George F Murphy

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Advancing the understanding of human and experimental disease

Latest Research

  • Article |

    SECISBP2 overexpression is an independent negative prognostic predictor in diffuse large B-cell lymphoma. Additionally, SECISBP2 positively correlates with selenoprotein expression. In vitro, SECISBP2 knockout increases intracellular reactive oxygen species accumulation via the downregulation of selenoproteins, inhibiting cell growth and promoting cell death after doxorubicin treatment. Therefore, SECISBP2 is a potential therapeutic target for malignant lymphoma.

    • Towako Taguchi
    • , Morito Kurata
    • , Iichiroh Onishi
    • , Yuko Kinowako
    • , Yunosuke Sato
    • , Sayuri Shiono
    • , Sachiko Ishibashi
    • , Masumi Ikeda
    • , Masahide Yamamoto
    • , Masanobu Kitagawa
    •  & Kouhei Yamamoto
  • Article |

    The authors show that genomes of female infertility patients harbor mutations within miRNA genes and 3’ UTR miRNA binding sites that are likely to affect maternal transcript clearance. Such disruption may not be compatible with zygotic genome activation and could cause a failure in embryonic development, implantation or cause early miscarriage, resulting in an infertility diagnosis.

    • Katarzyna M. Tyc
    • , Anthony Wong
    • , Richard T. Scott Jr
    • , Xin Tao
    • , Karen Schindler
    •  & Jinchuan Xing
  • Article |

    The authors report the feasibility of generating, expanding, and enumerating viable patient-derived intraductal papillary mucinous neoplasm (IPMN) tumor and normal pancreatic organoids from fresh and cryopreserved resected tissue. Organoids were characterized histologically and genomically and recapitulated the morphological and mutational profiles of resected IPMNs, suggesting promise of organoids for translational efforts.

    • Francisca Beato
    • , Dayana Reverón
    • , Kaleena B. Dezsi
    • , Antonio Ortiz
    • , Joseph O. Johnson
    • , Dung-Tsa Chen
    • , Karla Ali
    • , Sean J. Yoder
    • , Daniel Jeong
    • , Mokenge Malafa
    • , Pamela Hodul
    • , Kun Jiang
    • , Barbara A. Centeno
    • , Mahmoud A. Abdalah
    • , Jodi A. Balasi
    • , Alexandra F. Tassielli
    • , Bhaswati Sarcar
    • , Jamie K. Teer
    • , Gina M. DeNicola
    • , Jennifer B. Permuth
    •  & Jason B. Fleming
  • Article |

    In this study, the authors provide evidence that ectopic expression of oncogenic mutant Kras in pancreatic ducts generates early and late (PanIN) and pancreatic ductal adenocarcinoma (PDAC) . They characterized this Ras rheostat model which reveals elevated Kras mutation frequency and loss of PTEN are important drivers of PanIN and invasive ductal derived PDAC.

    • Kanchan Singh
    • , Melissa Pruski
    • , Rachael Bland
    • , Mamoun Younes
    • , Sushovan Guha
    • , Nirav Thosani
    • , Anirban Maitra
    • , Brooks D. Cash
    • , Florencia McAllister
    • , Craig D. Logsdon
    • , Jeffrey T. Chang
    •  & Jennifer M. Bailey-Lundberg
  • Article |

    In this study, effect of Osr1 deficiency in promoting non-alcoholic fatty liver disease progression was examined. The authors demonstrate that Osr1 regulates hepatic inflammation and cell survival through multiple signaling pathways and DNA methylation modification.

    • Yi Zhou
    • , Zhimin Liu
    • , Ernest C. Lynch
    • , Leya He
    • , Henghui Cheng
    • , Lin Liu
    • , Zhen Li
    • , Jiangyuan Li
    • , Lauren Lawless
    • , Ke K. Zhang
    •  & Linglin Xie
  • Article |

    The authors investigated the clinicopathologic significance of microRNA-130b expression and analyzed its cancer-specific functions using a cancer cell line. High microRNA-130b expression was associated with adverse clinicopathologic parameters and poor patient outcomes. In vitro, downregulation of microRNA-130b caused a decrease in cell proliferation, migration, and invasion. Hence, miR-130b is a potential therapeutic target for lung cancer.

    • Yeseul Kim
    • , Hyunsung Kim
    • , Seongsik Bang
    • , Seungyun Jee
    •  & Kiseok Jang

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United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

“Security Retina Scanner on Blue Human Eye” Geebshot/iStock

United States & Canadian Academy of Pathology 109th Annual Meeting Abstracts: Eyes on You

The largest gathering of physician-pathologists in the world