George F Murphy

Welcome to Laboratory Investigation

Advancing the understanding of human and experimental disease

Latest Research

  • Article |

    Oculopharyngeal muscular dystrophy (OPMD) is a late-onset myopathy caused by the expansion of polyalanine in the PABPN1 gene. Abnormal accumulation of PABPN1 on the inner membrane of mitochondria was detected in mouse and cell models of OPMD. The localization of expanded PABPN1 in mitochondria may be associated with mitochondrial dysfunction.

    • Tsukasa Doki
    • , Satoshi Yamashita
    • , Fan-Yan Wei
    • , Kentaro Hara
    • , Takahiro Yamamoto
    • , Ziwei Zhang
    • , Xiao Zhang
    • , Nozomu Tawara
    • , Hirotake Hino
    • , Eiichiro Uyama
    • , Takashi Kurashige
    • , Hirofumi Maruyama
    • , Kazuhito Tomizawa
    •  & Yukio Ando
  • Article |

    Because scar formation is regulated by genetic and epigenetic influences, the authors tested the hypothesis that abnormalities in DNA hydroxymethylation in hypertrophic scar formation. They found that 5-hydroxymethylcytosine loss in scar fibroblasts is associated with depletion of TET3 (a DNA methylation enzyme) and increased expression of focal adhesion kinase; and that these effects are partially diminished by ascorbic acid.

    • Yukun Liu
    • , Shuyun Xu
    • , Tingjian Zu
    • , Feng Li
    • , Shengbo Sang
    • , Cynthia Liu
    • , Yang An
    • , Bobin Mi
    • , Dennis P. Orgill
    • , George F. Murphy
    •  & Christine G. Lian
  • Review Article |

    Increasing lines of evidence have shown beneficial effects of physical exercise against or delay neurodegeneration. However, the mechanisms of their beneficial effects are confusing because it involves the connection between the brain and muscles. This review summarizes these findings and discusses the differential and common effects of aerobic versus resistance exercises.

    • Yan Liu
    • , Tim Yan
    • , John Man-Tak Chu
    • , Ying Chen
    • , Sophie Dunnett
    • , Yuen-Shan Ho
    • , Gordon Tin-Chun Wong
    •  & Raymond Chuen-Chung Chang
  • Article |

    There are adjacent TCF/LEF and SMAD consensus binding sites in cyclin D2 and Bmp4 promoters. TCF7, LEF1 and activated SMADs enhance while TCF7L2 inhibits cyclin D2 and Bmp4 expression. Wnt activation increases TCF7 and LEF1 to replace TCF7L2 in these promoters for transcriptional activation and thus promotes cardiomyocyte proliferation.

    • Bo Ye
    • , Liwen Li
    • , Haodong Xu
    • , Yiping Chen
    •  & Faqian Li
  • Article |

    • Maxim Signaevsky
    • , Marcel Prastawa
    • , Kurt Farrell
    • , Nabil Tabish
    • , Elena Baldwin
    • , Natalia Han
    • , Megan A. Iida
    • , John Koll
    • , Clare Bryce
    • , Dushyant Purohit
    • , Vahram Haroutunian
    • , Ann C. McKee
    • , Thor D. Stein
    • , Charles L. White III
    • , Jamie Walker
    • , Timothy E. Richardson
    • , Russell Hanson
    • , Michael J. Donovan
    • , Carlos Cordon-Cardo
    • , Jack Zeineh
    • , Gerardo Fernandez
    •  & John F. Crary