Research Highlight |
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Research Highlight |
Distinct microenvironments in primary and transplant tumor models determine response to therapy
- Alexandra Le Bras
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Obituary |
Celebrating the legacy of an IACUC giant: Jerald Silverman, DVM, MS. March 23, 1942 – November 14, 2020
- Sreekant Murthy
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Editorial |
A word from the Editors on Protocol Review
The lab animal community lost Dr. Jerald Silverman on November 14, 2020 to COVID-19. Here, we reflect on Jerry and his long-running and well-loved Protocol Review column.
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Article |
Replacement of surgical vasectomy through the use of wild-type sterile hybrids
Preece, Alghadban et al. explore the use of naturally sterile hybrids as an alternative to vasectomized males for the production of pseudopregnant female mice for embryo transfer. Sterile hybrids can contribute to the refinement of the procedure by avoiding a surgical intervention associated with pain and discomfort.
- Chris Preece
- , Samy Alghadban
- , Amine Bouchareb
- , Daniela Moralli
- , Daniel Biggs
- & Benjamin Davies
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In This Issue |
In This Issue
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Protocol Review |
Compliance requires communication and cooperation
- Harry Fyke
- , Mandy L. King
- , Mary Jourdan
- , Miranda Core
- & Kevin Lewellyn
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Research Highlight |
From model to modeled: heat stressed anemones inform what to CRISPR in a coral
- Ellen Neff
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Research Highlight |
Modeling ALS/FTD in mice: Updates on the C9orf72 BAC transgenic mice
- Alexandra Le Bras
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Correspondence |
Of mice and zebrafish: the impact of the experimenter identity on animal behavior
- Murilo S. de Abreu
- & Allan V. Kalueff
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Technology Feature |
CRISPR gets crunchy
New wrinkles on the Nobel prize-winning method are creating new efficiencies, and new research opportunities.
- Jim Kling
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Perspective |
A fish is not a mouse: understanding differences in background genetics is critical for reproducibility
In this Perspective, the authors highlight the importance of understanding the background genetics of the zebrafish, Danio rerio, and suggest ways that the field might better report genetic information and maintain breeding colonies to improve the transparency and reproducibility of zebrafish research.
- Marcus J. Crim
- & Christian Lawrence
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Article |
Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice
Poon, Y-Y et al. re-visit the effects of isoflurane on cardiovascular functions by measuring temporal changes in blood pressure, heart rate, cardiac performance, baroreflex-mediated sympathetic vasomotor tone, cardiac vagal baroreflex, functional connectivity within baroreflex neural circuits, carotid or cerebral blood flow, respiratory rate and blood gas in mice exposed to 1.5% (vol/vol) isoflurane.
- Yan-Yuen Poon
- , Ching-Yi Tsai
- , Ya‐Hui Huang
- , Jacqueline C. C. Wu
- , Samuel H. H. Chan
- & Julie Y. H. Chan
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In This Issue |
In This Issue
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Protocol |
Experimental murine arteriovenous fistula model to study restenosis after transluminal angioplasty
This protocol describes the different steps to establish a murine model of restenosis after angioplasty of a stenotic arteriovenous fistula (AVF), including a detailed description of the partial nephrectomy procedure to induce chronic kidney disease, the AVF procedure for development of de novo stenosis and the angioplasty treatment associated with progression of restenosis.
- Chuanqi Cai
- , Chenglei Zhao
- , Sreenivasulu Kilari
- , Amit Sharma
- , Avishek K. Singh
- , Michael L. Simeon
- , Avanish Misra
- , Yiqing Li
- & Sanjay Misra
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Technology Feature |
Where the wild zebrafish are
Journeying into the field to study a model organism in its natural habitats.
- Ellen P. Neff
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Research Highlight |
A bilateral murine tumor model to predict response to immunotherapy
- Alexandra Le Bras
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Publisher Correction |
Publisher Correction: The quest for an animal model of coral health and disease
- Ellen P. Neff
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Comment |
Know Your Model: Microbiota & phenotypes
Host genetics, housing conditions, and antibiotic treatments impact microbiota diversity and composition, but microbes that inhabit the mouse gut and skin can also influence severity and penetrance of host mutant phenotypes.
- Michelle N. Perry
- , Susan M. Bello
- & Cynthia L. Smith
