Volume 50 Issue 8, August 2021
In This Issue
Announcing the return of Protocol Review
The column will soon continue on with two new coordinators at the helm.
Nonhuman primate models for SARS-CoV-2 Research: Managing demand for specific-pathogen-free (SPF) animals
The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.
Constructing and programming a cost-effective murine running wheel with digital revolution counter
Voluntary wheel running is a valuable metabolic intervention and well-established measure of physical activity in preclinical rodent models. Herein, we describe detailed assembly instructions and provide necessary resources for researchers to build their own running wheels from commercial-off-the-shelf parts and an open-source program at approximately a tenth of the cost of commercially-available options.
Rats on the rise
After a genetic revolution in the 80s, mice overtook rats as the laboratory animal of choice for many researchers. But in recent years, the gene editing capabilities that had lagged a little for the larger rodent have been coming up to par with their murine cousins. Is a return to rats on the way?
Phenotyping spontaneous locomotor activity in inbred and outbred mouse strains by using Digital Ventilated Cages
In this article, the authors compared 24-h spontaneous locomotor activity in three different mouse strains (two inbred strains and one outbred strain) over a period of 2 months by using an automated recording home-cage device. Analysis of different metrics revealed strain-specific spontaneous locomotor patterns.