Technology Features

  • Technology Feature |

    Whether the animal has a few hundred neurons or a few billion, mapping the ‘brain’ is a complex endeavor for which there are several different tacks one might take. Data collection continues on.

    • Ellen P. Neff
  • Technology Feature |

    Caring for lab animals is always a priority. But some, depending on the research they are being used for, can require extra attention. As the animals in question get bigger, the task of keeping them in contained facilities can just get a bit more challenging.

    • Ellen P. Neff
  • Technology Feature |

    Alzheimer’s disease remains untreatable, despite decades of preclinical research to understand it better and find therapeutic targets. New ways of thinking about a variety animal models are rising to the challenge.

    • Ellen P. Neff
  • Technology Feature |

    There are animals out there with unique phenotypes that could yield insight into human health and disease. Meet three such fishes from waters around the world: Antarctic icefish, Mexican cavefish, and Atlantic killfish.

    • Jim Kling
  • Technology Feature |

    These 3D structures derived from human cells can be an improvement over simple cell lines, but organoids can still lack important physiological cues for development. Finding the right in vivo environment can take things a step further.

    • Michael Eisenstein
  • Technology Feature |

    Researchers can’t sit their laboratory mice or fruit flies down and ask them how they’re feeling or why they’re behaving in a particular way. Instead, humans are left to observe and interpret the various clues their animals provide. Can machines help?

    • Ellen P. Neff
  • Technology Feature |

    As methods to create new mouse models advance, protecting the intellectual property those animals represent is getting more complicated.

    • Arlene Weintraub
  • Technology Feature |

    Genome sequencing technologies are improving, and researchers have their eyes on a lot more animals.

    • Michael Eisenstein
  • Technology Feature |

    Large animal models can be important translational steps between basic research in rodents and clinical care in humans. Ever thought about a pig?

    • Ellen P. Neff
  • Technology Feature |

    Can the computer eliminate the lab animal? As computational methods become more advanced and data more freely available, in silico modeling approaches have growing potential to help reduce the number of animals needed to test chemical toxicity.

    • Jim Kling
  • Technology Feature |

    Octopuses, squids, and cuttlefishes all have potential as lab animals. As models emerge, what goes in to keeping them happy and healthy in the lab?

    • Ellen P. Neff
  • Technology Feature |

    In vivo bioluminescence imaging offers a non-invasive look inside the body. Its future looks bright.

    • Michael Eisenstein
  • Technology Feature |

    Why handle a mouse if your experiment can be done from the comfort of its home cage?

    • Ellen P. Neff
  • Technology Feature |

    Small but dedicated communities are bringing the earliest lineages of the animal kingdom into the lab. Take a look at the ctenophores, the sponges, and the placozoans.

    • Ellen P. Neff
  • Technology Feature |

    A human can’t easily infiltrate another species’ social group to examine and influence what makes the animals tick. But the right robot can open up a clever way in.

    • Alla Katsnelson
  • Technology Feature |

    Adhering to mouse nomenclature guidelines ensures that research is discoverable, replicable, and less wasteful. So why don’t researchers do it?

    • Smriti Mallapaty
  • Technology Feature |

    When existing systems don’t get the job done, a growing community of researchers are customizing—and sharing—their own solutions.

    • Jim Kling
  • Technology Feature |

    Warmer living conditions could make lab mice better models of human disease.

    • Esther Landhuis