Figure 8 - Effect of N-methyl-D-aspartate (NMDA) open channel blocker memantine hydrochloride on mechanotransduction property of an esophageal vagal afferent fiber innervating the esophagus of rat.

In each panel, the top trace represents firing frequency of the nerve fiber, the middle trace is the nerve action potentials, and the bottom trace is distending pressure (50 mmHg, 30 seconds). Memantine hydrochloride dose-dependently (1–100 mol/kg, i.v.) inhibited responses to esophageal distention.