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Article |
Circulating LEAP-2 is associated with puberty in girls
- Silvia Barja-Fernández
- , Javier Lugilde
- , Cecilia Castelao
- , Rocío Vázquez-Cobela
- , Luisa M. Seoane
- , Carlos Diéguez
- , Rosaura Leis
- & Sulay Tovar
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Article |
Neck adipose tissue accumulation is associated with higher overall and central adiposity, a higher cardiometabolic risk, and a pro-inflammatory profile in young adults
- Maria Jose Arias-Tellez
- , Francisco M. Acosta
- , Yolanda Garcia-Rivero
- , Jose Miguel Pascual-Gamarra
- , Elisa Merchan-Ramirez
- , Borja Martinez-Tellez
- , Analiza M. Silva
- , Julio Almansa Lopez
- , Jose M. Llamas-Elvira
- & Jonatan R. Ruiz
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Article |
BMP7 overexpression in adipose tissue induces white adipogenesis and improves insulin sensitivity in ob/ob mice
- Estefania Casana
- , Veronica Jimenez
- , Victor Sacristan
- , Sergio Muñoz
- , Claudia Jambrina
- , Jordi Rodó
- , Miquel Garcia
- , Cristina Mallol
- , Xavier León
- , Sylvie Franckhauser
- & Fatima Bosch
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Article
| Open AccessHigher BMI, but not obesity-related genetic polymorphisms, correlates with lower structural connectivity of the reward network in a population-based study
- Frauke Beyer
- , Rui Zhang
- , Markus Scholz
- , Kerstin Wirkner
- , Markus Loeffler
- , Michael Stumvoll
- , Arno Villringer
- & A. Veronica Witte
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Article
| Open AccessUnderstanding maternal mortality in women with obesity and the role of care they receive: a national case-control study
- Monica Saucedo
- , Ana Paula Esteves-Pereira
- , Lucile Pencolé
- , Agnès Rigouzzo
- , Alain Proust
- , Marie-Hélène Bouvier-Colle
- , Dominique Chassard
- , Henri Cohen
- , Michel Dreyfus
- , Jean-Claude Ducloy
- , Irina Guseva-Canu
- , Jean-Pierre Laplace
- , Véronique Le Guern
- , Sylvie Leroux
- , Estelle Morau
- , Claire Rondet
- , Mathias Rossignol
- , Véronique Tessier
- , Éric Verspyck
- , Philippe Weber
- , Laurent Zieleskiewicz
- & Catherine Deneux-Tharaux
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Article |
Maternal and infant prediction of the child BMI trajectories; studies across two generations of Northern Finland birth cohorts
- Rozenn Nedelec
- , Jouko Miettunen
- , Minna Männikkö
- , Marjo-Riitta Järvelin
- & Sylvain Sebert
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Article |
Morbidly obese subjects show increased serum sulfide in proportion to fat mass
- Ferran Comas
- , Jèssica Latorre
- , Francisco Ortega
- , María Arnoriaga Rodríguez
- , Aina Lluch
- , Mònica Sabater
- , Ferran Rius
- , Xavier Ribas
- , Miquel Costas
- , Wifredo Ricart
- , Albert Lecube
- , José Manuel Fernández-Real
- & José María Moreno-Navarrete
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Article |
Trends in the prevalence of overweight, obesity, and abdominal obesity among Chinese adults between 1993 and 2015
- Shujing Ma
- , Bo Xi
- , Liu Yang
- , Jiahong Sun
- , Min Zhao
- & Pascal Bovet
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Article
| Open AccessType 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity
- Céline Osinski
- , Léa Le Gléau
- , Christine Poitou
- , Juan de Toro-Martin
- , Laurent Genser
- , Magali Fradet
- , Hédi Antoine Soula
- , Armelle Leturque
- , Corinne Blugeon
- , Laurent Jourdren
- , Edwige Ludiwyne Hubert
- , Karine Clément
- , Patricia Serradas
- & Agnès Ribeiro
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Article |
Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity
- Yazan Alwarawrah
- , Amanda G. Nichols
- , William D. Green
- , William Eisner
- , Kaitlin Kiernan
- , Jonathan Warren
- , Laura P. Hale
- , Melinda A. Beck
- & Nancie J. MacIver
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Article |
Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity
- Xanthi Maragkoudaki
- , Matthew Naylor
- , Georgia Papacleovoulou
- , Emilie Stolarczyk
- , Douglas Rees
- , Joaquim M. Pombo
