George F Murphy

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Latest Research

  • Article |

    This study shows that exercise increases adropin levels and inhibits NLRP3 inflammasome activation in mice with diet-induced nonalcoholic steatohepatitis (NASH). Furthermore, adropin suppresses palmitic acid-induced NLRP3 inflammasome activation in hepatocytes and Kupffer cells. These results indicate that exercise may inhibit NLRP3 inflammasome activation via adropin induction, resulting in NASH improvement.

    • Wenqi Yang
    • , Ling Liu
    • , Yuan Wei
    • , Chunlu Fang
    • , Shujing Liu
    • , Fu Zhou
    • , Yaping Li
    • , Ge Zhao
    • , Ziyi Guo
    • , Yuan Luo
    •  & Liangming Li
  • Article |

    Nitric oxide (NO) plays an important role in tumor biology, including the generation and maintenance of cancer stem cells (CSCs) subpopulations. Here the authors show that the inhibition of NO production in estrogen-positive breast cancer not only impact the CSC subpopulation but also enhance the efficacy of hormonal therapy with tamoxifen.

    • Laura M. López-Sánchez
    • , Rafael Mena
    • , Silvia Guil-Luna
    • , Ana Mantrana
    • , Jon Peñarando
    • , Marta Toledano-Fonseca
    • , Francisco Conde
    • , Juan R. De la Haba-Rodríguez
    • , Enrique Aranda
    •  & Antonio Rodríguez-Ariza
  • Article |

    Abnormal expression of myocardial infarction-related transcription factor 2 (Mirt2) is associated with myocardial infarction, cardiomyocyte apoptosis and oxidative stress in rats with acute myocardial infarction (AMI). These effects involve the miR-764/PDK1/AKT axis. Therefore, the current findings provide a theoretical basis for the diagnosis and treatment of clinical myocardial infarction by monitoring changes in Mirt2 levels.

    • Fen Zhu
    • , Qing Li
    • , Jun Li
    • , Benlei Li
    •  & Dongsheng Li
  • Article
    | Open Access

    An increase in podocyte apoptosis is positively correlated with the cytoplasmic distribution of YAP in focal segmental glomerulosclerosis (FSGS). YAP inhibition by verteporfin induces nuclear exclusion of YAP, thus increasing the podocyte apoptosis and accelerating disease progression. Therefore, this study suggests that YAP activation and nuclear distribution in podocytes is an endogenous anti-apoptotic mechanism during the progression of FSGS.

    • Qiyuan Zhuang
    • , Fang Li
    • , Jun Liu
    • , Hongyu Wang
    • , Yuchen Tian
    • , Zhigang Zhang
    • , Feng Wang
    • , Zhonghua Zhao
    • , Jianchun Chen
    •  & Huijuan Wu
  • Article
    | Open Access

    Injury-induced transforming growth factor β1 increases sphingosine 1-phosphate (S1P) generation by upregulating in sphingosine kinase 1 activity. The high levels of S1P formation stimulate the S1PR3-linked signaling pathway, which in turn increases vascular endothelial growth factor-A expression levels and angiogenesis in mouse corneas.

    • Shingo Yasuda
    • , Takayoshi Sumioka
    • , Hiroki Iwanishi
    • , Yuka Okada
    • , Masayasu Miyajima
    • , Kana Ichikawa
    • , Peter S. Reinach
    •  & Shizuya Saika
  • Article |

    SECISBP2 overexpression is an independent negative prognostic predictor in diffuse large B-cell lymphoma. Additionally, SECISBP2 positively correlates with selenoprotein expression. In vitro, SECISBP2 knockout increases intracellular reactive oxygen species accumulation via the downregulation of selenoproteins, inhibiting cell growth and promoting cell death after doxorubicin treatment. Therefore, SECISBP2 is a potential therapeutic target for malignant lymphoma.

    • Towako Taguchi
    • , Morito Kurata
    • , Iichiroh Onishi
    • , Yuko Kinowako
    • , Yunosuke Sato
    • , Sayuri Shiono
    • , Sachiko Ishibashi
    • , Masumi Ikeda
    • , Masahide Yamamoto
    • , Masanobu Kitagawa
    •  & Kouhei Yamamoto

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United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

“Security Retina Scanner on Blue Human Eye” Geebshot/iStock

United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

The largest gathering of physician-pathologists in the world