Figure 9 - Effect of recombinant hemoglobin that inactivates nitric oxide on esophageal peristalsis in a human subject.

Control manometry (a) reveals a sequential peristaltic wave and normal LES relaxation in response to a swallow. Following an infusion of hemoglobin (b), deglutition produces simultaneous esophageal contraction and absent LES relaxation, mimicking the manometric profile of achalasia. (Source: Murray et al.³⁹ with permission from American Gastroenterological Association.)