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    Guest Editor: Professor Abhishek D. Garg, Katholieke Universiteit Leuven, Belgium The immunology of dying or dead cancer cells is crucial in both health and disease. In recent times, considerable effort has been devoted to understanding how the innate and adaptive immune system perceive and decode various major cell death pathways (like apoptosis, necroptosis, ferroptosis or pyroptosis, amongst others) in dynamic settings of pathologies like cancer and infections. However, an integrated view of cancer cell death immunology that can be reliably exploited for highly efficacious cancer immunotherapy or anti-infection strategies remains enigmatic. This is particularly urgent during infection since herein it is not only about cell death of cells at epithelial or mucosal surface targeted by pathogens but also collateral cell death in immune cells. The aim of this Special Issue is to bring together researchers working on cell death immunology across the fields of cancer or infection biology, and foster a comprehensive discussion on genetic or molecular determinants of cell death immunology. We aim to cover following broad topics: - Immunogenic cell death (ICD) in cancer and infection - Cell death at anti-pathogenic barriers during infection, including COVID19. - Cell death of immune cells e.g., virus-induced T cell senescence and depletion - Cell death immunology in immuno-oncology e.g., anticancer vaccines or chemo/radio-immunotherapy - Mechanisms behind immunology of programmed necrotic pathways - Genetic analyses of cell death characteristics or immunology e.g., single-cell RNAseq profiling. Submission is open to everyone, and all submitted manuscripts will be peer-reviewed through the regular journal review process. If you would like to contribute to this Special Issue, please first send a proposal of your contribution to the editorial office gene@us.nature.com.

  • Focus |

    See what scientists world-wide have been citing and sharing. In this Web Focus we highlight a selection of articles from 2018 which top the list of the journal’s most cited and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). They showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

  • Focus |

    In recent decades enormous effort has been made to elucidate the pathogenesis of autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in which genetic, immunological, environmental and hormonal factors act in concert, representing what was termed some years ago the “mosaic of autoimmunity”. The May 2011 Special Issue on Cutting Edge Issues in Immunology and Autoimmunity summarizes our current understanding of this complex mosaic. The accompanying selection of recent articles from across the Springer Nature provide further insight into this topic.