Collections

  • Collection |

    One of the most exciting aspects emerging from the field of gene therapy is that it demonstrates how it can be applied to targeting cancer cells. As cancer is rarely a monogenic disease, this demonstrates the extraordinary reach that gene therapy applications have beyond their original use in addressing those orphan diseases many of us have worked on during our careers. The papers in this collection use standard AAV based delivery approaches, apply AI algorithms, and argue the pros and cons of genome engineering towards CAR-T treatments. This collection is a validation that basic science can be used to build on a greater foundation of scientific capital which can be applied to many aspects of human health.

    Image: Iman van den Bout, Heidi Truter, University of Pretoria, South Africa.
  • Collection |

    The Editors of Eye and Gene Therapy have put together this joint collection on gene therapy in the eye, to showcase some of the recent research in this field.

    Image: Yuichiro Chino
  • Collection |

    Spotlight on South America. Research in regenerative medicine is thriving across the world, and América del Sur is no exception. This special issue of Gene Therapy, coordinated by South America Associate Editor Ursula da Silveira Matte and Guest Editor Hugo Peluffo Zavala, is devoted to work submitted by authors located in many South American countries, with topics including cancer, cardiovascular, Parkinson and inherited diseases. The papers report use of multiple gene and cell therapy technologies, spanning viral and non-viral vectors, genome editing, DNA vaccines, chimeric antigen receptor T-cells (CAR-T), induced pluripotent stem cells (iPSC), and adipose-tissue-derived stem cells.

  • Collection |

    See what scientists world-wide have been citing, reading and sharing. In this Web Collection we highlight a selection of articles from 2018 and 2019 which top the list of the journal's most cited, most read and most shared (including press coverage and Twitter). They showcase the breadth of scope and coverage that Gene Therapy consistently delivers to its readers.

  • Collection |

    To celebrate 25 years of Gene Therapy, the Editor-in-Chief has selected 25 of the journal's most innovative papers to highlight the journal's impact in the field over the past 25 years.

  • Collection |

    The Editor-in-Chief of Gene Therapy is delighted to share with you an Editor's Choice selection of key papers that highlight some of the best current research published in the journal. These papers showcase the breadth of scope and coverage that Gene Therapy consistently deliver to its readers, and have been selected because readers of the journal will find them particularly interesting or useful.

  • Collection |

    The 2019 Nobel Prize in Physiology or Medicine was jointly awarded to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability”. Collectively, their research led to an understanding of the elegant mechanism cells use to respond to changes in oxygen levels, a fundamental process that underpins normal physiologic functioning and plays a critical role in several diseases, including cancer. Via a combination of oxygen-dependant targeted destruction of the Hypoxia Inducible Factor and modulation of gene expression, cells are equipped to survive in a fluctuating environment. This pioneering research helped pave the way towards a plethora of medications that target this pathway. In celebration of their success, we have featured some of their articles in this collection, which includes content from Oncogene, British Journal of Cancer, Pediatric Research, Gene Therapy, Cell Death and Disease, and the Journal of Human Hypertension.

    Image: Emw [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)]
  • Collection |

    The American Society of Gene and Cell Therapy Annual Meeting was held between 29th April - 2nd May 2019, and focused on new developments and advancements in the field of gene and cell therapy research over the last year. The Editor-in-Chief of GT, in the spirit of this important event, is pleased to showcase the work of many researchers in this field, which aligns with the critical themes of this exciting congress.

  • Collection |

    See what scientists world-wide have been citing, reading and sharing. In this Web Collection we highlight a selection of articles from 2017 and 2018 which top the list of the journal's most cited, most read and most shared (including press coverage and Twitter). They showcase the breadth of scope and coverage that Gene Therapy consistently delivers to its readers.

  • Special |

    The Spinraza and Advanced Therapies: a stakeholder special issue of Gene Therapy covers a variety of perspectives and includes comments and review papers from SMA research funders, people affected, experts in the advanced therapies field, SMA scientists and clinicians, regulators, ethics and pricing/IP experts, and community stakeholders.