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Volume 53 Issue 9, September 2024

Exon-skipping gene editing in marmoset

Many disease-related genes cause perinatal death in genetically altered homozygous nonhuman primates (NHP). As NHP resources are limited, efficient methods are necessary to create new genetic models. In a new Article, Sasaki et al. show that using Platinum TALEN gene-editing technology in oocytes is an effective method for producing genetically modified heterozygous marmosets by exon skipping.

See Sato et al.

Cover image: Perception7 / iStock / Getty Images Plus and Marina Spence. Cover design: Marina Spence.

Volume 53 Issue 9

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  • The Laboratory Animal Genetic Reporting (LAG-R) framework, developed by a team of international experts, was recently published in Nature Communications. The LAG-R framework proposes a collection of guidelines to improve the reporting of genetic information for animal models. Lab Animal spoke with corresponding authors Lydia Teboul and Guillaume Pavlovic to know more about the motivation for these recommendations, the benefits for researchers and how to accelerate their adoption.

    • Alexandra Le Bras
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  • This Review provides a comprehensive overview of several available animal models of sudden unexpected death in epilepsy (SUDEP), highlighting their pros and cons to elucidate SUDEP causes and mechanisms.

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    • WeiHui Shao
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