Special Feature Review Article

Naturally occurring small molecule compounds that target histone deacetylases and their potential applications in cancer therapy

• Yuki Maemoto
• Yuki Shimizu
• Akihiro Ito

Domestication of chemicals attacking metazoan embryogenesis: identification of safe natural products modifying developmental signaling pathways in human

• Naoyuki Nishiya
• Honami Yonezawa

Splicing modulators: on the way from nature to clinic

• Tilman Schneider-Poetsch
• Jagat Krishna Chhipi-Shrestha
• Minoru Yoshida

Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy

• Hiroaki Ikeda
• Hideaki Kakeya

Phenotypic screening system using three-dimensional (3D) culture models for natural product screening

• Hikaru Suenaga
• Noritaka Kagaya
• Kazuo Shin-ya

Proteomics-based target identification of natural products affecting cancer metabolism

• Makoto Muroi
• Hiroyuki Osada

Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics

• Hiroyuki Seimiya
• Kazuo Nagasawa
• Kazuo Shin-ya

Androgen receptor antagonists produced by Streptomyces overcome resistance to enzalutamide

• Masaya Imoto
• Takahiro Fujimaki
• Etsu Tashiro

Screening study of cancer-related cellular signals from microbial natural products

• Masami Ishibashi

The therapeutic potential of mitochondrial toxins

• Manabu Kawada
• Masahide Amemiya
• Tomokazu Ohishi

Natural products targeting cancer cell dependency

• Changxiang Shi
• Eun Ju Yang
• Joong Sup Shim

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

• Kevin Becker
• Marc Stadler

Bioactive small secondary metabolites from the mushrooms Lentinula edodes and Flammulina velutipes

• Emi Fukushima-Sakuno

Plant growth regulators from mushrooms

• Jing Wu
• Hirokazu Kawagishi

Discovery of fingolimod based on the chemical modification of a natural product from the fungus, Isaria sinclairii

• Kenji Chiba

Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates

• Erin P. McCauley
• Ivett C. Piña
• Phillip Crews

Role of symbiosis in the discovery of novel antibiotics

• Vedanjali Gogineni
• Xiaoyan Chen
• Mark T. Hamann

Psilocybin: from ancient magic to modern medicine

• David E. Nichols

Liposidomycin, the first reported nucleoside antibiotic inhibitor of peptidoglycan biosynthesis translocase I: The discovery of liposidomycin and related compounds with a perspective on their application to new antibiotics

• Ken-ichi Kimura

Recent advances in the biosynthesis of nucleoside antibiotics

• Taro Shiraishi
• Tomohisa Kuzuyama