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This Review provides a comprehensive overview of currently available animal models of postpartum hemorrhage, comparing their anatomy and physiology and highlighting their advantages and limitations to support therapeutic development for this condition.
Fernandez, Martinez-Romero et al. review concepts, methods, tools and challenges to leverage Big Data in preclinical aging research, with a focus on rodent studies.
In this Review, the authors provide recommendations for the implementation of the 3Rs in all the steps and procedures in the generation of genetically modified rodents; they also discuss future welfare challenges associated with advances in genome modification techniques.
In this Review, the authors identify and compare available pig models in pain research. They also describe the different pain assessment methods used in pigs and compare them with the pain assessment methods used in humans to identify overlaps and possible improvements.
In this review, the authors compare 28 freely available animal-tracking software applications, highlighting the strengths and weaknesses of the applications in the tracking pipeline, from video acquisition to trajectory generation and data analysis.
In this review, the authors describe how the use of touchscreen-equipped apparatus in behavioral sciences can facilitate the implementation of the 3Rs principles in this discipline and offer a new platform to monitor laboratory animal welfare.
This Review discusses the strengths of the zebrafish model for microbiome research, and highlights important insights gleaned from observational and manipulative microbiome studies in zebrafish.
Deep phenotyping can reveal how genetics, environment and stochasticity affect the development, physiology and behavior of an organism. In this Review, Dhaval S. Patel, Nan Xu and Hang Lu outline the technological and analytical developments that have enabled deep-phenotyping studies in Caenorhabditis elegans.
Treatment for bacterial sepsis remains limited beyond the use of antibiotics. Lingye Chen, Karen Welty-Wolf, and Bryan Kraft review nonhuman primate models of sepsis and highlight their advantages and limitations compared to other preclinical models.
In this article, Dr. Nancy Moran and coworkers present the use of honey bees as models for gastrointestinal research. They compare and contrast the honey bee with humans and other insects in order to present a balanced perspective of the model.
