Special Feature Review Article in 2021

Naturally occurring small molecule compounds that target histone deacetylases and their potential applications in cancer therapy

• Yuki Maemoto
• Yuki Shimizu
• Akihiro Ito

Domestication of chemicals attacking metazoan embryogenesis: identification of safe natural products modifying developmental signaling pathways in human

• Naoyuki Nishiya
• Honami Yonezawa

Splicing modulators: on the way from nature to clinic

• Tilman Schneider-Poetsch
• Jagat Krishna Chhipi-Shrestha
• Minoru Yoshida

Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy

• Hiroaki Ikeda
• Hideaki Kakeya

Phenotypic screening system using three-dimensional (3D) culture models for natural product screening

• Hikaru Suenaga
• Noritaka Kagaya
• Kazuo Shin-ya

Proteomics-based target identification of natural products affecting cancer metabolism

• Makoto Muroi
• Hiroyuki Osada

Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics

• Hiroyuki Seimiya
• Kazuo Nagasawa
• Kazuo Shin-ya

Androgen receptor antagonists produced by Streptomyces overcome resistance to enzalutamide

• Masaya Imoto
• Takahiro Fujimaki
• Etsu Tashiro

Screening study of cancer-related cellular signals from microbial natural products

• Masami Ishibashi

The therapeutic potential of mitochondrial toxins

• Manabu Kawada
• Masahide Amemiya
• Tomokazu Ohishi

Natural products targeting cancer cell dependency

• Changxiang Shi
• Eun Ju Yang
• Joong Sup Shim