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Volume 48 Issue 2, February 2019

Modeling sepsis in nonhuman primates

Sepsis is a life-threatening condition that is the result of dysregulated host responses to systemic infections. It remains difficult to treat, aside from the administration of early antibiotics and fluids. Nonhuman primates, like the baboon pictured, are important preclinical models of sepsis that can be more translationally relevant than rodents, providing researchers unique opportunities for understanding the condition and advancing potential therapies to the clinic.

See Chen et al.

Image: Mark Holdefehr/500px/Getty. Cover design: Erin Dewalt

Volume 48 Issue 2

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  • Can the computer eliminate the lab animal? As computational methods become more advanced and data more freely available, in silico modeling approaches have growing potential to help reduce the number of animals needed to test chemical toxicity.

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  • A new study systematically assesses cage enrichment and its effect on mouse welfare and experimental variability.

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