Welcome to Laboratory Investigation

Advancing the understanding of human and experimental disease


  • Visualization of segmented steatosis droplets

    Biology has evolved greatly in the past decade as high-throughput technologies were developed and applied to various biological disciplines. These technologies have generated an unprecedented amount and new types of biological data and how to make sense of “big data” is an emerging technological and conceptual challenge.

  • Immunofluorescent staining of human melanocytic specimens

    This Collection highlights the newest top-viewed content from Laboratory Investigation. Updated each month, we hope you enjoy reading this selection of articles. Laboratory Investigation aims to publish high-quality original research in all biomedical disciplines relating to the understanding of human disease and the application of new methods to the diagnosis of disease.

  • Pseudo-color rendering of fluorescence-like representations of non-small cell lung cancer

    Brightfield microscopy is the preferred method of pathologists for diagnosing solid tumors, utilizing common staining techniques such as hematoxylin and eosin staining and immunohistochemistry. This collection of articles describe new ways to process samples and interpret data generated by histopathology and immunohistochemistry, as well as new technologies that complement these methods.

  • Immunofluorescent staining of a mouse cardiac section with lectins

    The editors of Laboratory Investigation present a collection of recent papers that explore the relationships between changes in the mammalian glycome and pathobiology. These studies describe new roles for glycans in heart disease, neurodegenerative diseases, genetic disorders, and several types of cancer.

Laboratory Investigation is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • Fisetin, a natural flavanol, can localize to the nucleolus and decrease rRNA biogenesis. It preferentially targets tumorigenic cells and cells with cancer stem-like properties. In combination with the RNA Pol I inhibitor BMH-21, it synergistically inhibits pulmonary metastasis, making this combination an exciting potential therapeutic strategy.

    • Sarah C. Kammerud
    • Brandon J. Metge
    • Rajeev S. Samant
    Article Open Access
  • The authors sought to determine whether the infectivity of sporadic Creutzfeldt–Jakob disease prion strains through peripheral routes is different from that from intracranial infection. They found that among the strains, V2 is the most infectious through peripheral routes. Thus, preventive measures against transmission of this strain will be important for the eradication of iatrogenic transmission of Creutzfeldt–Jakob disease.

    • Atsushi Kobayashi
    • Yoshiko Munesue
    • Tetsuyuki Kitamoto
  • This study characterizes the composition of the retinal ganglion cell (RGC) layer and the distribution of RGCs in the cone-dominant ground squirrel retina. The RGC density and the anatomical features of axon-astrocyte interaction in the ground squirrel resemble primates, rendering it an excellent alternative model for RGC neurodegeneration and neuroprotection.

    • Xuan Xiao
    • Tantai Zhao
    • Francisco M. Nadal-Nicolás
    Technical Report
  • Active learning (AL) model is a framework designed for single-cell RNA sequence (scRNA-seq) clustering. This model requires that the researchers label a small number of cells selected by a sample selection algorithm. The labeled cells are then used for the supervision of the clustering, to significantly boost the clustering performance of scRNA-seq.

    • Xiang Lin
    • Haoran Liu
    • Nan Gao
  • Sepsis-induced acute lung injury has been clinically defined as acute respiratory distress syndrome (ARDS). In the present study, the authors reveal that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.

    • Xia Lv
    • Xiang-Yan Zhang
    • Jian-Quan Li
  • The authors aimed to provide new insights into the pathogenesis and treatment of cutaneous burns. They show that the plant polyphenol resveratrol contributes to cell proliferation and migration in lipopolysaccharide-stimulated human epidermal keratinocyte cells. Resveratrol promotes wound healing in a mouse skin wound model via regulation of the miR-212/CASP8 axis.

    • Yu Liu
    • Wu Xiong
    • Jian-Da Zhou

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