsuda
    • , Yoshinori Katakura
    • , Masato Hirata
    •  & Shuichi Hashimoto
  • Technical Report |

    Photoactivatable-Cre (PA-Cre) knock-in mice was established and characterized for the spatial regulation of Cre recombinase activity with blue light exposure. Spot irradiation or long-term irradiation using a wireless LED could induce locus-specific recombination. The PA-Cre knock-in mice promise a useful resource to elucidate gene function in vivo spatiotemporally.

    • Kazuto Yoshimi
    • , Yuko Yamauchi
    • , Takao Tanaka
    • , Toshio Shimada
    • , Moritoshi Sato
    •  & Tomoji Mashimo
  • Article |

    The authors describe a sarcoma with a novel fusion between NUTM1 and MXI1, a member of the MAD gene family. Transcriptome analysis and in vitro studies showed that MXI1-NUTM1 partially phenocopied MYC, providing evidence that MAD family members, normally repressors of MYC activity, can be converted into MYC-like mimics by fusion to NUTM1.

    • Christopher R. McEvoy
    • , Holly Holliday
    • , Niko Thio
    • , Catherine Mitchell
    • , David Y. Choong
    • , Bhargavi Yellapu
    • , Hui San Leong
    • , Huiling Xu
    • , Stephen Lade
    • , Judy Browning
    • , Elena A. Takano
    • , David J. Byrne
    • , Anthony J. Gill
    • , Cuong P. Duong
    • , Jason Li
    • , Andrew P. Fellowes
    • , Stephen B. Fox
    • , Alexander Swarbrick
    •  & Owen W. J. Prall
  • Article |

    This study describes how miR-221-3p in endothelial cells reduces angiogenesis by inhibiting hypoxia-inducible factor-1α. Because antagonism of miR-221-3p significantly improves the cardiac function of mice with heart failure it may be a new and effective molecular target for progressing and treatment of heart failure.

    • Yuying Li
    • , Chenghui Yan
    • , Jiahui Fan
    • , Zhiwei Hou
    •  & Yaling Han

News & Comment


United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

“Security Retina Scanner on Blue Human Eye” Geebshot/iStock

United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

The largest gathering of physician-pathologists in the world