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Volume 53 Issue 6, June 2024

Effect of housing temperature on gut motility

A growing body of evidence suggests that housing mice at 22°C induces chronic cold stress in the animals. In a new Article, Han et al. show that mice raised at 22°C display faster gut transit than mice raised at 30°C, due to increased stress signals. These results further highlight the influence of environmental factors on mouse biology, which can affect experimental reproducibility.

See Monack et al.

Cover image: Marina Spence. Cover design: Marina Spence.

Protocol Review

  • Animals used in biomedical research may experience pain or distress as part of the experimental protocol. By implementing humane endpoints, pain or distress can be prevented or alleviated whilst still meeting scientific aims and objectives. We invited experts from Arizona State University (Samantha Sullivan) and Loma Linda University (Obed Rutebuka), along with USDA and OLAW representatives (Louis DiVincenti and Axel Wolff), to respond to a scenario about the importance of defining humane endpoints in research protocols.

    • Lauren Danridge
    • Bill Greer
    • Axel Wolff
    Protocol Review

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Research Highlights

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News & Views

  • Omne vivum ex ovo — Every living thing comes from an egg. However, keeping eggs healthy and competent to form viable embryos is not an easy task for every organism. A recent paper describes an elegant mechanism utilised by mammalian eggs to manage possibly toxic protein aggregates.

    • Helena Fulka
    News & Views
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Review Articles

  • This Review discusses the use of pig models in animal research for cardiovascular diseases, highlighting their advantages over rodent models and suggesting the need for standardized models to enhance clinical translation and target potential treatments.

    • Hao Jia
    • Yuan Chang
    • Jiangping Song
    Review Article
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Articles

  • The study reveals that raising mice at 22 °C boosts gut transit speed by two times compared to 30 °C, primarily due to stress signals from the hypothalamic–pituitary–adrenal axis and an increase of corticotropin-releasing hormone.

    • Alvin Han
    • Courtney Hudson-Paz
    • Denise M. Monack
    Article Open Access
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