George F Murphy

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Advancing the understanding of human and experimental disease

Latest Research

  • Article |

    The authors investigated the clinicopathologic significance of microRNA-130b expression and analyzed its cancer-specific functions using a cancer cell line. High microRNA-130b expression was associated with adverse clinicopathologic parameters and poor patient outcomes. In vitro, downregulation of microRNA-130b caused a decrease in cell proliferation, migration, and invasion. Hence, miR-130b is a potential therapeutic target for lung cancer.

    • Yeseul Kim
    • , Hyunsung Kim
    • , Seongsik Bang
    • , Seungyun Jee
    •  & Kiseok Jang
  • Article |

    C-X-C chemokine receptor type 5 (CXCR5) regulates retinal pigment epithelium (RPE) homeostasis through PI3K/AKT signaling and by suppression of FOXO1 activation. CXCR5-deficency leads to decreased RPE differentiation, compromised barrier function, and increase in epithelial-mesenchymal transition markers (αSMA, N-cadherin, and vimentin) in CXCR5-deficient RPE cells in vitro and in CXCR5−/− mice.

    • Anton Lennikov
    • , Anthony Mukwaya
    • , Madhu Sudhana Saddala
    •  & Hu Huang
  • Mini Review |

    Tandem mass spectrometry can reveal metabolite positional labeling and improve the performance of metabolic flux analysis as long as daughter ions are carefully inspected. When calculating the fluxes, the tandem mass isotopomer distributions as well as the mass isotopomer distributions of parent and daughter ions should all be used to constrain the fluxes in order to achieve the best performance.

    • Yujue Wang
    • , Sheng Hui
    • , Fredric E. Wondisford
    •  & Xiaoyang Su
  • Article |

    The authors present an assessment of the utility of “third-generation” nanopore sequencing for the confirmation and characterization of mobile element insertions. and discuss how implementation of long-read nanopore sequencing can offer benefits over existing molecular approaches.

    • Christopher M. Watson
    • , Laura A. Crinnion
    • , Helen Lindsay
    • , Rowena Mitchell
    • , Nick Camm
    • , Rachel Robinson
    • , Caroline Joyce
    • , George A. Tanteles
    • , Domhnall J. O’ Halloran
    • , Sergio D. J. Pena
    • , Ian M. Carr
    •  & David T. Bonthron
  • Article |

    Epithelial-to-mesenchymal transition of epithelium and airway epithelial cell proliferation disorder are key events in idiopathic pulmonary fibrosis (IPF) pathogenesis. In the present study, the miR-184/TP63 axis modulates the TGF-β1-induced fibrotic alterations in epithelial cell lines and bleomycin-induced pulmonary fibrosis in mice, confirming that miR-184/TP63 axis is involved in IPF progression.

    • Jianmin Li
    • , Chanyuan Pan
    • , Chao Tang
    • , Wenwen Tan
    • , Weiwei Zhang
    •  & Jing Guan
  • Mini Review |

    This mini-review summarizes the role of βcysteine 93 in oxidative stability of hemoglobin in human blood. βCys93 has been recognized as an end point for radicals originating from heme during oxidative stress and therefore it may be an important biological marker of oxidative stability of hemoglobin within red blood cells intended for transfusion or in hemoglobinopathies.

    • Abdu I. Alayash

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United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

“Security Retina Scanner on Blue Human Eye” Geebshot/iStock

United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

The largest gathering of physician-pathologists in the world