George F Murphy

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Advancing the understanding of human and experimental disease

Latest Research

  • Article |

    Abnormal expression of myocardial infarction-related transcription factor 2 (Mirt2) is associated with myocardial infarction, cardiomyocyte apoptosis and oxidative stress in rats with acute myocardial infarction (AMI). These effects involve the miR-764/PDK1/AKT axis. Therefore, the current findings provide a theoretical basis for the diagnosis and treatment of clinical myocardial infarction by monitoring changes in Mirt2 levels.

    • Fen Zhu
    • , Qing Li
    • , Jun Li
    • , Benlei Li
    •  & Dongsheng Li
  • Article
    | Open Access

    An increase in podocyte apoptosis is positively correlated with the cytoplasmic distribution of YAP in focal segmental glomerulosclerosis (FSGS). YAP inhibition by verteporfin induces nuclear exclusion of YAP, thus increasing the podocyte apoptosis and accelerating disease progression. Therefore, this study suggests that YAP activation and nuclear distribution in podocytes is an endogenous anti-apoptotic mechanism during the progression of FSGS.

    • Qiyuan Zhuang
    • , Fang Li
    • , Jun Liu
    • , Hongyu Wang
    • , Yuchen Tian
    • , Zhigang Zhang
    • , Feng Wang
    • , Zhonghua Zhao
    • , Jianchun Chen
    •  & Huijuan Wu
  • Article
    | Open Access

    Injury-induced transforming growth factor β1 increases sphingosine 1-phosphate (S1P) generation by upregulating in sphingosine kinase 1 activity. The high levels of S1P formation stimulate the S1PR3-linked signaling pathway, which in turn increases vascular endothelial growth factor-A expression levels and angiogenesis in mouse corneas.

    • Shingo Yasuda
    • , Takayoshi Sumioka
    • , Hiroki Iwanishi
    • , Yuka Okada
    • , Masayasu Miyajima
    • , Kana Ichikawa
    • , Peter S. Reinach
    •  & Shizuya Saika
  • Article |

    SECISBP2 overexpression is an independent negative prognostic predictor in diffuse large B-cell lymphoma. Additionally, SECISBP2 positively correlates with selenoprotein expression. In vitro, SECISBP2 knockout increases intracellular reactive oxygen species accumulation via the downregulation of selenoproteins, inhibiting cell growth and promoting cell death after doxorubicin treatment. Therefore, SECISBP2 is a potential therapeutic target for malignant lymphoma.

    • Towako Taguchi
    • , Morito Kurata
    • , Iichiroh Onishi
    • , Yuko Kinowako
    • , Yunosuke Sato
    • , Sayuri Shiono
    • , Sachiko Ishibashi
    • , Masumi Ikeda
    • , Masahide Yamamoto
    • , Masanobu Kitagawa
    •  & Kouhei Yamamoto
  • Article |

    The authors show that genomes of female infertility patients harbor mutations within miRNA genes and 3’ UTR miRNA binding sites that are likely to affect maternal transcript clearance. Such disruption may not be compatible with zygotic genome activation and could cause a failure in embryonic development, implantation or cause early miscarriage, resulting in an infertility diagnosis.

    • Katarzyna M. Tyc
    • , Anthony Wong
    • , Richard T. Scott Jr
    • , Xin Tao
    • , Karen Schindler
    •  & Jinchuan Xing
  • Article |

    The authors report the feasibility of generating, expanding, and enumerating viable patient-derived intraductal papillary mucinous neoplasm (IPMN) tumor and normal pancreatic organoids from fresh and cryopreserved resected tissue. Organoids were characterized histologically and genomically and recapitulated the morphological and mutational profiles of resected IPMNs, suggesting promise of organoids for translational efforts.

    • Francisca Beato
    • , Dayana Reverón
    • , Kaleena B. Dezsi
    • , Antonio Ortiz
    • , Joseph O. Johnson
    • , Dung-Tsa Chen
    • , Karla Ali
    • , Sean J. Yoder
    • , Daniel Jeong
    • , Mokenge Malafa
    • , Pamela Hodul
    • , Kun Jiang
    • , Barbara A. Centeno
    • , Mahmoud A. Abdalah
    • , Jodi A. Balasi
    • , Alexandra F. Tassielli
    • , Bhaswati Sarcar
    • , Jamie K. Teer
    • , Gina M. DeNicola
    • , Jennifer B. Permuth
    •  & Jason B. Fleming

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United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

“Security Retina Scanner on Blue Human Eye” Geebshot/iStock

United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

The largest gathering of physician-pathologists in the world