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To overcome challenges such as the rift that has opened up between basic and clinical research, the scientific community first needs to understand the root of these issues. In a new article, Walker. et al. queried the opinion of US biomedical researchers on issues of reproducibility, rigor and attrition rates in drug development. While most researchers agree that there are problems in each of these areas, responses point to differences in researchers’ perspectives within the animal research community. Notably, researchers provide diverse explanations for the high attrition rates observed in drug development.
This protocol details the fabrication and application of a 3D-printed device for facilitating lateral tail-vein injection in mice. The tail vein–illuminating ring comprises a light-emitting diode (LED) lamp box on the side; once the tail has been illuminated by the LED, the vein is more clearly visible along the lateral side of the mouse tail.
Survey data from 1,187 US biomedical researchers using vertebrate animals reveal diverse perspectives within the animal research community on issues of reproducibility and rigor, attrition rates in drug development, research oversight, and public engagement.