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With the genetics of a laboratory strain but a more diverse microbiome, ‘wildling’ mice could be a novel complement to commonly used specific pathogen-free animals in preclinical studies.
In medical research, treatments are often thought of as moving “from bench to bedside.” A new study identifies a specific treatment in zebrafish and brings it to a patient, highlighting the role of these animal models in personalized medicine.
The mammalian gut microbiota confers colonization resistance against pathogenic bacteria. Specific pathogen-free C57BL/6 mice from different vendors are variably resistant to oral non-typhoidal Salmonella infection. New work shows that differences in endogenous Enterobacteriaceae determine this phenotypic variability.
Using a systems genetics approach, a new study identifies genetic variants and proteins associated with plasma and hepatic lipid abundance and hepatic lipotoxicity.
A potential new method for non-invasively monitoring physiological parameters in small animals takes advantage of radio frequency near-field coherent sensing technology
A unique paradigm to investigate the intersection between memory, pain, and stress reveals new details about the processes that underlie pain memory. In both mice and men, males seem more susceptible.