Guest Editor: Professor Abhishek D. Garg, Katholieke Universiteit Leuven, Belgium The immunology of dying or dead cancer cells is crucial in both health and disease. In recent times, considerable effort has been devoted to understanding how the innate and adaptive immune system perceive and decode various major cell death pathways (like apoptosis, necroptosis, ferroptosis or pyroptosis, amongst others) in dynamic settings of pathologies like cancer and infections. However, an integrated view of cancer cell death immunology that can be reliably exploited for highly efficacious cancer immunotherapy or anti-infection strategies remains enigmatic. This is particularly urgent during infection since herein it is not only about cell death of cells at epithelial or mucosal surface targeted by pathogens but also collateral cell death in immune cells. The aim of this Special Issue is to bring together researchers working on cell death immunology across the fields of cancer or infection biology, and foster a comprehensive discussion on genetic or molecular determinants of cell death immunology. We aim to cover following broad topics: - Immunogenic cell death (ICD) in cancer and infection - Cell death at anti-pathogenic barriers during infection, including COVID19. - Cell death of immune cells e.g., virus-induced T cell senescence and depletion - Cell death immunology in immuno-oncology e.g., anticancer vaccines or chemo/radio-immunotherapy - Mechanisms behind immunology of programmed necrotic pathways - Genetic analyses of cell death characteristics or immunology e.g., single-cell RNAseq profiling. Submission is open to everyone, and all submitted manuscripts will be peer-reviewed through the regular journal review process. If you would like to contribute to this Special Issue, please first send a proposal of your contribution to the editorial office gene@us.nature.com.

See what readers worldwide have been citing and sharing. In this Web Focus we highlight a selection of articles from 2021, which top the list of the journal’s most cited, downloaded and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). They showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

During the last century, mankind launched a war against microbes and medicine scored big with the discovery of antimicrobials. These treatments saved and continue saving millions of lives every year. However, at the time we developed these armed forces we did not have the understanding how important the microbiome is to our health, and how these new weapons harm our own lines of defense. With the trillions of microbes that call us home, we form a strong coalition that few enemies dare to fight. However, given successes of modern medicine, we forgot to care for our most intimate friends. Understanding complex microbial ecosystems such as the human gut microbiome requires information about both microbial species and the metabolites they produce. These metabolites are exchanged via a large network of cross-feeding interactions. While technological advances make it possible to gain information about these networks, how the microbial communicome affects host physiology adds yet another layer of complexity. With the renaissance of microbiome work due to technological advances, we started to scratch the tip of the iceberg to unlock some secrets that we can leverage to support health and wellbeing. In this special issue in Genes & Immunity, we have attempted to provide a snapshot of current research activities aiming to gain a better understanding of the co-evolved, bi-directional crosstalk between the microbiome and the host immune system. Mining the microbiome - a treasure trove waiting to be unlocked or to be more pragmatic - from symbiosis to therapy.

See what readers worldwide have been citing and sharing. In this Web Focus we highlight a selection of articles from 2020, which top the list of the journal’s most cited, downloaded and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). They showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

See what readers worldwide have been citing and sharing. In this Web Focus we highlight a selection of articles from 2019, which top the list of the journal’s most cited, downloaded and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). They showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

See what scientists world-wide have been citing and sharing. In this Web Focus we highlight a selection of articles from 2018 which top the list of the journal’s most cited and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). They showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

In recent decades enormous effort has been made to elucidate the pathogenesis of autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in which genetic, immunological, environmental and hormonal factors act in concert, representing what was termed some years ago the “mosaic of autoimmunity”. The May 2011 Special Issue on Cutting Edge Issues in Immunology and Autoimmunity summarizes our current understanding of this complex mosaic. The accompanying selection of recent articles from across the Springer Nature provide further insight into this topic.

The Candidate Genes for Type 1 Diabetes Workshop was held in Washington, DC.

The current issue of Genes and Immunity is devoted to studies on the genetics of systemic lupus erythematosus.