Abstract
Skeletal muscle is a post-mitotic tissue that is thought, conventionally to be maintained by repair and regeneration by a population of stem cell-like satellite cells. Recent findings have brought into question the extent to which these satellite cells represent a single homogeneous population and whether they are the only source of myogenic cells in mature muscle. It has been shown that myogenic cells can be derived from the bone marrow or from the supposedly post-mitotic nuclei of muscle fibres. However, neither of these sources has been demonstrated to generate more than a tiny proportion of muscle nuclei. It remains possible nonetheless that such mechanisms might be exploited for therapeutic uses in primary muscle disease.
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References
Ferrari G et al. Muscle regeneration by bone marrow-derived myogenic progenitors Science 1998 279: 1528–1530
Gussoni E et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation Nature 1999 401: 390–394
Blau HM et al. The evolving concept of a stem cell: entity or function Cell 2001 105: 829–841
Seale P et al. The potential of muscle stem cells Dev Cell 2001 1: 333–342
Schultz E . Satellite cell proliferative compartments in growing skeletal muscles Dev Biol 1996 175: 84–94
Zammit P, Beauchamp J . The skeletal muscle satellite cell: stem cell or son of stem cell? Differentiation 2001 68: 193–204
Reznik M . Origin of myoblasts during skeletal muscle regeneration. Electron microscopic observations Lab Invest 1969 20: 353–563
Bateson RD et al. Circulating cell as a source of myoblasts in regenerating injured mammalian skeletal muscle Nature 1967 13: 1035–1036
Jackson KA et al. Hematopoietic potential of stem cells isolated from murine skeletal muscle Proc Natl Acad Sci USA 1999 96: 14482–14486
Odelberg SJ et al. Dedifferentiation of mammalian myotubes induced by msx1 Cell 2000 103: 1099–1109
Wakeford S et al. X-irradiation improves MDX mouse muscle as a model of myofiber loss in DMD Muscle Nerve 1991 14: 42–50
Pagel CN, Partridge TA . Covert persistence of mdx mouse myopathy is revealed by acute and chronic effects of irradiation J Neurol Sci 1999 164: 103–116
Heslop L et al. Evidence for a myogenic stem cell that is exhausted in dystrophic muscle J Cell Sci 2000 113: 2299–2308
Bauchamp JJ et al. Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source J Cell Biol 1998 14: 1113–1121
Beauchamp JR et al. Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells J Cell Biol 2000 11: 1221–1234
Qu Z . Development of approaches to improve cell survival in myoblast transfer therapy J Cell Biol 1998 142: 1257–1267
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Partridge, T. Cells that participate in regeneration of skeletal muscle. Gene Ther 9, 752–753 (2002). https://doi.org/10.1038/sj.gt.3301764
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DOI: https://doi.org/10.1038/sj.gt.3301764
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