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Volume 51 Issue 5, May 2022

New mouse models for male fertility research

Oxidative stress is major factor that can lead to spermatozoal defects and induce infertility. However, the specific antioxidant mechanisms in male germ cells have not yet been fully elucidated. In a new study this month, Huang, Yang, Pang and colleagues identify LanCL1, a protein abundantly expressed in the testis and brain, as a major antioxidant component, reduction of which is related to male sub/infertility. LanCL1-deficient mice display spermatozoal oxidative damage and subfertility, highlighting the role of LanCL1 in testicular homeostasis.

See Huang et al.

COVER IMAGE: Marina Spence. COVER DESIGN: Marina Spence

Volume 51 Issue 5

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Research Highlights

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  • In this article, the authors identify LanCL1 as a major male germ cell-specific antioxidant gene. Using different mouse models, they show that LanCL1 deficiency results in spermatozoal oxidative damage and impaired male fertility, while LanCL1 transgene expression protects mice against high-fat-diet-induced oxidative damage and subfertility.

    • Chao Huang
    • Chengcheng Yang
    • Zhengli Chen
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