- , Shadi Abu-Hayyeh
- , Anja Czajka
- , Jane K. Howard
- , Afshan N. Malik
- , Catherine Williamson
- , Lucilla Poston
- & Paul D. Taylor
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Review Article |
Social vulnerabilities as risk factor of childhood obesity development and their role in prevention programs
- Isabel Iguacel
- , Ángel Gasch-Gallén
- , Alelí M. Ayala-Marín
- , Pilar De Miguel-Etayo
- & Luis A. Moreno
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Review Article |
Review of the validity and feasibility of image-assisted methods for dietary assessment
- Christoph Höchsmann
- & Corby K. Martin
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Article |
Early life overnutrition impairs plasticity of non-neuronal brainstem cells and drives obesity in offspring across development in rats
- Claudia G. Liberini
- , Misgana Ghidewon
- , Tyler Ling
- , Rinzin Lhamo
- , Nina Juntereal
- , Lauren M. Stein
- & Matthew R. Hayes
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Article |
A total weight loss of 25% shows better predictivity in evaluating the efficiency of bariatric surgery
- Yinfang Tu
- , Yunhui Pan
- , Junfeng Han
- , Jiemin Pan
- , Pin Zhang
- , Weiping Jia
- , Yuqian Bao
- & Haoyong Yu
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Article |
Secular trends in sedentary behaviors and associations with weight indicators among Chinese reproductive-age women from 2004 to 2015: findings from the China Health and Nutrition Survey
- Yun Wang
- , Chang Su
- , Yi-fei Ouyang
- , Xiao-fang Jia
- , Bing Zhang
- , Zhi-hong Wang
- & Hui-jun Wang
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Comment |
Circulating levels of soluble Dipeptidylpeptidase-4 are reduced in human subjects hospitalized for severe COVID-19 infections
Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. For several years DPP-4 inhibitors in addition to GLP-1 analogues are of major importance in the clinical management of obesity and type 2 diabetes. DPP-4 is also known as CD26 and represents a membrane bound protease on the surface of several eukaryotic cell types. Of interest, DPP-4, like ACE2, has been shown to serve as a binding partner for corona-like viruses to enter host immune cells. Since metabolic diseases are major risk factors for the present COVID-19 pandemic, we examined circulating soluble DPP-4 serum concentrations in patients suffering from severe COVID-19 infection and in healthy human subjects in a case control design. In this analysis sDPP-4 levels were significantly lower in COVID-19 patients compared to controls (242.70 ± 202.12 ng/mL versus 497.70 ± 188.13 ng/mL, p = 0.02). We also examined sDPP-4 serum concentrations in patients suffering from sepsis not due to corona-like viruses. In these subjects, sDPP-4 levels were not different compared to healthy case controls (p = 0.14), which might suggest the decrease of sDPP-4 to be specific for corona-like virus infections. Currently, most data point towards membrane bound ACE2 in contrast to DPP-4 as the major binding partner for COVID-19 internalization into host immune cells. However, the finding that the circulating soluble form of DPP-4 is reduced in hospitalized patients might suggest a regulatory role for both, ACE and DPP-4, in COVID-19 infections, especially since obesity and type 2 diabetes are major risk factor for a severe course of the disease
- Kristina Schlicht
- , Nathalie Rohmann
- , Corinna Geisler
- , Tim Hollstein
- , Carina Knappe
- , Katharina Hartmann
- , Jeanette Schwarz
- , Florian Tran
- , Domagoj Schunk
- , Ralf Junker
- , Thomas Bahmer
- , Philip Rosenstiel
- , Dominik Schulte
- , Kathrin Türk
- , Andre Franke
- , Stefan Schreiber
- & Matthias Laudes
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Article |
Reward-related eating, self-regulation, and weight change in pregnancy and postpartum: the Pregnancy Eating Attributes Study (PEAS)
- Tonja R. Nansel
- , Leah M. Lipsky
- , Kyle Burger
- , Myles Faith
- , Wanda Nicholson
- , Alison Stuebe
- , Aiyi Liu
- & Anna Maria Siega-Riz
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Article
