Volume 52 Issue 7, July 2023
In This Issue
News & Views
Unlocking the secrets of the brain requires high precision tools to record neuronal activity. Neuroscientists have tools to capture neuronal activity with unprecedented speed, precision and fidelity. Thanks to a ground-breaking redesign of the linker peptide of GCaMP proteins, a domain seldomly considered for optimization, a new sensor bridges the gap between calcium imaging and electrophysiology.
This protocol describes a humanized mouse model created using neonatal thymus and umbilical cord blood hematopoietic stem cells as nonfetal human tissue sources.