| Open AccessEvaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants
- Bahram Namjou
- , Ian B. Stanaway
- , Todd Lingren
- , Frank D. Mentch
- , Barbara Benoit
- , Ozan Dikilitas
- , Xinnan Niu
- , Ning Shang
- , Ashley H. Shoemaker
- , David J. Carey
- , Tooraj Mirshahi
- , Rajbir Singh
- , Jordan G. Nestor
- , Hakon Hakonarson
- , Joshua C. Denny
- , David R. Crosslin
- , Gail P. Jarvik
- , Iftikhar J. Kullo
- , Marc S. Williams
- & John B. Harley
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Article |
Metformin effectively restores the HPA axis function in diet-induced obese rats
- Andrew C. Shin
- , Priya Balasubramanian
- , Pavan Suryadevara
- , Justin Zyskowski
- , Thomas H. Herdt
- , Sheba M. J. MohanKumar
- & Puliyur S. MohanKumar
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Article |
Weight change over 9 years and subsequent risk of venous thromboembolism in the ARIC cohort
- Simone A. French
- , Pamela L. Lutsey
- , Wayne Rosamond
- , Richard F. MacLehose
- , Mary Cushman
- & Aaron R. Folsom
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Article |
Modifications of IGF2 and EGFR plasma protein concentrations in NAFLD patients after bariatric surgery
- Pablo J. Giraudi
- , Michela Giuricin
- , Deborah Bonazza
- , Nicolò de Manzini
- , Claudio Tiribelli
- , Silvia Palmisano
- & Natalia Rosso
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Article
| Open AccessThe role of lifestyle and non-modifiable risk factors in the development of metabolic disturbances from childhood to adolescence
- Claudia Börnhorst
- , Paola Russo
- , Toomas Veidebaum
- , Michael Tornaritis
- , Dénes Molnár
- , Lauren Lissner
- , Staffan Mårild
- , Stefaan De Henauw
- , Luis A. Moreno
- , Anna Floegel
- , Wolfgang Ahrens
- & Maike Wolters
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Article |
Association of obesity indices with in-hospital and 1-year mortality following acute coronary syndrome
- Zuhur Balayah
- , Alawi A. Alsheikh-Ali
- , Wafa Rashed
- , Wael Almahmeed
- , Arif Al Mulla
- , Najib Alrawahi
- , Samia Mora
- , Sagar B. Dugani
- & Mohammad Zubaid
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Article
| Open AccessDiscovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity
- Leo Sungwong Choi
- , In Geun Jo
- , Ku Suk Kang
- , Jeong Ho Im
- , Jiyoung Kim
- , Jinyoung Kim
- , Jin Wook Chung
- & Sang-Ku Yoo
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Comment |
Can reduction in infection and mortality rates from coronavirus be explained by an obesity survival paradox? An analysis at the US statewide level
Coronavirus disease 2019 (COVID-19) is a declared global pandemic with multiple risk factors. Based on recent empirical studies, obesity is considered by several researchers as one of the serious risk factors for coronavirus-related complications. Yet, other scholars argue in favor of the existence of an obesity survival paradox. The objective of the current study is to analyze the potential relationships between different corona indicators and obesity on a statewide level. Since the United States is ranked as one of the OECD countries with a high level of overweight and obesity among its citizens—the majority of US states exceed the 30% benchmark of obese population—it is an especially interesting case study to explore this issue. In an attempt to estimate projected probabilities for infection by coronavirus and mortality rates as a function of obesity prevalence, the fractional logit regression is employed. Findings may support the counter-intuitive possibility of an obesity survival paradox. Consequently, ethical guidelines referring to priority in intubation and intensive care treatments should account for these complex relationships between obesity and corona. Both projected rates of infection and mortality drop with elevated prevalence of obesity. The reasons for these findings might be explained by several conditions such as elevated social distancing from more obese persons, increased metabolic reserves, more aggressive treatment, and unidentified factors that should be examined in future research.
- Yuval Arbel
- , Chaim Fialkoff
- , Amichai Kerner
- & Miryam Kerner
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Article |
Lower extremity lymphatic function predicted by body mass index: a lymphoscintigraphic study of obesity and lipedema
- Arin K. Greene
- & Christopher L. Sudduth
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Article |
Associations between markers of mammary adipose tissue dysfunction and breast cancer prognostic factors
- Sofia Laforest
- , Kaoutar Ennour-Idrissi
- , Geneviève Ouellette
- , Marie-Frédérique Gauthier
- , Annick Michaud
- , Francine Durocher
- , André Tchernof
- & Caroline Diorio
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Article |
Obesity is a potential risk factor contributing to clinical manifestations of COVID-19
- Zhenyu Kang
- , Shanshan Luo
- , Yang Gui
- , Haifeng Zhou
- , Zili Zhang
- , Chunxia Tian
- , Qiaoli Zhou
- , Quansheng Wang
- , Yu Hu
- , Heng Fan
- & Desheng Hu
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Article
| Open AccessObesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations
- Cæcilie Trier
- , Mette Hollensted
- , Theresia M. Schnurr
- , Morten Asp Vonsild Lund
- , Tenna Ruest Haarmark Nielsen
- , Gao Rui
- , Ehm Astrid Andersson
- , Mathilde Svendstrup
- , Dorthe Sadowa Bille
- , Anette P. Gjesing
- , Cilius Esmann Fonvig
- , Christine Frithioff-Bøjsøe
- , Marie Balslev-Harder
- , Shi Quan
- , Michael Gamborg
- , Oluf Pedersen
- , Lars Ängquist
- , Jens-Christian Holm
- & Torben Hansen
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Article |
Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study
- Chalana M. Sol
- , Susana Santos
- , Liesbeth Duijts
- , Alexandros G. Asimakopoulos
- , Maria-Pilar Martinez-Moral
- , Kurunthachalam Kannan
- , Elise M. Philips
- , Leonardo Trasande
- & Vincent W. V. Jaddoe
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Article |
Leptin signaling in vagal afferent neurons supports the absorption and storage of nutrients from high-fat diet
- Kuei-Pin Huang
- , Michael L. Goodson
- , Wendie Vang
- , Hui Li
- , Amanda J. Page
- & Helen E. Raybould
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Brief Communication |
Obesity can offset the cardiometabolic benefits of gestational exercise
- María Perales
- , Pedro L. Valenzuela
- , Rubén Barakat
- , Lidia B. Alejo
- , Yaiza Cordero
- , Mireia Peláez
- & Alejandro Lucia
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Article |
A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
- K. J. Arslanian
- , U. T. Fidow
- , T. Atanoa
- , F. Unasa-Apelu
- , T. Naseri
- , A. I. Wetzel
- , A. Pomer
- , R. L. Duckham
- , S. T. McGarvey
- , J. A. Strayer
- , E. E. Kershaw
- , D. E. Weeks
- & N. L. Hawley
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Brief Communication |
The “Fat but Fit” paradox in the academic context: relationship between physical fitness and weight status with adolescents’ academic achievement
- Marcos D. Martinez-Zamora
- , Pedro L. Valenzuela
- , Tania Pinto-Escalona
- & Óscar Martinez-de-Quel
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Correspondence |
Increased mortality of COVID-19 infected diabetes patients: role of furin proteases
- Senthil Kumar Ganesan
- , Purushothaman Venkatratnam
- , Jaideep Mahendra
- & Nalini Devarajan
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Brief Communication |
Baseline TSH levels and short-term weight loss after different procedures of bariatric surgery
- Emanuele Muraca
- , Alice Oltolini
- , Mattia Pizzi
- , Matteo Villa
- , Giuseppina Manzoni
- , Silvia Perra
- , Francesca Zerbini
- , Eleonora Bianconi
- , Rosa Cannistraci
- , Stefano Ciardullo
- , Pietro Pizzi
- , Guido Lattuada
- & Gianluca Perseghin
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Brief Communication |
Combination of ACTN3 R577X and ACE I/D polymorphisms as a tool for prediction of obesity risk in children
- Patrícia Britto Costa
- , Laura C. Aranalde
- , Poliana E. Correia
- , Guilherme R. F. Cardozo
- , Evelise Sampaio da Silva
- , Monica Schiavon da Costa
- , Sandra Costa Valle
- , Renata Torres Abib Bertacco
- , Simone Pieniz
- , Ronaldo Carvalho Araujo
- , Augusto Schneider
- , Ines Schadock
- & Carlos Castilho Barros
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Brief Communication
| Open AccessCirculating cell adhesion molecules in metabolically healthy obesity
- Arij Mulhem
- , Yusef Moulla
- , Nora Klöting
- , Thomas Ebert
- , Anke Tönjes
- , Mathias Fasshauer
- , Arne Dietrich
- , Michael R. Schön
- , Michael Stumvoll
- , Volker Richter
- & Matthias Blüher
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Article |
Association between cesarean delivery types and obesity in preadolescence
- Alexandra R. Sitarik
- , Suzanne L. Havstad
- , Christine C. Johnson
- , Kyra Jones
- , Albert M. Levin
- , Susan V. Lynch
- , Dennis R. Ownby
- , Andrew G. Rundle
- , Jennifer K. Straughen
- , Ganesa Wegienka
- , Kimberley J. Woodcroft
- , Germaine J. M. Yong
- & Andrea E. Cassidy-Bushrow
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Article |
Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes
- Tang Cam Phung Pham
- , Kirstine Nyvold Bojsen-Møller
- , Sten Madsbad
- , Jørgen Frank Pind Wojtaszewski
- , Erik Arne Richter
- & Lykke Sylow
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Brief Communication
| Open AccessQuantifying childhood fat mass: comparison of a novel height-and-weight-based prediction approach with DXA and bioelectrical impedance
- Mohammed T. Hudda
- , Christopher G. Owen
- , Alicja R. Rudnicka
- , Derek G. Cook
- , Peter H. Whincup
- & Claire M. Nightingale
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Article |
Roux-en-Y gastric bypass and gastric sleeve surgery result in long term bone loss
- Malgorzata M. Brzozowska
- , Thach Tran
- , Dana Bliuc
- , John Jorgensen
- , Michael Talbot
- , Douglas Fenton-Lee
- , Weiwen Chen
- , Angel Hong
- , Alex Viardot
- , Chris P. White
- , Tuan V. Nguyen
- , Nicholas Pocock
- , John A. Eisman
- , Paul A. Baldock
- & Jacqueline R. Center
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Article
| Open AccessPeripancreatic adipose tissue protects against high-fat-diet-induced hepatic steatosis and insulin resistance in mice
- Belén Chanclón
- , Yanling Wu
- , Milica Vujičić
- , Marco Bauzá-Thorbrügge
- , Elin Banke
- , Peter Micallef
- , Julia Kanerva
- , Björn Wilder
- , Patrik Rorsman
- & Ingrid Wernstedt Asterholm
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Article |
Influence of genetic variants in FADS2 and ELOVL2 genes on BMI and PUFAs homeostasis in children and adolescents with obesity
- Alice Maguolo
- , Chiara Zusi
- , Alice Giontella
- , Emanuele Miraglia Del Giudice
- , Angela Tagetti
- , Cristiano Fava
- , Anita Morandi
- & Claudio Maffeis
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Review Article |
Edograms: recording the microstructure of meal intake in humans—a window on appetite mechanisms
- France Bellisle
-
Article |
The obesity paradox in the stress echo lab: fat is better for hearts with ischemia or coronary microvascular dysfunction
- Lauro Cortigiani
- , Maciej Haberka
- , Quirino Ciampi
- , Francesco Bovenzi
- , Bruno Villari
- & Eugenio Picano
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Article |
Influence of adenovirus 36 seropositivity on the expression of adipogenic microRNAs in obese subjects
- Víctor Manríquez
- , Alvaro Gutierrez
- , Alexis Morales
- , Roberto Brito
- , Monica Pavez
- , Jorge Sapunar
- , Luis Fonseca
- , Víctor Molina
- , Eugenia Ortiz
- , Maria Ines Barra
- , Camila Reimer
- , Maria Charles
- , Constance Schneider
- & Alvaro Cerda
